ID   T132D_RAT               Reviewed;        1097 AA.
AC   Q76HP2;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Transmembrane protein 132D;
DE   AltName: Full=Mature oligodendrocytes transmembrane protein;
DE            Short=Mature OL transmembrane protein;
DE   Flags: Precursor;
GN   Name=Tmem132d; Synonyms=Molt;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RX   PubMed=12966072; DOI=10.1093/jb/mvg135;
RA   Nomoto H., Yonezawa T., Itoh K., Ono K., Yamamoto K., Oohashi T.,
RA   Shiraga F., Ohtsuki H., Ninomiya Y.;
RT   "Molecular cloning of a novel transmembrane protein MOLT expressed by
RT   mature oligodendrocytes.";
RL   J. Biochem. 134:231-238(2003).
CC   -!- FUNCTION: May serve as a cell-surface marker for oligodendrocyte
CC       differentiation. {ECO:0000269|PubMed:12966072}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in mature oligodendrocytes in the brain.
CC       {ECO:0000269|PubMed:12966072}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the course of oligodendrocytes
CC       maturation. {ECO:0000269|PubMed:12966072}.
CC   -!- SIMILARITY: Belongs to the TMEM132 family. {ECO:0000305}.
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DR   EMBL; AB100356; BAC97816.1; -; mRNA.
DR   RefSeq; NP_942022.1; NM_198727.1.
DR   AlphaFoldDB; Q76HP2; -.
DR   STRING; 10116.ENSRNOP00000011181; -.
DR   PaxDb; Q76HP2; -.
DR   PRIDE; Q76HP2; -.
DR   GeneID; 288750; -.
DR   KEGG; rno:288750; -.
DR   UCSC; RGD:735062; rat.
DR   CTD; 121256; -.
DR   RGD; 735062; Tmem132d.
DR   eggNOG; KOG4789; Eukaryota.
DR   InParanoid; Q76HP2; -.
DR   OrthoDB; 598074at2759; -.
DR   PhylomeDB; Q76HP2; -.
DR   PRO; PR:Q76HP2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; TAS:RGD.
DR   InterPro; IPR026307; TMEM132.
DR   InterPro; IPR031436; TMEM132_C.
DR   InterPro; IPR031437; TMEM132_M.
DR   InterPro; IPR031435; TMEM132_N.
DR   PANTHER; PTHR13388; PTHR13388; 1.
DR   Pfam; PF16070; TMEM132; 1.
DR   Pfam; PF15706; TMEM132D_C; 1.
DR   Pfam; PF15705; TMEM132D_N; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..1097
FT                   /note="Transmembrane protein 132D"
FT                   /id="PRO_0000287102"
FT   TOPO_DOM        31..913
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        914..934
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        935..1097
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          206..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          885..906
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1021..1042
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1022..1036
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1097 AA;  121279 MW;  B940D8E8FF2CEE70 CRC64;
     MCPSEMGTLW YLWSPVLISL AALFSKVTEG RGILESIQRF SLLPTYLPVT YHINNADVSF
     FLKEANQDIM RNSSLQSRVE SFLIYKSRRL PVLNASYGPF SLEQVVPQDL MLPSNPFGFT
     NTFSLNWRLK AYILQEKVYL SHPKVQVLFH IVGRDWDDHR DENLPCLRVF AFRETQEVRG
     SCRLGGALGL CVAQLEMLPG WFSPPSVVSG RRRPTEQPEG SPVELYYAVQ PGDERGDCAK
     EDSRKSRGPP AGHNDVDESS PPLHRIGSVF LRETPSSPPL RELRLDSNVA VHYIPKTVRQ
     GDVLTFPISV SRNCTEDRFT LRAKVKKGVS IVGVRASTSS LWDVKQSTEY TGKYAPAVII
     CQKKSAGSGK SVDDASYEVM KIDIEVEAPS DPPTTQLVTW QVEYPGEITS DLGVSKIYVS
     QKDLIGVIPL AMEAEILNTA ILTGKTVAVP VKVISVEEDG TVQGLSDSVE CRSSDEDVVK
     VSDRCDYVFV NGKEMKGKVN VVVTITYQHL SSPLEMTVWV PRLPLQIEVS DMELNQIKGW
     RVPVVSNKRP ARDSEEEDDD EKRGRGCTLQ YQHAMVRVLT QFVAEAPDPG GHLAHLLGSD
     WQVDITELIT DFMQVEEPRI AKLQGGQILT GQELGMTTIQ ILSPLSDAIL AEKTITVLDE
     KVTITDLGVQ LVTGLSLSLQ LSPGSNRAIF ATAVAQELLQ RPKQEAAISC WVQFSDGSVT
     PLDIYDEKDF SLMATSLDEK VVSILQDPKF KWPIIAAENE GQGALVKVEM LISESCQKSK
     RKSVLAVGTA SIKVKFGQND ANPNGSESGH LGAGLHVENI NDRRSKKPFQ EWGSPEGPYY
     SSSSMGLMEG WGSTTKRPTF PKKEGQENLL DDIILSQTMA TDLTSFPDQV DLPGSNVGTE
     EHDPDQAAKG LSDLEIGMYA LLGVFCLAIL VFLINCVTFA LKYRHKQVPF EEQEGLSHSH
     DWVGLSNRTE LLGNHMNFAS SQEEQITAID RGLDFEESKL LLSSNSQNSI NGQLFRSTGA
     MLTDDKEQKS EPPTSPTSKR KRVTFSTFSA ISSDDGCPSG NTMVLSNEDD IKWVCQALDP
     GECPEPHSCM ERLHEHV