T11X2_HUMAN
ID T11X2_HUMAN Reviewed; 407 AA.
AC Q5H9J9;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=T-complex protein 11 X-linked protein 2;
GN Name=TCP11X2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the TCP11 family. {ECO:0000305}.
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DR EMBL; AL356322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z68332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z70226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z81367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590069; CAI40395.1; -; Genomic_DNA.
DR EMBL; Z70689; CAI41980.1; -; Genomic_DNA.
DR RefSeq; NP_001264352.1; NM_001277423.1.
DR AlphaFoldDB; Q5H9J9; -.
DR BioGRID; 3190525; 3.
DR STRING; 9606.ENSP00000392879; -.
DR PhosphoSitePlus; Q5H9J9; -.
DR BioMuta; TCP11X2; -.
DR DMDM; 74755458; -.
DR PaxDb; Q5H9J9; -.
DR PRIDE; Q5H9J9; -.
DR DNASU; 100996648; -.
DR GeneID; 100996648; -.
DR KEGG; hsa:100996648; -.
DR UCSC; uc004ejd.1; human.
DR CTD; 100996648; -.
DR GeneCards; TCP11X2; -.
DR HGNC; HGNC:48335; TCP11X2.
DR neXtProt; NX_Q5H9J9; -.
DR eggNOG; KOG1981; Eukaryota.
DR HOGENOM; CLU_026469_0_0_1; -.
DR InParanoid; Q5H9J9; -.
DR OrthoDB; 1230328at2759; -.
DR PhylomeDB; Q5H9J9; -.
DR TreeFam; TF313385; -.
DR BioGRID-ORCS; 100996648; 37 hits in 598 CRISPR screens.
DR GenomeRNAi; 100996648; -.
DR Pharos; Q5H9J9; Tdark.
DR PRO; PR:Q5H9J9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5H9J9; protein.
DR GO; GO:0001669; C:acrosomal vesicle; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR GO; GO:0010737; P:protein kinase A signaling; IBA:GO_Central.
DR GO; GO:1902490; P:regulation of sperm capacitation; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR008862; Tcp11.
DR PANTHER; PTHR12832; PTHR12832; 1.
DR Pfam; PF05794; Tcp11; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..407
FT /note="T-complex protein 11 X-linked protein 2"
FT /id="PRO_0000424012"
SQ SEQUENCE 407 AA; 46373 MW; 473888513662FA7B CRC64;
MYNAFWNHLK EQLLSTPPDF TCALELLKDV KENRLRNEIE EALDTDLLKQ EAEHGALDVP
HLSNYILNLM ALLCAPVRDE AIQKLETIRD PVQLLRGILR VLGLMKMDMV NYTIQSFRPY
LQEHSIQYEQ AKFQELLDKQ PSLLDYTTKW LTKAATDITT LCPSSPDSPS SSCSMACSLP
SGAGNNSEPP SPTMVLYQGY LNLLLWDLEN VEFPETLLMD RIRLQELAFQ LHQLTVLASV
LLVARSFSGE VLFRSPEFVD RLKCTTKALT EEFISRPEET MLSVSEQVSQ EVHQGLKDMG
LTTLSSENTA SLLGQLQNIT KKENCIRSIV DQWIRFFLKC CLLHGMQESL LHFPGGLILI
EKELAELGWK FLNLMHHNQQ VFGPYYAEIL KHIIHPAQAQ ETDVEPN
