T150C_BOVIN
ID T150C_BOVIN Reviewed; 249 AA.
AC A5D7C9; A0JNF6;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Transmembrane protein 150C;
GN Name=TMEM150C;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of a mechanosensitive cation channel. Confers
CC mechanically activated (MA) currents with slow inactivation kinetics.
CC May contribute to proprioception. {ECO:0000250|UniProtKB:Q8C8S3}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B9EJG8};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:B9EJG8}. Lysosome
CC membrane {ECO:0000250|UniProtKB:B9EJG8}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:B9EJG8}. Note=Localizes at the plasma membrane.
CC A portion co-localizes with LAMP1 lysosomal marker.
CC {ECO:0000250|UniProtKB:B9EJG8}.
CC -!- MISCELLANEOUS: Tentonin comes from the Greek 'tentono' meaning to
CC stretch.
CC -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR EMBL; AAFC03076179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126659; AAI26660.1; -; mRNA.
DR EMBL; BC140510; AAI40511.1; -; mRNA.
DR RefSeq; NP_001071469.1; NM_001078001.1.
DR AlphaFoldDB; A5D7C9; -.
DR STRING; 9913.ENSBTAP00000043567; -.
DR PaxDb; A5D7C9; -.
DR Ensembl; ENSBTAT00000046249; ENSBTAP00000043567; ENSBTAG00000032588.
DR Ensembl; ENSBTAT00000080009; ENSBTAP00000069135; ENSBTAG00000032588.
DR Ensembl; ENSBTAT00000083042; ENSBTAP00000066205; ENSBTAG00000032588.
DR GeneID; 534560; -.
DR KEGG; bta:534560; -.
DR CTD; 441027; -.
DR VEuPathDB; HostDB:ENSBTAG00000032588; -.
DR VGNC; VGNC:35982; TMEM150C.
DR eggNOG; KOG4320; Eukaryota.
DR GeneTree; ENSGT01030000234578; -.
DR HOGENOM; CLU_059992_0_1_1; -.
DR InParanoid; A5D7C9; -.
DR OMA; ILMAQDI; -.
DR OrthoDB; 1199230at2759; -.
DR TreeFam; TF314508; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000032588; Expressed in mammary gland fat and 101 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
DR GO; GO:0019230; P:proprioception; ISS:UniProtKB.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR Pfam; PF10277; Frag1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lysosome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..249
FT /note="Transmembrane protein 150C"
FT /id="PRO_0000395031"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..64
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..130
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..192
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q86TG1"
FT CONFLICT 173
FT /note="S -> P (in Ref. 2; AAI26660)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27863 MW; AD2DF964504DC7FD CRC64;
MDGKKCSVWM FLPLVFTVFT SAGLWIVYFI AVEDDKIFPL NSAERKPGVK HAPYISIAGD
EPPASCVFSQ VMNMAAFLAL VVAVLRFIQL KPKVLNPWLN ISGLVALCLA SFGMTLLGNF
QLTNDEEIHN VGTSLTFGFG TLTCWIQAAL TLKVNIKNEG RKVGIPRVIL SASITLCVVL
YFILMAQGIH MYAARVQWGL VMCFLSYFGT FAVEFRHYRY EIVCSEYQEN FLSFSESLSE
ASEYQTDQV
