ID   T120B_BOVIN             Reviewed;         339 AA.
AC   A6QPF8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Transmembrane protein 120B;
GN   Name=TMEM120B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC       channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- SUBUNIT: Heterooligomer with TMEM120A. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC149295; AAI49296.1; -; mRNA.
DR   RefSeq; NP_001095378.1; NM_001101908.2.
DR   AlphaFoldDB; A6QPF8; -.
DR   SMR; A6QPF8; -.
DR   STRING; 9913.ENSBTAP00000012636; -.
DR   PaxDb; A6QPF8; -.
DR   Ensembl; ENSBTAT00000012636; ENSBTAP00000012636; ENSBTAG00000009602.
DR   GeneID; 508790; -.
DR   KEGG; bta:508790; -.
DR   CTD; 144404; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009602; -.
DR   VGNC; VGNC:35957; TMEM120B.
DR   eggNOG; KOG4758; Eukaryota.
DR   GeneTree; ENSGT00390000007848; -.
DR   HOGENOM; CLU_048749_1_1_1; -.
DR   InParanoid; A6QPF8; -.
DR   OMA; YGFQAYN; -.
DR   OrthoDB; 916768at2759; -.
DR   TreeFam; TF313552; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000009602; Expressed in mammary gland and 105 other tissues.
DR   ExpressionAtlas; A6QPF8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0051291; P:protein heterooligomerization; ISS:UniProtKB.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="Transmembrane protein 120B"
FT                   /id="PRO_0000309528"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          1..77
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   339 AA;  40373 MW;  5CBDEE755F272292 CRC64;
     MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELNALQ TSCSSSINKQ KTRLKDLKLT
     LQRYKRHASR EEAELVQQMG ANIKERQNVF FDMEAYLPKK NGLYLNLVLG NVNVTLLSNQ
     AKFAYKDEYE KFKLYLTIIL LLGAVACRFF LHYRVTDEVF NFLLVWYYCT LTIRESILIS
     NGSRIKGWWV SHHYVSTFLS GVMLTWPNGL IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC
     LYRLRALGER NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
     WQVFVLALTF LVLFLGNFLT TLKVVHTKLQ QNRSKAKKP