ID   T120B_XENTR             Reviewed;         335 AA.
AC   Q63ZG0;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Transmembrane protein 120B;
GN   Name=tmem120b;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC       channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC082959; AAH82959.1; -; mRNA.
DR   RefSeq; NP_001011029.1; NM_001011029.2.
DR   AlphaFoldDB; Q63ZG0; -.
DR   SMR; Q63ZG0; -.
DR   STRING; 8364.ENSXETP00000008133; -.
DR   PaxDb; Q63ZG0; -.
DR   DNASU; 496438; -.
DR   Ensembl; ENSXETT00000008133; ENSXETP00000008133; ENSXETG00000003756.
DR   GeneID; 496438; -.
DR   KEGG; xtr:496438; -.
DR   CTD; 144404; -.
DR   Xenbase; XB-GENE-6087368; tmem120b.
DR   eggNOG; KOG4758; Eukaryota.
DR   HOGENOM; CLU_048749_1_1_1; -.
DR   InParanoid; Q63ZG0; -.
DR   OrthoDB; 916768at2759; -.
DR   PhylomeDB; Q63ZG0; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003756; Expressed in egg cell and 18 other tissues.
DR   ExpressionAtlas; Q63ZG0; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; IBA:GO_Central.
DR   GO; GO:0045444; P:fat cell differentiation; IBA:GO_Central.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Transmembrane protein 120B"
FT                   /id="PRO_0000309534"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          1..39
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  39929 MW;  C77C2C2FAB6813A4 CRC64;
     MSLQKCQEEW GELEKEFQQL QETHKVYKQK LEELNGLQNL CSSYINKHKR RLTELKGNLH
     GYKHTSNVEE KELVQQINST IKERHNAFFD MEAYLPKKNG LYLNLVLGNV NVTLLSNQAK
     FAYKDEYEKF KLYLTIILLL GAITCRFVLH YRVTDEVFNF LLVWYYCTLT IRESILISNG
     SRIKGWWVSH HYVSTFLSGV MLTWPDGLMY QIFRNQFLAF SIYQSCVQFL QYYYQSGCLY
     RLRALGERNH LDLTVEGFQS WMWRGLTFLL PFLFFGHFWQ LYNAITLFGL SRHEECKEWQ
     VFVLALTFLL LFLGNFLTTL KVVHTKFQKN KLKKP