T120B_HUMAN
ID T120B_HUMAN Reviewed; 339 AA.
AC A0PK00; A0PK01; B3KX33;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Transmembrane protein 120B {ECO:0000305};
GN Name=TMEM120B {ECO:0000312|HGNC:HGNC:32008};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC -!- SUBUNIT: Heterooligomer with TMEM120A. {ECO:0000250|UniProtKB:Q3TA38}.
CC -!- INTERACTION:
CC A0PK00; P20292: ALOX5AP; NbExp=3; IntAct=EBI-10171534, EBI-3904621;
CC A0PK00; Q68DC2: ANKS6; NbExp=3; IntAct=EBI-10171534, EBI-7054139;
CC A0PK00; Q6Q788: APOA5; NbExp=3; IntAct=EBI-10171534, EBI-3936819;
CC A0PK00; Q13520: AQP6; NbExp=3; IntAct=EBI-10171534, EBI-13059134;
CC A0PK00; O94778: AQP8; NbExp=3; IntAct=EBI-10171534, EBI-19124986;
CC A0PK00; O60238: BNIP3L; NbExp=3; IntAct=EBI-10171534, EBI-849893;
CC A0PK00; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10171534, EBI-748961;
CC A0PK00; P04233-2: CD74; NbExp=3; IntAct=EBI-10171534, EBI-12222807;
CC A0PK00; P21964: COMT; NbExp=3; IntAct=EBI-10171534, EBI-372265;
CC A0PK00; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10171534, EBI-18013275;
CC A0PK00; Q96BA8: CREB3L1; NbExp=5; IntAct=EBI-10171534, EBI-6942903;
CC A0PK00; Q15125: EBP; NbExp=3; IntAct=EBI-10171534, EBI-3915253;
CC A0PK00; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10171534, EBI-781551;
CC A0PK00; O15552: FFAR2; NbExp=3; IntAct=EBI-10171534, EBI-2833872;
CC A0PK00; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-10171534, EBI-3918971;
CC A0PK00; Q05329: GAD2; NbExp=3; IntAct=EBI-10171534, EBI-9304251;
CC A0PK00; P08034: GJB1; NbExp=3; IntAct=EBI-10171534, EBI-17565645;
CC A0PK00; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-10171534, EBI-3917143;
CC A0PK00; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10171534, EBI-13345167;
CC A0PK00; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-10171534, EBI-13067820;
CC A0PK00; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10171534, EBI-11721746;
CC A0PK00; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-10171534, EBI-1052304;
CC A0PK00; P38484: IFNGR2; NbExp=3; IntAct=EBI-10171534, EBI-3905457;
CC A0PK00; P16871: IL7R; NbExp=3; IntAct=EBI-10171534, EBI-80490;
CC A0PK00; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10171534, EBI-10266796;
CC A0PK00; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-10171534, EBI-465137;
CC A0PK00; P48051: KCNJ6; NbExp=3; IntAct=EBI-10171534, EBI-12017638;
CC A0PK00; O43300: LRRTM2; NbExp=3; IntAct=EBI-10171534, EBI-18096461;
CC A0PK00; O14880: MGST3; NbExp=3; IntAct=EBI-10171534, EBI-724754;
CC A0PK00; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-10171534, EBI-750085;
CC A0PK00; P15941-11: MUC1; NbExp=3; IntAct=EBI-10171534, EBI-17263240;
CC A0PK00; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-10171534, EBI-10247000;
CC A0PK00; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-10171534, EBI-11337973;
CC A0PK00; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10171534, EBI-7545592;
CC A0PK00; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10171534, EBI-10192441;
CC A0PK00; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-10171534, EBI-2466594;
CC A0PK00; Q99942: RNF5; NbExp=3; IntAct=EBI-10171534, EBI-348482;
CC A0PK00; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-10171534, EBI-17247926;
CC A0PK00; Q8IVP1: SH3GL3; NbExp=3; IntAct=EBI-10171534, EBI-6503765;
CC A0PK00; Q14973: SLC10A1; NbExp=3; IntAct=EBI-10171534, EBI-3923031;
CC A0PK00; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10171534, EBI-18159983;
CC A0PK00; Q8NDX2-2: SLC17A8; NbExp=3; IntAct=EBI-10171534, EBI-17249797;
CC A0PK00; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10171534, EBI-17595455;
CC A0PK00; P43003: SLC1A3; NbExp=3; IntAct=EBI-10171534, EBI-359038;
CC A0PK00; P27105: STOM; NbExp=3; IntAct=EBI-10171534, EBI-1211440;
CC A0PK00; P32856-2: STX2; NbExp=3; IntAct=EBI-10171534, EBI-11956649;
CC A0PK00; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-10171534, EBI-12947623;
CC A0PK00; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-10171534, EBI-7238458;
CC A0PK00; Q96AN5: TMEM143; NbExp=3; IntAct=EBI-10171534, EBI-13342951;
CC A0PK00; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10171534, EBI-8638294;
CC A0PK00; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10171534, EBI-11742770;
CC A0PK00; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10171534, EBI-12345267;
CC A0PK00; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10171534, EBI-6447886;
CC A0PK00; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-10171534, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR EMBL; AK126568; BAG54345.1; -; mRNA.
DR EMBL; BC127768; AAI27769.1; -; mRNA.
DR EMBL; BC127769; AAI27770.1; -; mRNA.
DR CCDS; CCDS41852.1; -.
DR RefSeq; NP_001074294.2; NM_001080825.2.
DR RefSeq; XP_016874342.1; XM_017018853.1.
DR PDB; 7F73; EM; 4.00 A; A/B=1-339.
DR PDBsum; 7F73; -.
DR AlphaFoldDB; A0PK00; -.
DR SMR; A0PK00; -.
DR BioGRID; 126849; 109.
DR IntAct; A0PK00; 69.
DR STRING; 9606.ENSP00000404991; -.
DR iPTMnet; A0PK00; -.
DR PhosphoSitePlus; A0PK00; -.
DR SwissPalm; A0PK00; -.
DR BioMuta; TMEM120B; -.
DR EPD; A0PK00; -.
DR jPOST; A0PK00; -.
DR MassIVE; A0PK00; -.
DR MaxQB; A0PK00; -.
DR PaxDb; A0PK00; -.
DR PeptideAtlas; A0PK00; -.
DR PRIDE; A0PK00; -.
DR ProteomicsDB; 76; -.
DR Antibodypedia; 2742; 42 antibodies from 14 providers.
DR DNASU; 144404; -.
DR Ensembl; ENST00000342607.10; ENSP00000345152.6; ENSG00000188735.13.
DR Ensembl; ENST00000449592.7; ENSP00000404991.2; ENSG00000188735.13.
DR GeneID; 144404; -.
DR KEGG; hsa:144404; -.
DR MANE-Select; ENST00000449592.7; ENSP00000404991.2; NM_001080825.2; NP_001074294.2.
DR UCSC; uc001ubc.5; human.
DR CTD; 144404; -.
DR DisGeNET; 144404; -.
DR GeneCards; TMEM120B; -.
DR HGNC; HGNC:32008; TMEM120B.
DR HPA; ENSG00000188735; Low tissue specificity.
DR MIM; 616551; gene.
DR neXtProt; NX_A0PK00; -.
DR OpenTargets; ENSG00000188735; -.
DR PharmGKB; PA162405862; -.
DR VEuPathDB; HostDB:ENSG00000188735; -.
DR eggNOG; KOG4758; Eukaryota.
DR GeneTree; ENSGT00390000007848; -.
DR HOGENOM; CLU_048749_1_1_1; -.
DR InParanoid; A0PK00; -.
DR OMA; YGFQAYN; -.
DR OrthoDB; 916768at2759; -.
DR PhylomeDB; A0PK00; -.
DR TreeFam; TF313552; -.
DR PathwayCommons; A0PK00; -.
DR SignaLink; A0PK00; -.
DR BioGRID-ORCS; 144404; 9 hits in 1081 CRISPR screens.
DR ChiTaRS; TMEM120B; human.
DR GenomeRNAi; 144404; -.
DR Pharos; A0PK00; Tdark.
DR PRO; PR:A0PK00; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A0PK00; protein.
DR Bgee; ENSG00000188735; Expressed in right hemisphere of cerebellum and 133 other tissues.
DR ExpressionAtlas; A0PK00; baseline and differential.
DR Genevisible; A0PK00; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR GO; GO:0051291; P:protein heterooligomerization; ISS:UniProtKB.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433; PTHR21433; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..339
FT /note="Transmembrane protein 120B"
FT /id="PRO_0000309529"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 1..77
FT /evidence="ECO:0000255"
FT CONFLICT 92
FT /note="D -> N (in Ref. 2; AAI27770)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 339 AA; 40246 MW; 15A08B563ED261D3 CRC64;
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ KKHLKDLKLT
LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK NGLYLNLVLG NVNVTLLSNQ
AKFAYKDEYE KFKLYLTIIL LLGAVACRFV LHYRVTDEVF NFLLVWYYCT LTIRESILIS
NGSRIKGWWV SHHYVSTFLS GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC
LYRLRALGER NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
