T11L2_HUMAN
ID T11L2_HUMAN Reviewed; 519 AA.
AC Q8N4U5; B2RA65; G3V1Y9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=T-complex protein 11-like protein 2;
GN Name=TCP11L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-41.
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N4U5; P46379-2: BAG6; NbExp=3; IntAct=EBI-11897462, EBI-10988864;
CC Q8N4U5; Q9P0U4-2: CXXC1; NbExp=3; IntAct=EBI-11897462, EBI-12743307;
CC Q8N4U5; O14964: HGS; NbExp=3; IntAct=EBI-11897462, EBI-740220;
CC Q8N4U5; O14901: KLF11; NbExp=3; IntAct=EBI-11897462, EBI-948266;
CC Q8N4U5; P68366: TUBA4A; NbExp=4; IntAct=EBI-11897462, EBI-351772;
CC Q8N4U5; Q9NY65: TUBA8; NbExp=3; IntAct=EBI-11897462, EBI-356246;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N4U5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4U5-2; Sequence=VSP_055736, VSP_055737;
CC -!- SIMILARITY: Belongs to the TCP11 family. {ECO:0000305}.
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DR EMBL; AK314055; BAG36762.1; -; mRNA.
DR EMBL; AC079174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC080012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471054; EAW97774.1; -; Genomic_DNA.
DR EMBL; CH471054; EAW97775.1; -; Genomic_DNA.
DR EMBL; BC033617; AAH33617.1; -; mRNA.
DR CCDS; CCDS66456.1; -. [Q8N4U5-2]
DR CCDS; CCDS9104.1; -. [Q8N4U5-1]
DR RefSeq; NP_001273191.1; NM_001286262.1. [Q8N4U5-2]
DR RefSeq; NP_689985.1; NM_152772.2. [Q8N4U5-1]
DR RefSeq; XP_005268824.1; XM_005268767.4. [Q8N4U5-1]
DR RefSeq; XP_005268825.1; XM_005268768.4. [Q8N4U5-1]
DR RefSeq; XP_011536431.1; XM_011538129.2. [Q8N4U5-1]
DR RefSeq; XP_011536432.1; XM_011538130.2. [Q8N4U5-1]
DR RefSeq; XP_016874616.1; XM_017019127.1. [Q8N4U5-1]
DR RefSeq; XP_016874617.1; XM_017019128.1.
DR RefSeq; XP_016874618.1; XM_017019129.1. [Q8N4U5-1]
DR RefSeq; XP_016874619.1; XM_017019130.1. [Q8N4U5-1]
DR RefSeq; XP_016874620.1; XM_017019131.1. [Q8N4U5-1]
DR AlphaFoldDB; Q8N4U5; -.
DR SMR; Q8N4U5; -.
DR BioGRID; 129100; 24.
DR IntAct; Q8N4U5; 14.
DR MINT; Q8N4U5; -.
DR STRING; 9606.ENSP00000299045; -.
DR iPTMnet; Q8N4U5; -.
DR PhosphoSitePlus; Q8N4U5; -.
DR BioMuta; TCP11L2; -.
DR DMDM; 74728903; -.
DR EPD; Q8N4U5; -.
DR jPOST; Q8N4U5; -.
DR MassIVE; Q8N4U5; -.
DR MaxQB; Q8N4U5; -.
DR PaxDb; Q8N4U5; -.
DR PeptideAtlas; Q8N4U5; -.
DR PRIDE; Q8N4U5; -.
DR ProteomicsDB; 32479; -.
DR ProteomicsDB; 71977; -. [Q8N4U5-1]
DR Antibodypedia; 48241; 261 antibodies from 20 providers.
DR DNASU; 255394; -.
DR Ensembl; ENST00000299045.8; ENSP00000299045.3; ENSG00000166046.11. [Q8N4U5-1]
DR Ensembl; ENST00000547153.5; ENSP00000448952.1; ENSG00000166046.11. [Q8N4U5-2]
DR GeneID; 255394; -.
DR KEGG; hsa:255394; -.
DR MANE-Select; ENST00000299045.8; ENSP00000299045.3; NM_152772.3; NP_689985.1.
DR UCSC; uc001tlm.5; human. [Q8N4U5-1]
DR CTD; 255394; -.
DR GeneCards; TCP11L2; -.
DR HGNC; HGNC:28627; TCP11L2.
DR HPA; ENSG00000166046; Tissue enhanced (brain, choroid plexus).
DR neXtProt; NX_Q8N4U5; -.
DR OpenTargets; ENSG00000166046; -.
DR PharmGKB; PA142670825; -.
DR VEuPathDB; HostDB:ENSG00000166046; -.
DR eggNOG; KOG1981; Eukaryota.
DR GeneTree; ENSGT00940000157835; -.
DR HOGENOM; CLU_071976_0_0_1; -.
DR InParanoid; Q8N4U5; -.
DR OMA; YSRQSFT; -.
DR PhylomeDB; Q8N4U5; -.
DR TreeFam; TF313385; -.
DR PathwayCommons; Q8N4U5; -.
DR SignaLink; Q8N4U5; -.
DR BioGRID-ORCS; 255394; 7 hits in 1075 CRISPR screens.
DR ChiTaRS; TCP11L2; human.
DR GenomeRNAi; 255394; -.
DR Pharos; Q8N4U5; Tdark.
DR PRO; PR:Q8N4U5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N4U5; protein.
DR Bgee; ENSG00000166046; Expressed in bone marrow cell and 165 other tissues.
DR ExpressionAtlas; Q8N4U5; baseline and differential.
DR Genevisible; Q8N4U5; HS.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR008862; Tcp11.
DR PANTHER; PTHR12832; PTHR12832; 1.
DR Pfam; PF05794; Tcp11; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..519
FT /note="T-complex protein 11-like protein 2"
FT /id="PRO_0000313750"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q568Z0"
FT VAR_SEQ 258..266
FT /note="SALDQTTEW -> RKAEVAGAS (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055736"
FT VAR_SEQ 267..519
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055737"
FT VARIANT 41
FT /note="A -> T (in dbSNP:rs4964460)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_037728"
FT VARIANT 82
FT /note="A -> S (in dbSNP:rs11837375)"
FT /id="VAR_037729"
FT VARIANT 261
FT /note="D -> N (in dbSNP:rs17218950)"
FT /id="VAR_037730"
FT CONFLICT 137
FT /note="R -> G (in Ref. 1; BAG36762)"
FT /evidence="ECO:0000305"
FT CONFLICT 158
FT /note="V -> A (in Ref. 1; BAG36762)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 519 AA; 58091 MW; DB21CEDFECA17900 CRC64;
MPFNGEKQCV GEDQPSDSDS SRFSESMASL SDYECSRQSF ASDSSSKSSS PASTSPPRVV
TFDEVMATAR NLSNLTLAHE IAVNENFQLK QEALPEKSLA GRVKHIVHQA FWDVLDSELN
ADPPEFEHAI KLFEEIREIL LSFLTPGGNR LRNQICEVLD TDLIRQQAEH SAVDIQGLAN
YVISTMGKLC APVRDNDIRE LKATGNIVEV LRQIFHVLDL MQMDMANFTI MSLRPHLQRQ
LVEYERTKFQ EILEETPSAL DQTTEWIKES VNEELFSLSE SALTPGAENT SKPSLSPTLV
LNNSYLKLLQ WDYQKKELPE TLMTDGARLQ ELTEKLNQLK IIACLSLITN NMVGAITGGL
PELASRLTRI SAVLLEGMNK ETFNLKEVLN SIGIQTCVEV NKTLMERGLP TLNAEIQANL
IGQFSSIEEE DNPIWSLIDK RIKLYMRRLL CLPSPQKCMP PMPGGLAVIQ QELEALGSQY
ANIVNLNKQV YGPFYANILR KLLFNEEAMG KVDASPPTN
