T11L1_HUMAN
ID T11L1_HUMAN Reviewed; 509 AA.
AC Q9NUJ3; D3DR01; Q8IVX4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=T-complex protein 11-like protein 1;
GN Name=TCP11L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-178.
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9NUJ3; Q9UIV1: CNOT7; NbExp=3; IntAct=EBI-2555179, EBI-2105113;
CC Q9NUJ3; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-2555179, EBI-742054;
CC Q9NUJ3; Q5T890: ERCC6L2; NbExp=3; IntAct=EBI-2555179, EBI-3951765;
CC Q9NUJ3; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-2555179, EBI-740641;
CC Q9NUJ3; Q8TEX9: IPO4; NbExp=3; IntAct=EBI-2555179, EBI-395967;
CC Q9NUJ3; P50458: LHX2; NbExp=3; IntAct=EBI-2555179, EBI-12179869;
CC Q9NUJ3; P43365: MAGEA12; NbExp=3; IntAct=EBI-2555179, EBI-749530;
CC Q9NUJ3; P50221: MEOX1; NbExp=3; IntAct=EBI-2555179, EBI-2864512;
CC Q9NUJ3; P26367: PAX6; NbExp=3; IntAct=EBI-2555179, EBI-747278;
CC Q9NUJ3; Q5SXH7-1: PLEKHS1; NbExp=3; IntAct=EBI-2555179, EBI-26412802;
CC Q9NUJ3; Q8TBF2: PRXL2B; NbExp=6; IntAct=EBI-2555179, EBI-7280826;
CC Q9NUJ3; P55036: PSMD4; NbExp=5; IntAct=EBI-2555179, EBI-359318;
CC Q9NUJ3; Q04864-2: REL; NbExp=3; IntAct=EBI-2555179, EBI-10829018;
CC Q9NUJ3; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-2555179, EBI-742426;
CC Q9NUJ3; Q13573: SNW1; NbExp=3; IntAct=EBI-2555179, EBI-632715;
CC Q9NUJ3; O95947: TBX6; NbExp=3; IntAct=EBI-2555179, EBI-2824328;
CC Q9NUJ3; P19474: TRIM21; NbExp=3; IntAct=EBI-2555179, EBI-81290;
CC Q9NUJ3; Q99598: TSNAX; NbExp=3; IntAct=EBI-2555179, EBI-742638;
CC Q9NUJ3; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-2555179, EBI-2799833;
CC Q9NUJ3; Q9GZV5: WWTR1; NbExp=3; IntAct=EBI-2555179, EBI-747743;
CC -!- SIMILARITY: Belongs to the TCP11 family. {ECO:0000305}.
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DR EMBL; AK002198; BAA92131.1; -; mRNA.
DR EMBL; AL121926; CAC48254.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68206.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68207.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68208.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68209.1; -; Genomic_DNA.
DR EMBL; BC041696; AAH41696.1; -; mRNA.
DR CCDS; CCDS7882.1; -.
DR RefSeq; NP_001139013.1; NM_001145541.1.
DR RefSeq; NP_060863.3; NM_018393.3.
DR RefSeq; XP_011518509.1; XM_011520207.2.
DR RefSeq; XP_016873479.1; XM_017017990.1.
DR AlphaFoldDB; Q9NUJ3; -.
DR BioGRID; 120627; 116.
DR IntAct; Q9NUJ3; 37.
DR MINT; Q9NUJ3; -.
DR STRING; 9606.ENSP00000335595; -.
DR iPTMnet; Q9NUJ3; -.
DR PhosphoSitePlus; Q9NUJ3; -.
DR BioMuta; TCP11L1; -.
DR DMDM; 74734348; -.
DR EPD; Q9NUJ3; -.
DR jPOST; Q9NUJ3; -.
DR MassIVE; Q9NUJ3; -.
DR MaxQB; Q9NUJ3; -.
DR PaxDb; Q9NUJ3; -.
DR PeptideAtlas; Q9NUJ3; -.
DR PRIDE; Q9NUJ3; -.
DR ProteomicsDB; 82677; -.
DR Antibodypedia; 1092; 20 antibodies from 10 providers.
DR DNASU; 55346; -.
DR Ensembl; ENST00000334274.9; ENSP00000335595.4; ENSG00000176148.16.
DR Ensembl; ENST00000432887.5; ENSP00000395070.1; ENSG00000176148.16.
DR Ensembl; ENST00000531632.6; ENSP00000433067.1; ENSG00000176148.16.
DR GeneID; 55346; -.
DR KEGG; hsa:55346; -.
DR MANE-Select; ENST00000334274.9; ENSP00000335595.4; NM_018393.4; NP_060863.3.
DR UCSC; uc001mud.3; human.
DR CTD; 55346; -.
DR DisGeNET; 55346; -.
DR GeneCards; TCP11L1; -.
DR HGNC; HGNC:25655; TCP11L1.
DR HPA; ENSG00000176148; Low tissue specificity.
DR neXtProt; NX_Q9NUJ3; -.
DR OpenTargets; ENSG00000176148; -.
DR PharmGKB; PA142670824; -.
DR VEuPathDB; HostDB:ENSG00000176148; -.
DR eggNOG; KOG1981; Eukaryota.
DR GeneTree; ENSGT00940000157402; -.
DR HOGENOM; CLU_026469_0_1_1; -.
DR InParanoid; Q9NUJ3; -.
DR OMA; CRDEDIN; -.
DR OrthoDB; 1230328at2759; -.
DR PhylomeDB; Q9NUJ3; -.
DR TreeFam; TF313385; -.
DR PathwayCommons; Q9NUJ3; -.
DR SignaLink; Q9NUJ3; -.
DR BioGRID-ORCS; 55346; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; TCP11L1; human.
DR GenomeRNAi; 55346; -.
DR Pharos; Q9NUJ3; Tdark.
DR PRO; PR:Q9NUJ3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9NUJ3; protein.
DR Bgee; ENSG00000176148; Expressed in calcaneal tendon and 154 other tissues.
DR ExpressionAtlas; Q9NUJ3; baseline and differential.
DR Genevisible; Q9NUJ3; HS.
DR GO; GO:0005874; C:microtubule; IDA:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR008862; Tcp11.
DR PANTHER; PTHR12832; PTHR12832; 1.
DR Pfam; PF05794; Tcp11; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..509
FT /note="T-complex protein 11-like protein 1"
FT /id="PRO_0000313747"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 109
FT /note="H -> Q (in dbSNP:rs16923785)"
FT /id="VAR_037726"
FT VARIANT 178
FT /note="K -> R (in dbSNP:rs2273549)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037727"
SQ SEQUENCE 509 AA; 57035 MW; 101F53A05F1B3C30 CRC64;
MSENLDKSNV NEAGKSKSND SEEGLEDAVE GADEALQKAI KSDSSSPQRV QRPHSSPPRF
VTVEELLETA RGVTNMALAH EIVVNGDFQI KPVELPENSL KKRVKEIVHK AFWDCLSVQL
SEDPPAYDHA IKLVGEIKET LLSFLLPGHT RLRNQITEVL DLDLIKQEAE NGALDISKLA
EFIIGMMGTL CAPARDEEVK KLKDIKEIVP LFREIFSVLD LMKVDMANFA ISSIRPHLMQ
QSVEYERKKF QEILERQPNS LDFVTQWLEE ASEDLMTQKY KHALPVGGMA AGSGDMPRLS
PVAVQNYAYL KLLKWDHLQR PFPETVLMDQ SRFHELQLQL EQLTILGAVL LVTFSMAAPG
ISSQADFAEK LKMIVKILLT DMHLPSFHLK DVLTTIGEKV CLEVSSCLSL CGSSPFTTDK
ETVLKGQIQA VASPDDPIRR IMESRILTFL ETYLASGHQK PLPTVPGGLS PVQRELEEVA
IKFARLVNYN KMVFCPYYDA ILSKILVRS
