T121B_MOUSE
ID T121B_MOUSE Reviewed; 572 AA.
AC Q99MX7;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Transmembrane protein 121B {ECO:0000250|UniProtKB:Q9BXQ6};
DE AltName: Full=Cat eye syndrome critical region protein 6 homolog {ECO:0000250|UniProtKB:Q9BXQ6};
GN Name=Tmem121b {ECO:0000312|MGI:MGI:2136977};
GN Synonyms=Cecr6 {ECO:0000312|MGI:MGI:2136977};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11381032; DOI=10.1101/gr.154901;
RA Footz T.K., Brinkman-Mills P., Banting G.S., Maier S.A., Riazi M.A.,
RA Bridgland L.J., Hu S., Birren B., Minoshima S., Shimizu N., Pan H.,
RA Nguyen T., Fang F., Fu Y., Ray L., Wu H., Shaull S., Phan S., Yao Z.,
RA Chen F., Huan A., Hu P., Wang Q., Loh P., Qi S., Roe B.A., McDermid H.E.;
RT "Analysis of the cat eye syndrome critical region in humans and the region
RT of conserved synteny in mice: a search for candidate genes at or near the
RT human chromosome 22 pericentromere.";
RL Genome Res. 11:1053-1070(2001).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-165 AND SER-548, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the TMEM121 family. {ECO:0000305}.
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DR EMBL; AF277399; AAK17095.1; -; mRNA.
DR CCDS; CCDS57446.1; -.
DR RefSeq; NP_291045.1; NM_033567.1.
DR AlphaFoldDB; Q99MX7; -.
DR SMR; Q99MX7; -.
DR BioGRID; 220425; 1.
DR IntAct; Q99MX7; 2.
DR MINT; Q99MX7; -.
DR STRING; 10090.ENSMUSP00000135924; -.
DR iPTMnet; Q99MX7; -.
DR PhosphoSitePlus; Q99MX7; -.
DR SwissPalm; Q99MX7; -.
DR PaxDb; Q99MX7; -.
DR PRIDE; Q99MX7; -.
DR ProteomicsDB; 254516; -.
DR Antibodypedia; 22642; 118 antibodies from 17 providers.
DR DNASU; 94047; -.
DR Ensembl; ENSMUST00000178687; ENSMUSP00000135924; ENSMUSG00000094626.
DR GeneID; 94047; -.
DR KEGG; mmu:94047; -.
DR UCSC; uc009dnk.1; mouse.
DR CTD; 27439; -.
DR MGI; MGI:2136977; Tmem121b.
DR VEuPathDB; HostDB:ENSMUSG00000094626; -.
DR eggNOG; ENOG502R54H; Eukaryota.
DR GeneTree; ENSGT00940000154822; -.
DR HOGENOM; CLU_539622_0_0_1; -.
DR InParanoid; Q99MX7; -.
DR OMA; GCPDRSG; -.
DR OrthoDB; 1029672at2759; -.
DR PhylomeDB; Q99MX7; -.
DR TreeFam; TF336944; -.
DR BioGRID-ORCS; 94047; 5 hits in 73 CRISPR screens.
DR PRO; PR:Q99MX7; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q99MX7; protein.
DR Bgee; ENSMUSG00000094626; Expressed in visual cortex and 36 other tissues.
DR ExpressionAtlas; Q99MX7; baseline and differential.
DR Genevisible; Q99MX7; MM.
DR InterPro; IPR026624; CECR6.
DR InterPro; IPR032776; CECR6/TMEM121.
DR PANTHER; PTHR47399; PTHR47399; 1.
DR Pfam; PF14997; CECR6_TMEM121; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..572
FT /note="Transmembrane protein 121B"
FT /id="PRO_0000089467"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..547
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 165
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 548
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 572 AA; 58158 MW; 5AC65BBE56503A1C CRC64;
MHPALGHPRA LSSAPASFPP PPAAARLQPL FLRGGSSRGR RGSGDSSTST STSRGGCGGR
RGGGGGSPSS STGAEREDDD ESISISKPLV PAAAALPGPP AQGGVPVSAT APAAASSTST
PTSSCSMTAA DFGAGAAAGT VGGPGSRSAV GAGGTGTGGA ASCCSCCCCC CGRPTRSGRR
GRRRGCSPSP GCRWGYQALS VVLLLAQGGL LDLYLIAVTD LYWCSWIATD LVVVVGWAIF
FAKNSRGRRG GPANSMHNHH QLHHHSAPPL HLSAAASAGA GAKARGGRGG SGGSGAGPGT
TGAAGEFAFA YLAWLIYSIA FTPKVVLILG TSILDLIELR APFGTTGFRL TMALSVPLLY
SLVRAISEAG APPGSAGPLL LQPQQHRAAG CFLGTCLDLL DSFTLVELML DGRVPLPAHL
RYLLIAVYFL TLASPVLWLY ELNTATAAPS WGQTSGPGSC SRLLRLLGGC LVDVPLLALR
SLLVVSYQQP LSIFMLKNLF FLGCRGLEAL EGCWDRGSWV SPSRARSSYG APPSAPPPPP
PPPPQGGSQR GHLENEGGPH GYVNTLAVAS QN
