T12BA_XENLA
ID T12BA_XENLA Reviewed; 335 AA.
AC Q5EAX9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Transmembrane protein 120B-A;
GN Name=tmem120b-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC090205; AAH90205.1; -; mRNA.
DR RefSeq; NP_001089276.1; NM_001095807.1.
DR AlphaFoldDB; Q5EAX9; -.
DR SMR; Q5EAX9; -.
DR DNASU; 734324; -.
DR GeneID; 734324; -.
DR KEGG; xla:734324; -.
DR CTD; 734324; -.
DR Xenbase; XB-GENE-6087423; tmem120b.L.
DR OMA; YGFQAYN; -.
DR OrthoDB; 916768at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 734324; Expressed in muscle tissue and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433; PTHR21433; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..335
FT /note="Transmembrane protein 120B-A"
FT /id="PRO_0000309532"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 1..40
FT /evidence="ECO:0000255"
SQ SEQUENCE 335 AA; 39812 MW; F109CF31E1493D60 CRC64;
MSLQKCQEEW SEIEKEFQQL QETHKVYKQK LEELNSLQNL CSSCINKHKR RLTEFKGNLH
GLKRTSNLEE KELVQQIDGT IKERRNAFFD MEAYLPKKNG LYLNLVLGNV NVTLLSTQAK
FAYKDEYEKF KLYLTIILLL GAITCRFVLN YRVTDEVFNF LLVWYYCTLT IRESILISNG
SRIKGWWVSH HYVSTFLSGV MLTWPDGLMY QIFRNQFLAF SIFQSCVQFL QYYYQSGCLY
RLRALGERNH LDLTVEGFQS WMWRGLTFLL PFLFFGHFWQ LYNAITLFGL SRHDACKEWQ
VFVLALTFLL LFLGNFLTTL KVVHTKFQKN KLKKP