T150A_XENTR
ID T150A_XENTR Reviewed; 271 AA.
AC Q28BP2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Transmembrane protein 150A;
DE AltName: Full=Transmembrane protein 150;
GN Name=tmem150a; Synonyms=tmem150; ORFNames=TEgg093b02.1, TNeu137l02.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg, and Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates localization of phosphatidylinositol 4-kinase
CC (PI4K) to the plasma membrane. {ECO:0000250|UniProtKB:Q86TG1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86TG1};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86TG1}.
CC -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR EMBL; CR848545; CAJ81852.1; -; mRNA.
DR EMBL; CR942725; CAJ82815.1; -; mRNA.
DR RefSeq; NP_001016894.1; NM_001016894.2.
DR AlphaFoldDB; Q28BP2; -.
DR STRING; 8364.ENSXETP00000036957; -.
DR Ensembl; ENSXETT00000067556; ENSXETP00000075744; ENSXETG00000036936.
DR GeneID; 549648; -.
DR KEGG; xtr:549648; -.
DR CTD; 129303; -.
DR Xenbase; XB-GENE-853147; tmem150a.
DR InParanoid; Q28BP2; -.
DR OrthoDB; 955528at2759; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000036936; Expressed in skeletal muscle tissue and 12 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR InterPro; IPR027315; TMEM150A.
DR PANTHER; PTHR21324:SF6; PTHR21324:SF6; 1.
DR Pfam; PF10277; Frag1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..271
FT /note="Transmembrane protein 150A"
FT /id="PRO_0000274779"
FT TOPO_DOM 1..3
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..75
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..140
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..205
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q86TG1"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 271 AA; 29401 MW; EFDB26847097F378 CRC64;
MTGWIVLPIS LTVFSIPGIW IVYAMAVMNH HVCPVENWTY NLTCTDDNTK AGTPKSCCTL
EDVPLISKCG TYPPESCLFS LIGNVGAFMV VIICLLRYSQ VIEVSQRSWL NTTALIAGCT
NAAGLVMVGN FQVDYAKSLH YIGAGVAFPA GLLFVCLSSI LSYQIAASAL DYWLGHLRVS
LTIVALISLV LSGVFFIQES FLMQHLAAIC EWIFVLDILV FYGTFAYEFG SVSTDTMMAA
LQSSSARSCK SPGSSSTSTH LHCNAERIAM I