ID   T12BB_XENLA             Reviewed;         335 AA.
AC   Q6DE21;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Transmembrane protein 120B-B;
GN   Name=tmem120b-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC       channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
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DR   EMBL; BC077325; AAH77325.1; -; mRNA.
DR   RefSeq; NP_001086700.1; NM_001093231.1.
DR   AlphaFoldDB; Q6DE21; -.
DR   SMR; Q6DE21; -.
DR   MaxQB; Q6DE21; -.
DR   DNASU; 446535; -.
DR   GeneID; 446535; -.
DR   KEGG; xla:446535; -.
DR   CTD; 446535; -.
DR   Xenbase; XB-GENE-17339337; tmem120b.S.
DR   OMA; FFLNYRV; -.
DR   OrthoDB; 916768at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 446535; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433; PTHR21433; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Transmembrane protein 120B-B"
FT                   /id="PRO_0000309533"
FT   TRANSMEM        100..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          1..39
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  39984 MW;  66B75AC8F59E1750 CRC64;
     MSLQKCQEEW GELEKEFQQL QETHKVYKQK LEELSSLQNL CSSYINKHKR RLTELKGNLH
     GYKHTSNLEE KELIQQIDGT IKERHNAFFD MEAYLPKKNS LYLNLVLGNV NVTLLSKQTK
     FAYKDEYEKF KLYLTIILLL GAITCRFVLH YRVTDEVFNF LLVWYFCTLT IRESILISNG
     SRIKGWWVSH HYVSTFLSGV MLTWPDGLMY QMFRNQFLAF SIFQSCVQFL QYYYQSGCLY
     RLRALGERNH LHLTVEGFQS WMWRGLTFLL PVLFFGHFWQ LYNAMTLFGL SRHEECKEWQ
     VFVLALTFLL LFLGNFLTTL KVVHTKFQKN KLKKP