T120B_DANRE
ID T120B_DANRE Reviewed; 337 AA.
AC Q1LY80; Q503G6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Transmembrane protein 120B;
GN Name=tmem120b; ORFNames=si:dkey-237o15.3, zgc:110614;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH95336.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; BX088560; CAK10778.1; -; Genomic_DNA.
DR EMBL; BC095336; AAH95336.1; ALT_SEQ; mRNA.
DR RefSeq; XP_005169279.1; XM_005169222.2.
DR AlphaFoldDB; Q1LY80; -.
DR SMR; Q1LY80; -.
DR STRING; 7955.ENSDARP00000106726; -.
DR PaxDb; Q1LY80; -.
DR Ensembl; ENSDART00000126248; ENSDARP00000106726; ENSDARG00000042929.
DR Ensembl; ENSDART00000182395; ENSDARP00000148367; ENSDARG00000115087.
DR GeneID; 798580; -.
DR CTD; 144404; -.
DR ZFIN; ZDB-GENE-050522-49; tmem120b.
DR eggNOG; KOG4758; Eukaryota.
DR GeneTree; ENSGT00390000007848; -.
DR InParanoid; Q1LY80; -.
DR OrthoDB; 916768at2759; -.
DR PhylomeDB; Q1LY80; -.
DR TreeFam; TF313552; -.
DR PRO; PR:Q1LY80; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000042929; Expressed in mature ovarian follicle and 21 other tissues.
DR ExpressionAtlas; Q1LY80; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045444; P:fat cell differentiation; IBA:GO_Central.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433; PTHR21433; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="Transmembrane protein 120B"
FT /id="PRO_0000309531"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 1..39
FT /evidence="ECO:0000255"
FT CONFLICT 173
FT /note="E -> A (in Ref. 2; AAH95336)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 40058 MW; 9B03C94AA5DF4666 CRC64;
MSLERCQSEW TEIEQEYQQL QETHKVYRQK LEELTNLQAI CSSAISKQRK GLKDLKQSLY
KCKKSCNGKD SEVINDLQVQ IKERQNVFFD MEAYLPKRNG LYLNLVLGNV NVTLLSNQAK
FAYKDEYEKF KLYMTIILMF GAVTCLFLLN YRVTDEIFNF LLVWYYCTLT IRESILRSNG
SRIKGWWVSH HYVSTFLSGV MLTWPEGPMY QMFRSQFLAF SIYQSCVQFL QYYYQSGCLY
RLRALGERNQ LDLTVEGFQS WMWRGLTFLL PFLFFGHFWQ LYNAVTLFRL SALDDCKEWQ
VFMLALTFLV LFLGNFLTTL KVVHQKLLKN KDKVKNN
