T11L2_MOUSE
ID T11L2_MOUSE Reviewed; 517 AA.
AC Q8K1H7; Q8C2D5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=T-complex protein 11-like protein 2;
GN Name=Tcp11l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Placenta, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the TCP11 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC40581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK088802; BAC40581.1; ALT_INIT; mRNA.
DR EMBL; AK146035; BAE26848.1; -; mRNA.
DR EMBL; BC029663; AAH29663.1; -; mRNA.
DR CCDS; CCDS36016.1; -.
DR RefSeq; NP_666120.1; NM_146008.2.
DR AlphaFoldDB; Q8K1H7; -.
DR SMR; Q8K1H7; -.
DR STRING; 10090.ENSMUSP00000020223; -.
DR iPTMnet; Q8K1H7; -.
DR PhosphoSitePlus; Q8K1H7; -.
DR EPD; Q8K1H7; -.
DR MaxQB; Q8K1H7; -.
DR PaxDb; Q8K1H7; -.
DR PeptideAtlas; Q8K1H7; -.
DR PRIDE; Q8K1H7; -.
DR ProteomicsDB; 263210; -.
DR Antibodypedia; 48241; 261 antibodies from 20 providers.
DR DNASU; 216198; -.
DR Ensembl; ENSMUST00000020223; ENSMUSP00000020223; ENSMUSG00000020034.
DR GeneID; 216198; -.
DR KEGG; mmu:216198; -.
DR UCSC; uc007gks.1; mouse.
DR CTD; 255394; -.
DR MGI; MGI:2444679; Tcp11l2.
DR VEuPathDB; HostDB:ENSMUSG00000020034; -.
DR eggNOG; KOG1981; Eukaryota.
DR GeneTree; ENSGT00940000157835; -.
DR HOGENOM; CLU_026469_0_0_1; -.
DR InParanoid; Q8K1H7; -.
DR OMA; YSRQSFT; -.
DR OrthoDB; 1230328at2759; -.
DR PhylomeDB; Q8K1H7; -.
DR TreeFam; TF313385; -.
DR BioGRID-ORCS; 216198; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Tcp11l2; mouse.
DR PRO; PR:Q8K1H7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8K1H7; protein.
DR Bgee; ENSMUSG00000020034; Expressed in pedal digit and 230 other tissues.
DR Genevisible; Q8K1H7; MM.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR008862; Tcp11.
DR PANTHER; PTHR12832; PTHR12832; 1.
DR Pfam; PF05794; Tcp11; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..517
FT /note="T-complex protein 11-like protein 2"
FT /id="PRO_0000313751"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q568Z0"
SQ SEQUENCE 517 AA; 57889 MW; CDD8BA7B8E209D7B CRC64;
MPFNGEKQCV SEDQQSDSES SRFAEGVASL SDYECSRQSF TSDSSSKSSS PASTSPPRGL
MFDDVMAAAK NLSDMTLAHE IAVNENFQLK QNALPENSLA GQVKRVVHQA FWDVLEADLS
AEPPQYEYAI KLFEEIREIL LSFLTPGGNR LHSQICEVLD IDLIRQQAEH SAVDIQGLAN
YVITTMGKIC APVRDEDIRE LKATTNIVEM LRQIFRVLDL MRMDMMNFVI RNIRPHIQHH
LVEYERNKFQ EVVEETPNAL SQTTEWLKES IDKELLSETD VAPAAEHSST PSLSPLLVLN
NCYLKLLQWD YQKKVLPETL MTDGPRLQEL SEKLNQLKMT ACVALITNNM VGAVTEGLPE
LANRLKRISA VLLEGMNKET FNLKEALHSI GVQTCAEVNK ALEERGSPTL NAEVQANLVG
QLSSLEEKDN PVCTLMDKRI QLYMKGLLCL PSTQKSMPPV PGGLDVIQRE LEVLGCQYAN
IVNLNKQVYG PFYANIFRKL LFRDEAVGKI DASLPTN
