ID   T12BA_XENLA             Reviewed;         335 AA.
AC   Q5EAX9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Transmembrane protein 120B-A;
GN   Name=tmem120b-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC       channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC090205; AAH90205.1; -; mRNA.
DR   RefSeq; NP_001089276.1; NM_001095807.1.
DR   AlphaFoldDB; Q5EAX9; -.
DR   SMR; Q5EAX9; -.
DR   DNASU; 734324; -.
DR   GeneID; 734324; -.
DR   KEGG; xla:734324; -.
DR   CTD; 734324; -.
DR   Xenbase; XB-GENE-6087423; tmem120b.L.
DR   OMA; YGFQAYN; -.
DR   OrthoDB; 916768at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 734324; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Transmembrane protein 120B-A"
FT                   /id="PRO_0000309532"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          1..40
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  39812 MW;  F109CF31E1493D60 CRC64;
     MSLQKCQEEW SEIEKEFQQL QETHKVYKQK LEELNSLQNL CSSCINKHKR RLTEFKGNLH
     GLKRTSNLEE KELVQQIDGT IKERRNAFFD MEAYLPKKNG LYLNLVLGNV NVTLLSTQAK
     FAYKDEYEKF KLYLTIILLL GAITCRFVLN YRVTDEVFNF LLVWYYCTLT IRESILISNG
     SRIKGWWVSH HYVSTFLSGV MLTWPDGLMY QIFRNQFLAF SIFQSCVQFL QYYYQSGCLY
     RLRALGERNH LDLTVEGFQS WMWRGLTFLL PFLFFGHFWQ LYNAITLFGL SRHDACKEWQ
     VFVLALTFLL LFLGNFLTTL KVVHTKFQKN KLKKP