T132D_MOUSE
ID T132D_MOUSE Reviewed; 1097 AA.
AC Q76HP3; B2RU39; Q8C422;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Transmembrane protein 132D;
DE AltName: Full=Mature oligodendrocytes transmembrane protein;
DE Short=Mature OL transmembrane protein;
DE Flags: Precursor;
GN Name=Tmem132d; Synonyms=Molt;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12966072; DOI=10.1093/jb/mvg135;
RA Nomoto H., Yonezawa T., Itoh K., Ono K., Yamamoto K., Oohashi T.,
RA Shiraga F., Ohtsuki H., Ninomiya Y.;
RT "Molecular cloning of a novel transmembrane protein MOLT expressed by
RT mature oligodendrocytes.";
RL J. Biochem. 134:231-238(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May serve as a cell-surface marker for oligodendrocyte
CC differentiation. {ECO:0000269|PubMed:12966072}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in mature oligodendrocytes in the white
CC and gray matter of the brain. {ECO:0000269|PubMed:12966072}.
CC -!- SIMILARITY: Belongs to the TMEM132 family. {ECO:0000305}.
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DR EMBL; AB100355; BAC97815.1; -; mRNA.
DR EMBL; AK083210; BAC38810.1; -; mRNA.
DR EMBL; BC140953; AAI40954.1; -; mRNA.
DR CCDS; CCDS39287.1; -.
DR RefSeq; NP_766473.1; NM_172885.2.
DR AlphaFoldDB; Q76HP3; -.
DR STRING; 10090.ENSMUSP00000043633; -.
DR iPTMnet; Q76HP3; -.
DR PhosphoSitePlus; Q76HP3; -.
DR PaxDb; Q76HP3; -.
DR PRIDE; Q76HP3; -.
DR ProteomicsDB; 254521; -.
DR DNASU; 243274; -.
DR GeneID; 243274; -.
DR KEGG; mmu:243274; -.
DR UCSC; uc008zse.1; mouse.
DR CTD; 121256; -.
DR MGI; MGI:3044963; Tmem132d.
DR eggNOG; KOG4789; Eukaryota.
DR InParanoid; Q76HP3; -.
DR OrthoDB; 598074at2759; -.
DR PhylomeDB; Q76HP3; -.
DR TreeFam; TF314981; -.
DR BioGRID-ORCS; 243274; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem132d; mouse.
DR PRO; PR:Q76HP3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q76HP3; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026307; TMEM132.
DR InterPro; IPR031436; TMEM132_C.
DR InterPro; IPR031437; TMEM132_M.
DR InterPro; IPR031435; TMEM132_N.
DR PANTHER; PTHR13388; PTHR13388; 1.
DR Pfam; PF16070; TMEM132; 1.
DR Pfam; PF15706; TMEM132D_C; 1.
DR Pfam; PF15705; TMEM132D_N; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..1097
FT /note="Transmembrane protein 132D"
FT /id="PRO_0000287101"
FT TOPO_DOM 31..913
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 914..934
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 935..1097
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 233..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 426
FT /note="G -> E (in Ref. 2; BAC38810)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1097 AA; 121416 MW; 96513A6D1E98B889 CRC64;
MCPSEMGTLW YLWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT YHINNADVSF
FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF SLEQVVPQDL MLPSNPFGFT
NTFSLNWRLK AYILQEKVYL SHPKVQVLFH IVGRDWDDHR DENLPCLRVF AFRETREVRG
SCRLGGALGL CVAQLEMLPG WFSPPSVVSG RRRPTEQPEG NPVELYYAVQ PGDERGDCAK
EDSRKSGGTP AGHNDVDESS PPLHRIGSVF LRETPSSPPL KELRLDSNVA VHYVPKTVRQ
GDVLTFPISV SRNCTEDRFT LRAKVKKGVS IVGVRASSSS IWDVRQSTEY TGKYAPAVIV
CQKKSAGSEK SVADASYEVM KIDIEVEAPS DPPTTQLVTW QVEYPGEITS DLGVSKIYVS
QKDLIGVIPL AMEAEILNTA ILTGKTVAVP VKVISVEEDG TVQGLLDSVE CRSSDEDVVK
VSDRCDYVFV NGKEMKGKVN VVVSFTYQHL SSPLEMTVWV PRLPLQIEVS DMELNQIKGW
RVPIVSNKRP ARDSEEEDDD EKKGRGCTLQ YQHAMVRVLT QFVAEAPDPG GHLAYLLGSD
WQVDITELIT DFMQVEEPRI AKLQGGQILT GQELGMTTIQ ILSPLSDAIL AEKTITVLDE
KVTITDLGVQ LVTGLSLSLQ LSPGSNRAIF ATAMAQELLQ RPKQEAAISC WVQFSDGSVT
PLDIYDEKDF SLMATSLDEK VVSILQDPKF KWPIIAAENE GQGALVKVEM LISESCQKSK
RKSVLAVGTA SIKVKFGQND ANPNSSESGH LGAGLHVENI NDRRSKKPFQ EWGSPEGPFY
SSSSMGLMEG WGSTTKRPTF QKKEGQENLL DDIILSQTMA TDLTSFPDQM DLPGSNVGTE
EHDLDQAAKG LSDLEIGMYA LLGVFCLAIL VFLINCVTFA LKYRHKQVPF EEQEGLSHSH
DWVGLSNRTE LLGNHMNFAS SQEEQITAID RGLDFEESKL LLSSNSQNSI NGQMFRSTGA
MLTDDQEQKS EPPTSPTSKR KRVTFSTFSA ISSDDGCPSG NTMVLSNEDD IKWVCQGLDP
GECTEPHSCM ERLHEHV
