T1251_CONAA
ID T1251_CONAA Reviewed; 11 AA.
AC P0DUU3;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 1.
DT 23-FEB-2022, entry version 2.
DE RecName: Full=Conotoxin Ama1251 {ECO:0000303|PubMed:31203793};
OS Conus amadis (Amadis cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Leptoconus.
OX NCBI_TaxID=198732;
RN [1]
RP PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=31203793; DOI=10.2174/0929866526666190614144006;
RA Rajesh R.P., Franklin J.B., Badsha I., Arjun P., Jain R.P., Vignesh M.S.,
RA Kannan R.R.;
RT "Proteome based de novo sequencing of novel conotoxins from marine
RT molluscivorous cone snail Conus amadis and neurological activities of its
RT natural venom in zebrafish model.";
RL Protein Pept. Lett. 26:819-833(2019).
CC -!- FUNCTION: Probable toxin that inhibits ion channels. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31203793}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:31203793}.
CC -!- DOMAIN: The cysteine framework is V (CC-CC).
CC -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC 'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC and AC P81755). {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=1251.4; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:31203793};
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Secreted; Toxin.
FT PEPTIDE 1..11
FT /note="Conotoxin Ama1251"
FT /evidence="ECO:0000269|PubMed:31203793"
FT /id="PRO_0000453582"
FT UNSURE 7
FT /note="Q or K"
FT /evidence="ECO:0000305|PubMed:31203793"
SQ SEQUENCE 11 AA; 1255 MW; 976735E5F6DB105E CRC64;
DSCCIEQHCC D