T132C_MOUSE
ID T132C_MOUSE Reviewed; 1099 AA.
AC Q8CEF9; Q8BS69;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 3.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Transmembrane protein 132C;
DE Flags: Precursor;
GN Name=Tmem132c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic breast, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM132 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25861.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC28926.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK028289; BAC25861.1; ALT_INIT; mRNA.
DR EMBL; AK035053; BAC28926.1; ALT_INIT; mRNA.
DR RefSeq; NP_780641.2; NM_175432.3.
DR AlphaFoldDB; Q8CEF9; -.
DR STRING; 10090.ENSMUSP00000113090; -.
DR GlyGen; Q8CEF9; 3 sites.
DR PhosphoSitePlus; Q8CEF9; -.
DR MaxQB; Q8CEF9; -.
DR PaxDb; Q8CEF9; -.
DR PRIDE; Q8CEF9; -.
DR ProteomicsDB; 263212; -.
DR GeneID; 208213; -.
DR KEGG; mmu:208213; -.
DR CTD; 92293; -.
DR MGI; MGI:2443061; Tmem132c.
DR eggNOG; KOG4789; Eukaryota.
DR InParanoid; Q8CEF9; -.
DR OrthoDB; 598074at2759; -.
DR PhylomeDB; Q8CEF9; -.
DR BioGRID-ORCS; 208213; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem132c; mouse.
DR PRO; PR:Q8CEF9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8CEF9; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388; PTHR13388; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..1099
FT /note="Transmembrane protein 132C"
FT /id="PRO_0000287099"
FT TOPO_DOM 32..915
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 916..936
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 937..1099
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 237..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 371
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1099 AA; 121378 MW; D34966E5BC4DC3CF CRC64;
MRSEGAAPRR AARYGALSLV LATLLGQVTE SRGVMDNIQR FSSLPPYLPV SFHVLRAETA
FFLKEANPDP LRNASLQSRV ESFFIYKAQQ PPVLNVSYGP YSAEKVIPLD LMLNPNFLGP
TSKFPFDWRL KAYILQEKVY LSHPKVQVLF HIVGRDWDDH RDEKLPCLRV FAFRDSREVR
GSCRLGGPLG LCVAQLEMLP GWFSPPAVVS GRRRPAERPE GSPVELYYAV QPGDERGDCT
GGDTRKDNAI RPGKDGQEGR TSHLQKIGTI SLYRAQDSNQ LSELRLDGNV VIWLPSQPVK
QGDIVTASVT IANNSTVDHF ILRAKVKKGV NILTVQTSEP RQWDVRQEVG NGGKHTTTSV
ACQRLGPGAR NRSSNLFSEV MQMNFEIASF SSLSGTQPIT WQVEYPRKGA TDIAVSEIFI
SQKDLVAIVP LAMDTELLNT AILTGKTVAM PVRVVSVEEN STLRDISELV ECKATDENVI
KVSDHCDYVF VNGKEIKGKM DSVVNFTYQH LSAPLHVTVW VPRLPLQIEV SDTELSQVKG
WRVPIVASKR PTRDSEEEEE EEQKGRGCTL QFQHATVRVL TQFVSEGAGP WGQLSHLLSP
DWQFDITHLV ADFMKLESPH IATLQDSRVL VGREVGMTTI QVLSPLSDSI LAEKTVTVLD
DKVSVTDLAV QVVAGLSVTL HPISENNKAT SAVAMAEELL RAPKKEAIIS TWLQFSDGSV
TPLDIYDSKD FSLTAISLDE AVVSIPQPLS PWWPTVVAEG EGQGPLLRVD MSIAEACQKS
KRKSVLAVGI GHVGVKFGWD DADSSQTGEK DEEEIKNHAS DRRQKIQDLE RPGQDELYHG
NFPGDREEGA LSATTTTKSL LDNNVGKSGR RDGARLHSIP IDFTNFPAHV DLPKAKTRGT
LEENGLMQTA HGLSDLEIGM YALLGVFCLA ILVFLINCAT FAFKYRHKQV PLEGQASMTH
SHDWVWLGNE AELLENIGDL SPPQDEHTTI IDRGLGGCEE NNHLLLNGGS QKPTQSQVHR
PPGSGGRQTR EPRQEPANSP TSKMKKVKFA TFTIPPEESC PTVNSILSGE DDIKWVCQDL
DVGAPKELRT YLEKFQDSV
