T126B_HUMAN
ID T126B_HUMAN Reviewed; 230 AA.
AC Q8IUX1; A8K535; A8MSS0; Q32Q09; Q8WVU3; Q96EP3; Q9NZ29;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Complex I assembly factor TMEM126B, mitochondrial {ECO:0000305};
DE AltName: Full=Transmembrane protein 126B;
GN Name=TMEM126B {ECO:0000312|HGNC:HGNC:30883}; ORFNames=HT007;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hypothalamus;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix carcinoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), AND VARIANT
RP VAL-198.
RC TISSUE=B-cell, Blood vessel, and Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=24191001; DOI=10.1073/pnas.1319247110;
RA Andrews B., Carroll J., Ding S., Fearnley I.M., Walker J.E.;
RT "Assembly factors for the membrane arm of human complex I.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:18934-18939(2013).
RN [9]
RP CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION
RP BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [10]
RP IDENTIFICATION IN THE MCIA COMPLEX, AND FUNCTION.
RX PubMed=32320651; DOI=10.1016/j.celrep.2020.107541;
RA Formosa L.E., Muellner-Wong L., Reljic B., Sharpe A.J., Jackson T.D.,
RA Beilharz T.H., Stojanovski D., Lazarou M., Stroud D.A., Ryan M.T.;
RT "Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly
RT Complex Factors in the Biogenesis of Complex I.";
RL Cell Rep. 31:107541-107541(2020).
RN [11]
RP INTERACTION WITH TMEM70.
RX PubMed=33753518; DOI=10.1073/pnas.2100558118;
RA Carroll J., He J., Ding S., Fearnley I.M., Walker J.E.;
RT "TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase
RT and interact with assembly factors for complex I.";
RL Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
RN [12]
RP INVOLVEMENT IN MC1DN29, VARIANTS MC1DN29 70-GLN--GLU-230 DEL AND VAL-212,
RP AND CHARACTERIZATION OF VARIANTS MC1DN29 70-GLN--GLU-230 DEL AND VAL-212.
RX PubMed=27374773; DOI=10.1016/j.ajhg.2016.05.022;
RA Sanchez-Caballero L., Ruzzenente B., Bianchi L., Assouline Z., Barcia G.,
RA Metodiev M.D., Rio M., Funalot B., van den Brand M.A.,
RA Guerrero-Castillo S., Molenaar J.P., Koolen D., Brandt U., Rodenburg R.J.,
RA Nijtmans L.G., Roetig A.;
RT "Mutations in complex I assembly factor TMEM126B result in muscle weakness
RT and isolated complex I deficiency.";
RL Am. J. Hum. Genet. 99:208-216(2016).
RN [13]
RP INVOLVEMENT IN MC1DN29, VARIANT MC1DN29 VAL-212, AND CHARACTERIZATION OF
RP VARIANT MC1DN29 VAL-212.
RX PubMed=27374774; DOI=10.1016/j.ajhg.2016.05.021;
RA Alston C.L., Compton A.G., Formosa L.E., Strecker V., Olahova M.,
RA Haack T.B., Smet J., Stouffs K., Diakumis P., Ciara E., Cassiman D.,
RA Romain N., Yarham J.W., He L., De Paepe B., Vanlander A.V., Seneca S.,
RA Feichtinger R.G., Ploski R., Rokicki D., Pronicka E., Haller R.G.,
RA Van Hove J.L., Bahlo M., Mayr J.A., Van Coster R., Prokisch H., Wittig I.,
RA Ryan M.T., Thorburn D.R., Taylor R.W.;
RT "Biallelic mutations in TMEM126B cause severe complex I deficiency with a
RT variable clinical phenotype.";
RL Am. J. Hum. Genet. 99:217-227(2016).
CC -!- FUNCTION: As part of the MCIA complex, involved in the assembly of the
CC mitochondrial complex I (PubMed:32320651, PubMed:27374773,
CC PubMed:27374774). Participates in constructing the membrane arm of
CC complex I (PubMed:24191001). {ECO:0000269|PubMed:24191001,
CC ECO:0000269|PubMed:27374773, ECO:0000269|PubMed:27374774,
CC ECO:0000269|PubMed:32320651}.
CC -!- SUBUNIT: Part of the mitochondrial complex I assembly/MCIA complex that
CC comprises at least the core subunits TMEM126B, NDUFAF1, ECSIT and ACAD9
CC and complement subunits such as COA1 and TMEM186 (PubMed:32320651).
CC Associates with the intermediate 370 kDa subcomplex of incompletely
CC assembled complex I (PubMed:24191001). Interacts with TMEM70
CC (PubMed:33753518). {ECO:0000269|PubMed:24191001,
CC ECO:0000269|PubMed:32320651, ECO:0000269|PubMed:33753518}.
CC -!- INTERACTION:
CC Q8IUX1; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-2800657, EBI-748896;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:24191001}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:24191001}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8IUX1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IUX1-2; Sequence=VSP_023871, VSP_023872;
CC Name=3;
CC IsoId=Q8IUX1-3; Sequence=VSP_023870, VSP_023873, VSP_023874;
CC Name=4;
CC IsoId=Q8IUX1-4; Sequence=VSP_023875;
CC Name=5;
CC IsoId=Q8IUX1-5; Sequence=VSP_023870;
CC -!- DISEASE: Mitochondrial complex I deficiency, nuclear type 29 (MC1DN29)
CC [MIM:618250]: A form of mitochondrial complex I deficiency, the most
CC common biochemical signature of mitochondrial disorders, a group of
CC highly heterogeneous conditions characterized by defective oxidative
CC phosphorylation, which collectively affects 1 in 5-10000 live births.
CC Clinical disorders have variable severity, ranging from lethal neonatal
CC disease to adult-onset neurodegenerative disorders. Phenotypes include
CC macrocephaly with progressive leukodystrophy, non-specific
CC encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh
CC syndrome, Leber hereditary optic neuropathy, and some forms of
CC Parkinson disease. MC1DN29 transmission pattern is consistent with
CC autosomal recessive inheritance. {ECO:0000269|PubMed:27374773,
CC ECO:0000269|PubMed:27374774}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the TMEM126 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI07901.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF220193; AAF67658.1; -; mRNA.
DR EMBL; CR612738; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK291150; BAF83839.1; -; mRNA.
DR EMBL; AP000642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW75098.1; -; Genomic_DNA.
DR EMBL; BC012065; AAH12065.1; -; mRNA.
DR EMBL; BC017574; AAH17574.1; -; mRNA.
DR EMBL; BC038933; AAH38933.1; -; mRNA.
DR EMBL; BC107900; AAI07901.1; ALT_FRAME; mRNA.
DR CCDS; CCDS53686.1; -. [Q8IUX1-5]
DR CCDS; CCDS8267.2; -. [Q8IUX1-1]
DR RefSeq; NP_001180467.1; NM_001193538.2. [Q8IUX1-5]
DR RefSeq; NP_001243475.1; NM_001256546.1. [Q8IUX1-5]
DR RefSeq; NP_060950.3; NM_018480.4. [Q8IUX1-1]
DR RefSeq; XP_011543467.1; XM_011545165.2. [Q8IUX1-5]
DR AlphaFoldDB; Q8IUX1; -.
DR BioGRID; 120965; 51.
DR ComplexPortal; CPX-6322; Mitochondrial complex I intermediate assembly (MCIA) complex.
DR IntAct; Q8IUX1; 19.
DR MINT; Q8IUX1; -.
DR STRING; 9606.ENSP00000351737; -.
DR TCDB; 9.B.317.1.1; the complex i integral membrane chaperone, tmem126 (tmem126) family.
DR iPTMnet; Q8IUX1; -.
DR PhosphoSitePlus; Q8IUX1; -.
DR SwissPalm; Q8IUX1; -.
DR BioMuta; TMEM126B; -.
DR DMDM; 134035041; -.
DR EPD; Q8IUX1; -.
DR jPOST; Q8IUX1; -.
DR MassIVE; Q8IUX1; -.
DR MaxQB; Q8IUX1; -.
DR PaxDb; Q8IUX1; -.
DR PeptideAtlas; Q8IUX1; -.
DR PRIDE; Q8IUX1; -.
DR ProteomicsDB; 70618; -. [Q8IUX1-1]
DR ProteomicsDB; 70619; -. [Q8IUX1-2]
DR ProteomicsDB; 70620; -. [Q8IUX1-3]
DR ProteomicsDB; 70621; -. [Q8IUX1-4]
DR ProteomicsDB; 70622; -. [Q8IUX1-5]
DR Antibodypedia; 17580; 56 antibodies from 13 providers.
DR DNASU; 55863; -.
DR Ensembl; ENST00000358867.11; ENSP00000351737.7; ENSG00000171204.13. [Q8IUX1-1]
DR Ensembl; ENST00000393375.5; ENSP00000377039.1; ENSG00000171204.13. [Q8IUX1-5]
DR Ensembl; ENST00000534341.1; ENSP00000433471.1; ENSG00000171204.13. [Q8IUX1-4]
DR GeneID; 55863; -.
DR KEGG; hsa:55863; -.
DR MANE-Select; ENST00000358867.11; ENSP00000351737.7; NM_018480.7; NP_060950.3.
DR UCSC; uc001pao.4; human. [Q8IUX1-1]
DR CTD; 55863; -.
DR DisGeNET; 55863; -.
DR GeneCards; TMEM126B; -.
DR HGNC; HGNC:30883; TMEM126B.
DR HPA; ENSG00000171204; Low tissue specificity.
DR MalaCards; TMEM126B; -.
DR MIM; 615533; gene.
DR MIM; 618250; phenotype.
DR neXtProt; NX_Q8IUX1; -.
DR OpenTargets; ENSG00000171204; -.
DR Orphanet; 2609; Isolated complex I deficiency.
DR PharmGKB; PA143485646; -.
DR VEuPathDB; HostDB:ENSG00000171204; -.
DR eggNOG; ENOG502SQEZ; Eukaryota.
DR GeneTree; ENSGT00520000055616; -.
DR HOGENOM; CLU_105475_0_0_1; -.
DR InParanoid; Q8IUX1; -.
DR OMA; QHYARFE; -.
DR OrthoDB; 1358177at2759; -.
DR PhylomeDB; Q8IUX1; -.
DR TreeFam; TF327069; -.
DR PathwayCommons; Q8IUX1; -.
DR Reactome; R-HSA-6799198; Complex I biogenesis.
DR SignaLink; Q8IUX1; -.
DR BioGRID-ORCS; 55863; 36 hits in 1089 CRISPR screens.
DR ChiTaRS; TMEM126B; human.
DR GeneWiki; TMEM126B; -.
DR GenomeRNAi; 55863; -.
DR Pharos; Q8IUX1; Tbio.
DR PRO; PR:Q8IUX1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8IUX1; protein.
DR Bgee; ENSG00000171204; Expressed in pigmented layer of retina and 201 other tissues.
DR ExpressionAtlas; Q8IUX1; baseline and differential.
DR Genevisible; Q8IUX1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
DR InterPro; IPR009801; TMEM126.
DR PANTHER; PTHR16296; PTHR16296; 1.
DR Pfam; PF07114; TMEM126; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chaperone; Disease variant; Membrane; Mitochondrion;
KW Phosphoprotein; Primary mitochondrial disease; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:25944712"
FT CHAIN 2..230
FT /note="Complex I assembly factor TMEM126B, mitochondrial"
FT /id="PRO_0000280716"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..30
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_023870"
FT VAR_SEQ 1..18
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10931946"
FT /id="VSP_023871"
FT VAR_SEQ 19
FT /note="P -> MWIQVWMT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10931946"
FT /id="VSP_023872"
FT VAR_SEQ 133..140
FT /note="DNISKENC -> GEFKFTNV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023873"
FT VAR_SEQ 141..230
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023874"
FT VAR_SEQ 171..230
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023875"
FT VARIANT 70..230
FT /note="Missing (in MC1DN29; loss of function in complex I
FT assembly)"
FT /evidence="ECO:0000269|PubMed:27374773"
FT /id="VAR_081464"
FT VARIANT 198
FT /note="A -> V (in dbSNP:rs17850847)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031188"
FT VARIANT 212
FT /note="G -> V (in MC1DN29; decreased function in complex I
FT assembly; dbSNP:rs141542003)"
FT /evidence="ECO:0000269|PubMed:27374773,
FT ECO:0000269|PubMed:27374774"
FT /id="VAR_081465"
SQ SEQUENCE 230 AA; 25943 MW; B0EB374211C3CF52 CRC64;
MVVFGYEAGT KPRDSGVVPV GTEEAPKVFK MAASMHGQPS PSLEDAKLRR PMVIEIIEKN
FDYLRKEMTQ NIYQMATFGT TAGFSGIFSN FLFRRCFKVK HDALKTYASL ATLPFLSTVV
TDKLFVIDAL YSDNISKENC VFRSSLIGIV CGVFYPSSLA FTKNGRLATK YHTVPLPPKG
RVLIHWMTLC QTQMKLMAIP LVFQIMFGIL NGLYHYAVFE ETLEKTIHEE
