T131L_BOVIN
ID T131L_BOVIN Reviewed; 1598 AA.
AC Q08DV9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Transmembrane protein 131-like;
DE Flags: Precursor;
GN Name=TMEM131L {ECO:0000250|UniProtKB:A2VDJ0};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM131 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI23546.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC123545; AAI23546.1; ALT_INIT; mRNA.
DR RefSeq; NP_001070271.2; NM_001076803.1.
DR AlphaFoldDB; Q08DV9; -.
DR SMR; Q08DV9; -.
DR STRING; 9913.ENSBTAP00000049631; -.
DR PaxDb; Q08DV9; -.
DR PRIDE; Q08DV9; -.
DR GeneID; 505156; -.
DR KEGG; bta:505156; -.
DR CTD; 23240; -.
DR eggNOG; KOG3620; Eukaryota.
DR HOGENOM; CLU_004094_0_0_1; -.
DR OrthoDB; 45814at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR039877; TMEM131-like.
DR InterPro; IPR045695; TMEM131-like_conserved.
DR InterPro; IPR022113; TMEM131-like_N.
DR PANTHER; PTHR22050; PTHR22050; 1.
DR Pfam; PF19532; TMEM131_like; 1.
DR Pfam; PF12371; TMEM131_like_N; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..40
FT /evidence="ECO:0000255"
FT CHAIN 41..1598
FT /note="Transmembrane protein 131-like"
FT /id="PRO_0000328864"
FT TOPO_DOM 41..868
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 869..889
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 890..1598
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 943..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1254..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1112
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2VDJ0"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 438
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 592
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 648
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 708
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 845
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1598 AA; 174577 MW; 0E7B8C47CB767DA7 CRC64;
MAGPRRPQPG CYRRTAAAVN LLLGVFHVLL PCGRPGGAQG QAIEPMPNVV ELWQAEEGEL
LLPTQGDSED DTEEQSQEQS FSDKLFSGKG LHFQPSVLDF GVQFLGQPAA KILYAYNPSR
ESEVVVNSVF TAARHFHVPP VHCRVIPAMG KTSFRIIFLP TEEGSIESSL FINTSSHGVL
SYHVSGFGTR VMSAKGSAEQ LPNAYFLLPQ VQTVQLSQTQ AETTNSSLLQ VQLECSLHNK
VCQRLKSCYV ESDDVLRLQM SIIVTMENTS KEFEENTQDL LDHLSIIYVA TDKSESSDDS
AVNMYILHSG NSLIWIQDVR HFSQRDVLSL QFEPVLLPTS TTNFTKIASF TCKAPSCESG
AREDGKKKDT PTLKACLSSP VVQGYFRMDP SATQFHIENH ENTSGLWSLW YLNHFDHGVV
LNDVFVSKET KHVLKILNFT GPLFLPPGCW KIFSLKLAVK DIAINVFTHV FLTTNIGAVF
AIPLQIYSAP TKEGSLGFEV IAHCGMHYFM GKSKAENPDW EGSLSLDPST WDVDSELANT
LYERWKKLKH GDVCKRTVLG VTRFAHSKKS KESEPFAVFL PRLVPEPGLV LNFSATALRN
SMVKYFVVKN PSSWPVSLQL LPVSLYPKPE AAARLLHKWF GTDMQMINLT TSEFQLTKAC
PYLGVRSEGS RFGILHLHLQ PLERKRVGVV FTPADYGKVS SLILIRNNLT VIDMIGVEGF
GARELLKVGG RLPGTGGSLR FKVPESTLMD CRRQLKDSKQ ILSITKNFKV ENIGPLPITV
TSLKINGYNC QGYGFEVLDC HQFSLGPNTS RDISIVFTPD FTSSWVIREL TLVTAADLEF
RFTLNVTLPH HLLPLCADVV PGPSWEESFW RLTVFFVSLS LLGVILIAFQ QAQYILMEFM
KTRQRQNASS SSQQSTAPVD VISAHSHKSN CKNFLDAYAP SDKGRGKSCL PVSSPQSRTQ
NATKRSPATC GHSQKKHKCS VYYGRHRGAA VASSAGAPSE DRPAPAKAGG CPAGAGEAWV
GLRCAGGLSA NLQKSLALPR SFLGKDENTL KSAVAASSPS SECHVKEGAQ TCVFPKETDF
QVSESVAELK EREVCPMKTP KKLPENHLPR SSPQCQSDLP DISRKNNGNN QQVPVKNEVD
NCESLKKVDT KSSSEKKIHK AAKEDGCSEK QDIPSIEQED PYRKKALQEK KEGNVQNLNW
NKNRMCRKNK KRGAAQVLRP SDQSELKLVC SEFERSELSS DINVRNWRIQ ENPGEACKAG
ASSGSSLPAT QGEAEGYFQK PGKKGAEKSC SDSGSDCGSS SGSVRASRGS WGSWSSASSS
DGDRKPAVGP PRCLLPGDSV SQNDFSSEAP ISLNLSRNIC NPTDVSGLPA PADAPCPSLP
AGPAAAEEQG LCAPGDLWPA QPVCVTGGFG CALESGGPAA LPPPAAVPSS SFIDWNATCE
GQFPSVYCPL ELNDYNAFPE EGMNYPSGFP CPAEVQTDFI DHSSPSAWGS PPSVPTAWGH
ASLISSPPYL TSTRSLSPMS GLFGSIWAPQ SDVYENCCAI NPTTEHSAHM ENQAVMCKEY
YPGFNPFRAY MDLDIWTSTA NRNANFPLSR DSSYCGNV
