T132D_HUMAN
ID T132D_HUMAN Reviewed; 1099 AA.
AC Q14C87; Q14C96; Q76M59; Q8N1W9; Q8N3Q5; Q8TF57;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 132D;
DE AltName: Full=Mature oligodendrocytes transmembrane protein;
DE Short=Mature OL transmembrane protein;
DE Flags: Precursor;
GN Name=TMEM132D; Synonyms=HBE120, KIAA1944, MOLT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12966072; DOI=10.1093/jb/mvg135;
RA Nomoto H., Yonezawa T., Itoh K., Ono K., Yamamoto K., Oohashi T.,
RA Shiraga F., Ohtsuki H., Ninomiya Y.;
RT "Molecular cloning of a novel transmembrane protein MOLT expressed by
RT mature oligodendrocytes.";
RL J. Biochem. 134:231-238(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 851-1099 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 947-1099 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May serve as a cell-surface marker for oligodendrocyte
CC differentiation. {ECO:0000269|PubMed:12966072}.
CC -!- INTERACTION:
CC Q14C87; P62136: PPP1CA; NbExp=2; IntAct=EBI-5235567, EBI-357253;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14C87-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14C87-2; Sequence=VSP_025307, VSP_025308;
CC -!- TISSUE SPECIFICITY: Expressed in mature oligodendrocytes. Detected in
CC the brain, lung, pancreas and testis. {ECO:0000269|PubMed:12966072}.
CC -!- SIMILARITY: Belongs to the TMEM132 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85530.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB061814; BAC97794.1; -; mRNA.
DR EMBL; AB075824; BAB85530.1; ALT_INIT; mRNA.
DR EMBL; BC114626; AAI14627.1; -; mRNA.
DR EMBL; BC114936; AAI14937.1; -; mRNA.
DR EMBL; AL833234; CAD38636.1; -; mRNA.
DR EMBL; AK094656; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS9266.1; -. [Q14C87-1]
DR RefSeq; NP_597705.2; NM_133448.2. [Q14C87-1]
DR AlphaFoldDB; Q14C87; -.
DR SMR; Q14C87; -.
DR BioGRID; 125713; 1.
DR IntAct; Q14C87; 1.
DR STRING; 9606.ENSP00000408581; -.
DR GlyGen; Q14C87; 1 site.
DR iPTMnet; Q14C87; -.
DR PhosphoSitePlus; Q14C87; -.
DR BioMuta; TMEM132D; -.
DR DMDM; 121940538; -.
DR jPOST; Q14C87; -.
DR MassIVE; Q14C87; -.
DR PaxDb; Q14C87; -.
DR PeptideAtlas; Q14C87; -.
DR PRIDE; Q14C87; -.
DR ProteomicsDB; 60314; -. [Q14C87-1]
DR ProteomicsDB; 60315; -. [Q14C87-2]
DR TopDownProteomics; Q14C87-2; -. [Q14C87-2]
DR Antibodypedia; 19379; 94 antibodies from 19 providers.
DR DNASU; 121256; -.
DR Ensembl; ENST00000389441.8; ENSP00000374092.4; ENSG00000151952.16. [Q14C87-2]
DR Ensembl; ENST00000422113.7; ENSP00000408581.2; ENSG00000151952.16. [Q14C87-1]
DR GeneID; 121256; -.
DR KEGG; hsa:121256; -.
DR MANE-Select; ENST00000422113.7; ENSP00000408581.2; NM_133448.3; NP_597705.2.
DR UCSC; uc001uia.3; human. [Q14C87-1]
DR CTD; 121256; -.
DR DisGeNET; 121256; -.
DR GeneCards; TMEM132D; -.
DR HGNC; HGNC:29411; TMEM132D.
DR HPA; ENSG00000151952; Tissue enriched (brain).
DR MIM; 611257; gene.
DR neXtProt; NX_Q14C87; -.
DR OpenTargets; ENSG00000151952; -.
DR PharmGKB; PA143485654; -.
DR VEuPathDB; HostDB:ENSG00000151952; -.
DR eggNOG; KOG4789; Eukaryota.
DR GeneTree; ENSGT00940000158942; -.
DR HOGENOM; CLU_009871_2_0_1; -.
DR InParanoid; Q14C87; -.
DR OMA; PFGFTNK; -.
DR OrthoDB; 598074at2759; -.
DR PhylomeDB; Q14C87; -.
DR TreeFam; TF314981; -.
DR PathwayCommons; Q14C87; -.
DR SignaLink; Q14C87; -.
DR BioGRID-ORCS; 121256; 18 hits in 1061 CRISPR screens.
DR ChiTaRS; TMEM132D; human.
DR GenomeRNAi; 121256; -.
DR Pharos; Q14C87; Tbio.
DR PRO; PR:Q14C87; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q14C87; protein.
DR Bgee; ENSG00000151952; Expressed in middle temporal gyrus and 61 other tissues.
DR Genevisible; Q14C87; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388; PTHR13388; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..1099
FT /note="Transmembrane protein 132D"
FT /id="PRO_0000287100"
FT TOPO_DOM 31..915
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 916..936
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 937..1099
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 797..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..462
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11853319"
FT /id="VSP_025307"
FT VAR_SEQ 463..481
FT /note="VTELLESVECRSSDEDVIK -> MQRDESSPFPPLFSLTSSQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11853319"
FT /id="VSP_025308"
FT VARIANT 436
FT /note="E -> Q (in dbSNP:rs12816729)"
FT /id="VAR_053887"
FT VARIANT 460
FT /note="D -> H (in dbSNP:rs12816538)"
FT /id="VAR_053888"
FT VARIANT 878
FT /note="L -> F (in dbSNP:rs555131)"
FT /id="VAR_032264"
FT CONFLICT 696
FT /note="A -> T (in Ref. 1; BAC97794)"
FT /evidence="ECO:0000305"
FT CONFLICT 831
FT /note="S -> L (in Ref. 3; AAI14627)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1099 AA; 122309 MW; 4BA360835180F7B3 CRC64;
MCPSEMGTLW HHWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT YHINNADVSF
FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF SIEQVVPQDL MLPSNPFGFT
NKFSLNWKLK AHILRDKVYL SRPKVQVLFH IMGRDWDDRS AGEKLPCLRV FAFRETREVR
GSCRLQGDLG LCVAELELLS SWFSPPTVVA GRRKSVDQPE GTPVELYYTV HPGGERGDCV
REDARRSNGI RTGHSDIDES GPPLQRIGSI FLYQTHRKPS LRELRLDNSV AIHYIPKTVR
KGDVLTFPVS ISRNSTEDRF TLRAKVKKGV NIIGVRASSP SIWDVKERTD YTGKYAPAVI
VCQKKAAGSE NSADGASYEV MQIDVEVEEP GDLPATQLVT WQVEYPGEIT SDLGVSKIYV
SPKDLIGVVP LAMEAEILNT AILTGKTVAV PVKVVSVEDD GTVTELLESV ECRSSDEDVI
KVSDRCDYVF VNGKEMKGKV NVVVNFTYQH LSSPLEMTVW VPRLPLQIEV SDTELNQIKG
WRVPIVSSRR PAGDSEEEED DERRGRGCTL QYQHAMVRVL TQFVAEAAGP GGHLAHLLGS
DWQVDITELI NDFMQVEEPR IAKLQGGQIL MGQELGMTTI QILSPLSDTI LAEKTITVLD
EKVTITDLGV QLVTGLSLSL QLSPGSNRAI FATAVAQELL QRPKQEAAIS CWVQFSDGSV
TPLDIYDGKD FSLMATSLDE KVVSIHQDPK FKWPIIAAET EGQGTLVKVE MVISESCQKS
KRKSVLAVGT ANIKVKFGQN DANPNTSDSR HTGAGVHMEN NVSDRRPKKP SQEWGSQEGQ
YYGSSSMGLM EGRGTTTDRS ILQKKKGQES LLDDNSHLQT IPSDLTSFPA QVDLPRSNGE
MDGNDLMQAS KGLSDLEIGM YALLGVFCLA ILVFLINCVT FALKYRHKQV PFEEQEGMSH
SHDWVGLSNR TELLENHINF ASSQDEQITA IDRGMDFEES KYLLSTNSQK SINGQLFKPL
GPIIIDGKDQ KSEPPTSPTS KRKRVKFTTF TAVSSDDEYP TRNSIVMSSE DDIKWVCQDL
DPGDCKELHN YMERLHENV
