T11L1_MOUSE
ID T11L1_MOUSE Reviewed; 509 AA.
AC Q8BTG3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=T-complex protein 11-like protein 1;
GN Name=Tcp11l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the TCP11 family. {ECO:0000305}.
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DR EMBL; AK082024; BAC38394.1; -; mRNA.
DR EMBL; AL844603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116926; AAI16927.1; -; mRNA.
DR EMBL; BC116932; AAI16933.1; -; mRNA.
DR CCDS; CCDS16491.1; -.
DR RefSeq; NP_796164.1; NM_177190.5.
DR RefSeq; XP_006499797.1; XM_006499734.3.
DR AlphaFoldDB; Q8BTG3; -.
DR STRING; 10090.ENSMUSP00000028597; -.
DR iPTMnet; Q8BTG3; -.
DR PhosphoSitePlus; Q8BTG3; -.
DR MaxQB; Q8BTG3; -.
DR PaxDb; Q8BTG3; -.
DR PeptideAtlas; Q8BTG3; -.
DR PRIDE; Q8BTG3; -.
DR ProteomicsDB; 254513; -.
DR Antibodypedia; 1092; 20 antibodies from 10 providers.
DR DNASU; 320554; -.
DR Ensembl; ENSMUST00000028597; ENSMUSP00000028597; ENSMUSG00000027175.
DR Ensembl; ENSMUST00000111118; ENSMUSP00000106747; ENSMUSG00000027175.
DR GeneID; 320554; -.
DR KEGG; mmu:320554; -.
DR UCSC; uc008lkb.1; mouse.
DR CTD; 55346; -.
DR MGI; MGI:2444263; Tcp11l1.
DR VEuPathDB; HostDB:ENSMUSG00000027175; -.
DR eggNOG; KOG1981; Eukaryota.
DR GeneTree; ENSGT00940000157402; -.
DR HOGENOM; CLU_026469_0_1_1; -.
DR InParanoid; Q8BTG3; -.
DR OMA; CRDEDIN; -.
DR OrthoDB; 1230328at2759; -.
DR PhylomeDB; Q8BTG3; -.
DR TreeFam; TF313385; -.
DR BioGRID-ORCS; 320554; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q8BTG3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BTG3; protein.
DR Bgee; ENSMUSG00000027175; Expressed in heart left ventricle and 68 other tissues.
DR GO; GO:0005874; C:microtubule; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR008862; Tcp11.
DR PANTHER; PTHR12832; PTHR12832; 1.
DR Pfam; PF05794; Tcp11; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..509
FT /note="T-complex protein 11-like protein 1"
FT /id="PRO_0000313748"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NUJ3"
SQ SEQUENCE 509 AA; 56332 MW; E06E0BBE25491905 CRC64;
MSENLDKSHV DEAGEAEAAA SEQGLEGALE CSDETLQKKV KSDSPSSQRV GRPHSSPARL
VTVEELLETA KGVTNMALAH EIVVTGDFRI NAVELAEGSL EKRVKEIVHK AFWDCLSVQL
SEEPPTYDHA IKLVGEIKET LLSFLLPGHT RLRNQITEVL DLELIKQEAE NGALDISKLA
EFIIGMMGIL CAPARDEEVK KLKGIKEIVP LFRAIFSVLD LMKVDMANFA ISSIRPHLMQ
QSVEYERRKF QEVLERQPNS LDFATQWLEE ATNDLLSQKY KHALPAGGGA AGSGDAPLLT
PVSVQNFAYL KLLKWDHFQR PFPETVLMDQ SRFQELQLQL EQLAVLGAVL LVTFSTAAPG
ISGHADFAEK LKMMVKTLLT DMHLPSFHLE DALASIGEKV CLEVSSCLSL CGSSPFSVAK
ETVLKGQIQA LASPEDPIRR IMESRIFTFL ETYLASGHQK PLPTVPGGLG PIQKELEEVA
VKFVRLVNYN KMVFCPYYDA ILSKLLLRS
