ID   T126A_PONAB             Reviewed;         196 AA.
AC   Q5RAY9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Transmembrane protein 126A;
GN   Name=TMEM126A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM126 family. {ECO:0000305}.
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DR   EMBL; CR858872; CAH91071.1; -; mRNA.
DR   RefSeq; NP_001127371.1; NM_001133899.1.
DR   AlphaFoldDB; Q5RAY9; -.
DR   STRING; 9601.ENSPPYP00000004273; -.
DR   Ensembl; ENSPPYT00000004447; ENSPPYP00000004273; ENSPPYG00000003738.
DR   GeneID; 100174436; -.
DR   KEGG; pon:100174436; -.
DR   CTD; 84233; -.
DR   eggNOG; ENOG502RYF0; Eukaryota.
DR   GeneTree; ENSGT00520000055616; -.
DR   HOGENOM; CLU_105475_1_0_1; -.
DR   InParanoid; Q5RAY9; -.
DR   OMA; KMLFPIM; -.
DR   OrthoDB; 1250876at2759; -.
DR   TreeFam; TF327069; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR009801; TMEM126.
DR   PANTHER; PTHR16296; PTHR16296; 1.
DR   Pfam; PF07114; TMEM126; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..196
FT                   /note="Transmembrane protein 126A"
FT                   /id="PRO_0000271001"
FT   TOPO_DOM        1..34
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        56..57
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..107
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..159
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..196
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   196 AA;  21811 MW;  06EFCC9F4216E0D2 CRC64;
     MENHKSNNTK ENITIVDISR KINQLPEAER NLLEHGSVYV GLNAALCGLI ANSLFRRILN
     VTKARIAAGL PMAWIPFLTT DITYRCFVSF PLNTGDLDCE TCTITRSGLI GLVIGGLYPV
     FLAIPVNGGL AARYQSALLP HKGNILSYWI RTSKPVFRKM LFPIMLQTMF SAYLGSEQYK
     LLIKALQLSE PGKEIH