ID   T150C_RAT               Reviewed;         249 AA.
AC   B5DFH9;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 150C;
GN   Name=Tmem150c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of a mechanosensitive cation channel. Confers
CC       mechanically activated (MA) currents with slow inactivation kinetics.
CC       May contribute to proprioception. {ECO:0000250|UniProtKB:Q8C8S3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B9EJG8};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:B9EJG8}. Lysosome
CC       membrane {ECO:0000250|UniProtKB:B9EJG8}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:B9EJG8}. Note=Localizes at the plasma membrane.
CC       A portion co-localizes with LAMP1 lysosomal marker.
CC       {ECO:0000250|UniProtKB:B9EJG8}.
CC   -!- MISCELLANEOUS: Tentonin comes from the Greek 'tentono' meaning to
CC       stretch.
CC   -!- SIMILARITY: Belongs to the DRAM/TMEM150 family. {ECO:0000305}.
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DR   EMBL; CH474022; EDL99579.1; -; Genomic_DNA.
DR   EMBL; CH474022; EDL99581.1; -; Genomic_DNA.
DR   EMBL; BC169066; AAI69066.1; -; mRNA.
DR   RefSeq; NP_001101824.1; NM_001108354.2.
DR   RefSeq; XP_006250732.1; XM_006250670.3.
DR   RefSeq; XP_017454771.1; XM_017599282.1.
DR   AlphaFoldDB; B5DFH9; -.
DR   STRING; 10116.ENSRNOP00000003076; -.
DR   PaxDb; B5DFH9; -.
DR   Ensembl; ENSRNOT00000003076; ENSRNOP00000003076; ENSRNOG00000002258.
DR   GeneID; 360916; -.
DR   KEGG; rno:360916; -.
DR   UCSC; RGD:1306105; rat.
DR   CTD; 441027; -.
DR   RGD; 1306105; Tmem150c.
DR   eggNOG; KOG4320; Eukaryota.
DR   GeneTree; ENSGT01030000234578; -.
DR   HOGENOM; CLU_059992_0_1_1; -.
DR   InParanoid; B5DFH9; -.
DR   OMA; ILMAQDI; -.
DR   OrthoDB; 1199230at2759; -.
DR   PhylomeDB; B5DFH9; -.
DR   TreeFam; TF314508; -.
DR   PRO; PR:B5DFH9; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Proteomes; UP000234681; Chromosome 14.
DR   Bgee; ENSRNOG00000002258; Expressed in Ammon's horn and 20 other tissues.
DR   Genevisible; B5DFH9; RN.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0008381; F:mechanosensitive ion channel activity; ISO:RGD.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
DR   GO; GO:0019230; P:proprioception; ISS:UniProtKB.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   Pfam; PF10277; Frag1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..249
FT                   /note="Transmembrane protein 150C"
FT                   /id="PRO_0000395034"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..64
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..97
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..130
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..168
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..249
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q86TG1"
SQ   SEQUENCE   249 AA;  27815 MW;  3EB7CEBDAAF5AEFF CRC64;
     MDGKKCSVWM FLPLVFTLFT SAGLWIVYFI AVEDDKILPL NSAARKSGVK HAPYISFAGD
     DPPASCVFSQ VMNMAAFLAL VVAVLRFIQL KPKVLNPWLN ISGLVALCLA SFGMTLLGNF
     QLTNDEEIHN VGTSLTFGFG TLTCWIQAAL TLKVNIKNEG RRAGIPRVIL SAVITLCVVL
     YFILMAQDIH MYAARVQWGL VMCFLAYFGT LAVEFRHYRY EIVCSEYQEN FLSFSESLSE
     ASEYQTDQV