T132C_HUMAN
ID T132C_HUMAN Reviewed; 1108 AA.
AC Q8N3T6; Q69YX8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 3.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane protein 132C;
DE Flags: Precursor;
GN Name=TMEM132C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-1108.
RC TISSUE=Amygdala, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM132 family. {ECO:0000305}.
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DR EMBL; AC023595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC061709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC126612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL122107; CAH10715.1; -; mRNA.
DR EMBL; AL831921; CAD38581.1; -; mRNA.
DR CCDS; CCDS45009.2; -.
DR RefSeq; NP_001129575.2; NM_001136103.2.
DR AlphaFoldDB; Q8N3T6; -.
DR BioGRID; 124930; 2.
DR IntAct; Q8N3T6; 4.
DR STRING; 9606.ENSP00000410852; -.
DR GlyGen; Q8N3T6; 3 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N3T6; -.
DR PhosphoSitePlus; Q8N3T6; -.
DR BioMuta; TMEM132C; -.
DR DMDM; 288558838; -.
DR MassIVE; Q8N3T6; -.
DR PaxDb; Q8N3T6; -.
DR PeptideAtlas; Q8N3T6; -.
DR PRIDE; Q8N3T6; -.
DR ProteomicsDB; 71834; -.
DR Antibodypedia; 2660; 15 antibodies from 7 providers.
DR DNASU; 92293; -.
DR Ensembl; ENST00000435159.3; ENSP00000410852.2; ENSG00000181234.10.
DR GeneID; 92293; -.
DR KEGG; hsa:92293; -.
DR MANE-Select; ENST00000435159.3; ENSP00000410852.2; NM_001136103.3; NP_001129575.2.
DR UCSC; uc021rgn.1; human.
DR CTD; 92293; -.
DR DisGeNET; 92293; -.
DR GeneCards; TMEM132C; -.
DR HGNC; HGNC:25436; TMEM132C.
DR HPA; ENSG00000181234; Tissue enhanced (adipose).
DR neXtProt; NX_Q8N3T6; -.
DR OpenTargets; ENSG00000181234; -.
DR PharmGKB; PA143485653; -.
DR VEuPathDB; HostDB:ENSG00000181234; -.
DR eggNOG; KOG4789; Eukaryota.
DR GeneTree; ENSGT00940000154702; -.
DR HOGENOM; CLU_009871_0_0_1; -.
DR InParanoid; Q8N3T6; -.
DR OMA; HGVTDNI; -.
DR OrthoDB; 598074at2759; -.
DR PhylomeDB; Q8N3T6; -.
DR TreeFam; TF314981; -.
DR PathwayCommons; Q8N3T6; -.
DR SignaLink; Q8N3T6; -.
DR BioGRID-ORCS; 92293; 6 hits in 220 CRISPR screens.
DR ChiTaRS; TMEM132C; human.
DR GenomeRNAi; 92293; -.
DR Pharos; Q8N3T6; Tdark.
DR PRO; PR:Q8N3T6; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N3T6; protein.
DR Bgee; ENSG00000181234; Expressed in decidua and 153 other tissues.
DR Genevisible; Q8N3T6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388; PTHR13388; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..1108
FT /note="Transmembrane protein 132C"
FT /id="PRO_0000324577"
FT TOPO_DOM 28..922
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 923..943
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 944..1108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 820..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 373
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 161
FT /note="H -> R (in dbSNP:rs11059681)"
FT /id="VAR_039832"
FT VARIANT 232
FT /note="V -> M (in dbSNP:rs12307622)"
FT /id="VAR_039833"
FT VARIANT 272
FT /note="V -> I (in dbSNP:rs1683723)"
FT /id="VAR_039834"
FT VARIANT 444
FT /note="V -> I (in dbSNP:rs4272850)"
FT /id="VAR_039835"
FT VARIANT 730
FT /note="T -> S (in dbSNP:rs12426596)"
FT /id="VAR_039836"
FT VARIANT 799
FT /note="F -> I (in dbSNP:rs12301587)"
FT /id="VAR_039837"
FT VARIANT 810
FT /note="G -> R (in dbSNP:rs12424159)"
FT /id="VAR_039838"
SQ SEQUENCE 1108 AA; 121787 MW; FB0298520B3AAE2B CRC64;
MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP VSYHILRAET
SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG PFSVEKVVPL DLMLTSNFLG
PTNKFSFDWK LKAHILRDKV YLSRPKVQVL FHIMGRDWDD HGAGEKLPCL RVFAFRETRE
VRGSCRLKGD LGLCVAELEL LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD
CAGGDFRKGN AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP
VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE VGSGGKHVTA
TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP ITWQVEYPRK GTTDIAVSEI
FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV AMPIKVVSVE ENSAVMDISE SVECKSTDED
VIKVSERCDY IFVNGKEIKG KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI
KGWRVPIVTN KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL
SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD SILAEKTITV
LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE VLRTPKQEAV FSTWLQFSDG
SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ
KSKRKSILAV GVGNVRVKFG QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL
YGSSPVEREE GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD
LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL KYRHKQVPLE
GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR GPGACEESNH LLLNGGSHKH
VQSQIHRSAD SGGRQGREQK QDPLHSPTSK RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE
DIKWVCQDVA VGAPKELRNY LEKLKDKA
