ID   T150B_XENTR             Reviewed;         230 AA.
AC   A9JSP6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Modulator of macroautophagy TMEM150B {ECO:0000305};
DE   AltName: Full=Transmembrane protein 150B {ECO:0000250|UniProtKB:A6NC51};
GN   Name=tmem150b {ECO:0000250|UniProtKB:A6NC51};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulator of macroautophagy that causes accumulation of
CC       autophagosomes under basal conditions and enhances autophagic flux (By
CC       similarity). Represses cell death and promotes long-term clonogenic
CC       survival of cells grown in the absence of glucose in a macroautophagy-
CC       independent manner (By similarity). May have some role in extracellular
CC       matrix engulfment or growth factor receptor recycling, both of which
CC       can modulate cell survival (By similarity).
CC       {ECO:0000250|UniProtKB:A6NC51}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A6NC51};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:A6NC51}. Endosome
CC       membrane {ECO:0000250|UniProtKB:A6NC51}; Multi-pass membrane protein
CC       {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane
CC       {ECO:0000250|UniProtKB:A6NC51}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR   EMBL; BC155023; AAI55024.1; -; mRNA.
DR   RefSeq; NP_001015997.1; NM_001015997.2.
DR   RefSeq; XP_012822011.1; XM_012966557.2.
DR   AlphaFoldDB; A9JSP6; -.
DR   STRING; 8364.ENSXETP00000054331; -.
DR   Ensembl; ENSXETT00000054331; ENSXETP00000054331; ENSXETG00000025504.
DR   GeneID; 548751; -.
DR   KEGG; xtr:548751; -.
DR   CTD; 284417; -.
DR   Xenbase; XB-GENE-5873606; tmem150b.
DR   eggNOG; KOG4320; Eukaryota.
DR   InParanoid; A9JSP6; -.
DR   OrthoDB; 1199230at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025504; Expressed in gastrula and 2 other tissues.
DR   ExpressionAtlas; A9JSP6; differential.
DR   GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Cell membrane; Cytoplasmic vesicle; Endosome; Glycoprotein;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..230
FT                   /note="Modulator of macroautophagy TMEM150B"
FT                   /id="PRO_0000349289"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..50
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..115
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q86TG1"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   230 AA;  25448 MW;  01881839915F329E CRC64;
     MWAWALLPIC LTIWATAGIW IVYGMSVSNG SVNLTDGFPF ISLCGTYPPQ SCVFGQVLNV
     GAMLGVWISV IRFQQIRDYG CHSVLNSVSL AMGLLCALGT SIVGNFQQSN QLETHLAGAF
     LAFVIGNIYF WMQTVLTYMV KPKHGGCYIG PIRFCLSVAC TALIVLMAVF LKLNMKSISA
     ICEWIVAMIL FLLYGLFSVD FWHLDGHYFH VKKRTAIPNE VEVSTVTLNI