T132B_HUMAN
ID T132B_HUMAN Reviewed; 1078 AA.
AC Q14DG7; A2RRG8; Q8NA73; Q96JN9; Q96PY1;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transmembrane protein 132B;
GN Name=TMEM132B; Synonyms=KIAA1786, KIAA1906;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT VAL-658.
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-1078 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-1078 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q14DG7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14DG7-2; Sequence=VSP_024577, VSP_024578;
CC Name=3;
CC IsoId=Q14DG7-3; Sequence=VSP_024576;
CC -!- SIMILARITY: Belongs to the TMEM132 family. {ECO:0000305}.
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DR EMBL; AC093028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK093097; BAC04053.1; -; mRNA.
DR EMBL; BC113366; AAI13367.1; -; mRNA.
DR EMBL; BC113368; AAI13369.1; -; mRNA.
DR EMBL; BC131621; AAI31622.1; -; mRNA.
DR EMBL; AB058689; BAB47415.1; -; mRNA.
DR EMBL; AB067493; BAB67799.1; -; mRNA.
DR CCDS; CCDS41859.1; -. [Q14DG7-1]
DR CCDS; CCDS66501.1; -. [Q14DG7-3]
DR RefSeq; NP_001273148.1; NM_001286219.1. [Q14DG7-3]
DR RefSeq; NP_443139.2; NM_052907.3. [Q14DG7-1]
DR RefSeq; XP_011536156.1; XM_011537854.2. [Q14DG7-3]
DR AlphaFoldDB; Q14DG7; -.
DR BioGRID; 125357; 1.
DR IntAct; Q14DG7; 2.
DR STRING; 9606.ENSP00000299308; -.
DR GlyGen; Q14DG7; 4 sites.
DR iPTMnet; Q14DG7; -.
DR PhosphoSitePlus; Q14DG7; -.
DR BioMuta; TMEM132B; -.
DR DMDM; 145566963; -.
DR EPD; Q14DG7; -.
DR MassIVE; Q14DG7; -.
DR PaxDb; Q14DG7; -.
DR PeptideAtlas; Q14DG7; -.
DR PRIDE; Q14DG7; -.
DR ProteomicsDB; 60346; -. [Q14DG7-1]
DR ProteomicsDB; 60347; -. [Q14DG7-2]
DR ProteomicsDB; 60348; -. [Q14DG7-3]
DR Antibodypedia; 31916; 41 antibodies from 17 providers.
DR DNASU; 114795; -.
DR Ensembl; ENST00000299308.7; ENSP00000299308.3; ENSG00000139364.11. [Q14DG7-1]
DR Ensembl; ENST00000613307.1; ENSP00000482788.1; ENSG00000139364.11. [Q14DG7-3]
DR GeneID; 114795; -.
DR KEGG; hsa:114795; -.
DR UCSC; uc001uhe.3; human. [Q14DG7-1]
DR CTD; 114795; -.
DR DisGeNET; 114795; -.
DR GeneCards; TMEM132B; -.
DR HGNC; HGNC:29397; TMEM132B.
DR HPA; ENSG00000139364; Tissue enriched (brain).
DR neXtProt; NX_Q14DG7; -.
DR OpenTargets; ENSG00000139364; -.
DR PharmGKB; PA143485652; -.
DR VEuPathDB; HostDB:ENSG00000139364; -.
DR eggNOG; KOG4789; Eukaryota.
DR GeneTree; ENSGT00940000159630; -.
DR HOGENOM; CLU_009871_0_0_1; -.
DR InParanoid; Q14DG7; -.
DR OMA; CTGGVTE; -.
DR OrthoDB; 598074at2759; -.
DR PhylomeDB; Q14DG7; -.
DR TreeFam; TF314981; -.
DR PathwayCommons; Q14DG7; -.
DR BioGRID-ORCS; 114795; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; TMEM132B; human.
DR GenomeRNAi; 114795; -.
DR Pharos; Q14DG7; Tdark.
DR PRO; PR:Q14DG7; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q14DG7; protein.
DR Bgee; ENSG00000139364; Expressed in ventricular zone and 122 other tissues.
DR Genevisible; Q14DG7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388; PTHR13388; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1078
FT /note="Transmembrane protein 132B"
FT /id="PRO_0000284620"
FT TOPO_DOM 1..903
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 925..1078
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 834..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 366
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..488
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_024576"
FT VAR_SEQ 476..502
FT /note="SNNCDSIFVNGKEMKSKVDTIVNFTHQ -> RGDLSTAVLSAQSFLSFLLLS
FT PRSCSH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_024577"
FT VAR_SEQ 503..1078
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11347906"
FT /id="VSP_024578"
FT VARIANT 658
FT /note="A -> V (in dbSNP:rs16919359)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031786"
FT CONFLICT 735
FT /note="V -> G (in Ref. 2; BAC04053)"
FT /evidence="ECO:0000305"
FT CONFLICT 957
FT /note="N -> D (in Ref. 2; BAC04053)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1078 AA; 119477 MW; 05119ADDA42AF379 CRC64;
MFGAASRMDT TAVCTGGVTE SRGIVDSLQK FSSLPAYLPT NLHISNAEES FFLKEANQDL
TRNSSLQARV EPFFIYRART PPIINASYGP FSVEKIIPQE LLLTSTAFGN MDKFPFNWKL
KSHILDSSIY SNRPKVQTLF YVTGMGWDDS DLTEDLPCVK MFAFPEAREV AASCRLQGAP
GLCVAELELL PEWFSSGLDL EPEEEIPALL GGTTMELFFT LYPADKAGQC PLEEEGKWEN
NIHSGLESPQ QAFPARERIG SVVVYPTQDD LKWSLVSLDE NVVISVPLNL VREGDTATFL
VSLTSSSVAD QFTLRIKAAA GVKITAVRVS SEDQWAVQEE IDNGSTQTSA TLTCMGHRPD
TQSRVNGSFY EILQVDFGID NSSDLAGAQQ ITWQVEYPIE DSMSELVVSE IFVSQTTFVG
IVPLAMDTEV LNTAILTGKP VSVPVKVVGV QEDGSVVDVS ESVECKSADE DVIKVSNNCD
SIFVNGKEMK SKVDTIVNFT HQHFTSQFEV TVWAPRLPLQ IEISDTELSQ IKGWRIPVAA
NRRPTRESDD EDDEEKKGRG CSLQYQHATV RVLTQFVAES PDLGQLTYML GPDWQFDITD
LVTEFMKVEE PKIAQLQDGR TLAGREPGIT TVQVLSPLSD SILAEKTVIV LDDRVTIAEL
GVQLVAGMSL SLQPHRADKR AIVSTAAALD VLQSPQQEAI VSSWILFSDG SVTPLDIYDP
KDYSVTVSSL DEMVVSVQAN LESKWPIVVA EGEGQGPLIK LEMMISEPCQ KTKRKSVLAV
GKGNVKVKFE PSSDEHQGGS NDIEGINREY KDHLSNSIER EGNQERAVQE WFHRGTPVGQ
EESTNKSTTP QSPMEGKNKL LKSGGPDAFT SFPTQGKSPD PNNPSDLTVT SRGLTDLEIG
MYALLCVFCL AILVFLINCV AFAWKYRHKR FAVSEQGNIP HSHDWVWLGN EVELLENPVD
ITLPSEECTT MIDRGLQFEE RNFLLNGSSQ KTFHSQLLRP SDYVYEKEIK NEPMNSSGPK
RKRVKFTSYT TILPEDGGPY TNSILFDSDD NIKWVCQDMG LGDSQDFRDY MESLQDQM
