T126A_RAT
ID T126A_RAT Reviewed; 196 AA.
AC Q5HZA9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Transmembrane protein 126A;
GN Name=Tmem126a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM126 family. {ECO:0000305}.
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DR EMBL; BC089104; AAH89104.1; -; mRNA.
DR RefSeq; NP_001011557.1; NM_001011557.1.
DR RefSeq; XP_006229751.1; XM_006229689.3.
DR AlphaFoldDB; Q5HZA9; -.
DR STRING; 10116.ENSRNOP00000032681; -.
DR PhosphoSitePlus; Q5HZA9; -.
DR jPOST; Q5HZA9; -.
DR PaxDb; Q5HZA9; -.
DR PRIDE; Q5HZA9; -.
DR Ensembl; ENSRNOT00000038333; ENSRNOP00000032681; ENSRNOG00000022748.
DR GeneID; 293113; -.
DR KEGG; rno:293113; -.
DR CTD; 84233; -.
DR RGD; 1305677; Tmem126a.
DR eggNOG; ENOG502RYF0; Eukaryota.
DR GeneTree; ENSGT00520000055616; -.
DR HOGENOM; CLU_105475_1_0_1; -.
DR InParanoid; Q5HZA9; -.
DR OMA; KMLFPIM; -.
DR OrthoDB; 1250876at2759; -.
DR PhylomeDB; Q5HZA9; -.
DR TreeFam; TF327069; -.
DR PRO; PR:Q5HZA9; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000022748; Expressed in heart and 20 other tissues.
DR Genevisible; Q5HZA9; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IBA:GO_Central.
DR GO; GO:0021554; P:optic nerve development; ISO:RGD.
DR InterPro; IPR009801; TMEM126.
DR PANTHER; PTHR16296; PTHR16296; 1.
DR Pfam; PF07114; TMEM126; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..196
FT /note="Transmembrane protein 126A"
FT /id="PRO_0000271002"
FT TOPO_DOM 1..34
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..57
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..106
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..159
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..196
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 21657 MW; C2D8D4114EAB87CC CRC64;
MESHKPSTNK DDLIFNIIPR KIKQLPESDR NLLEYGSAYI GLNAAFGGLI ANSLFRRILN
VTQARVASSL PMAVIPFLTA NLSYHSFVSL PLSTGNLNCE ICTTTRGTLV GFVLGGLYPI
LLAIPVNGGL AARYESSPLP QRGNIFNYWI TISKPVFRKM LFPTLLQTAF AAYLGSRQYK
LLIKALQLPE PDLEIQ
