T150C_HUMAN
ID T150C_HUMAN Reviewed; 249 AA.
AC B9EJG8; B7Z4J5; B7Z4L3; B7Z692; B7Z6X6;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Transmembrane protein 150C;
GN Name=TMEM150C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=25608530; DOI=10.15252/embr.201439151;
RA Chung J., Nakatsu F., Baskin J.M., De Camilli P.;
RT "Plasticity of PI4KIIIalpha interactions at the plasma membrane.";
RL EMBO Rep. 16:312-320(2015).
CC -!- FUNCTION: Component of a mechanosensitive cation channel. Confers
CC mechanically activated (MA) currents with slow inactivation kinetics.
CC May contribute to proprioception. {ECO:0000250|UniProtKB:Q8C8S3}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530};
CC Multi-pass membrane protein {ECO:0000255}. Lysosome membrane
CC {ECO:0000305|PubMed:25608530}; Multi-pass membrane protein
CC {ECO:0000305}. Note=Localizes at the plasma membrane. A portion co-
CC localizes with LAMP1 lysosomal marker (PubMed:25608530).
CC {ECO:0000269|PubMed:25608530}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B9EJG8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B9EJG8-2; Sequence=VSP_039350;
CC -!- MISCELLANEOUS: Tentonin comes from the Greek 'tentono' meaning to
CC stretch. {ECO:0000250|UniProtKB:Q8C8S3}.
CC -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH12581.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK297434; BAH12581.1; ALT_INIT; mRNA.
DR EMBL; AK297512; BAH12599.1; -; mRNA.
DR EMBL; AK299942; BAH13178.1; -; mRNA.
DR EMBL; AK301116; BAH13412.1; -; mRNA.
DR EMBL; AC067942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05896.1; -; Genomic_DNA.
DR EMBL; BC147019; AAI47020.1; -; mRNA.
DR EMBL; BC147027; AAI47028.1; -; mRNA.
DR CCDS; CCDS47087.1; -. [B9EJG8-1]
DR RefSeq; NP_001073975.1; NM_001080506.1. [B9EJG8-1]
DR AlphaFoldDB; B9EJG8; -.
DR BioGRID; 137095; 1.
DR STRING; 9606.ENSP00000420919; -.
DR TCDB; 8.A.113.1.1; the tentonin or tmem150 (tmem150) family.
DR iPTMnet; B9EJG8; -.
DR PhosphoSitePlus; B9EJG8; -.
DR BioMuta; TMEM150C; -.
DR MassIVE; B9EJG8; -.
DR PaxDb; B9EJG8; -.
DR PeptideAtlas; B9EJG8; -.
DR PRIDE; B9EJG8; -.
DR ProteomicsDB; 7533; -. [B9EJG8-1]
DR ProteomicsDB; 7534; -. [B9EJG8-2]
DR Antibodypedia; 58904; 15 antibodies from 8 providers.
DR DNASU; 441027; -.
DR Ensembl; ENST00000449862.7; ENSP00000403438.2; ENSG00000249242.8. [B9EJG8-1]
DR Ensembl; ENST00000515780.6; ENSP00000420919.1; ENSG00000249242.8. [B9EJG8-1]
DR GeneID; 441027; -.
DR KEGG; hsa:441027; -.
DR MANE-Select; ENST00000449862.7; ENSP00000403438.2; NM_001080506.3; NP_001073975.1.
DR UCSC; uc003hmy.2; human. [B9EJG8-1]
DR CTD; 441027; -.
DR GeneCards; TMEM150C; -.
DR HGNC; HGNC:37263; TMEM150C.
DR HPA; ENSG00000249242; Tissue enhanced (epididymis).
DR neXtProt; NX_B9EJG8; -.
DR OpenTargets; ENSG00000249242; -.
DR PharmGKB; PA165664735; -.
DR VEuPathDB; HostDB:ENSG00000249242; -.
DR eggNOG; KOG4320; Eukaryota.
DR GeneTree; ENSGT01030000234578; -.
DR HOGENOM; CLU_059992_0_1_1; -.
DR InParanoid; B9EJG8; -.
DR OMA; ILMAQDI; -.
DR OrthoDB; 1199230at2759; -.
DR PhylomeDB; B9EJG8; -.
DR TreeFam; TF314508; -.
DR PathwayCommons; B9EJG8; -.
DR BioGRID-ORCS; 441027; 14 hits in 1066 CRISPR screens.
DR ChiTaRS; TMEM150C; human.
DR GenomeRNAi; 441027; -.
DR Pharos; B9EJG8; Tdark.
DR PRO; PR:B9EJG8; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; B9EJG8; protein.
DR Bgee; ENSG00000249242; Expressed in corpus epididymis and 193 other tissues.
DR ExpressionAtlas; B9EJG8; baseline and differential.
DR Genevisible; B9EJG8; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005765; C:lysosomal membrane; TAS:UniProtKB.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
DR GO; GO:0019230; P:proprioception; ISS:UniProtKB.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR Pfam; PF10277; Frag1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Lysosome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..249
FT /note="Transmembrane protein 150C"
FT /id="PRO_0000395032"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..64
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..130
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..192
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q86TG1"
FT VAR_SEQ 142..210
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039350"
FT CONFLICT 46
FT /note="K -> R (in Ref. 1; BAH13412)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="I -> V (in Ref. 1; BAH13178)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27887 MW; A4729E0B10C954B4 CRC64;
MDGKKCSVWM FLPLVFTLFT SAGLWIVYFI AVEDDKILPL NSAERKPGVK HAPYISIAGD
DPPASCVFSQ VMNMAAFLAL VVAVLRFIQL KPKVLNPWLN ISGLVALCLA SFGMTLLGNF
QLTNDEEIHN VGTSLTFGFG TLTCWIQAAL TLKVNIKNEG RRVGIPRVIL SASITLCVVL
YFILMAQSIH MYAARVQWGL VMCFLSYFGT FAVEFRHYRY EIVCSEYQEN FLSFSESLSE
ASEYQTDQV
