ID   T151A_HUMAN             Reviewed;         468 AA.
AC   Q8N4L1; Q8ND14;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Transmembrane protein 151A;
GN   Name=TMEM151A; Synonyms=TMEM151;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-468.
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- INTERACTION:
CC       Q8N4L1; P46934: NEDD4; NbExp=2; IntAct=EBI-25600031, EBI-726944;
CC       Q8N4L1; P46937: YAP1; NbExp=2; IntAct=EBI-25600031, EBI-1044059;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM151 family. {ECO:0000305}.
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DR   EMBL; BC033898; AAH33898.1; -; mRNA.
DR   EMBL; AL834459; CAD39119.1; -; mRNA.
DR   CCDS; CCDS8133.1; -.
DR   RefSeq; NP_694998.1; NM_153266.3.
DR   AlphaFoldDB; Q8N4L1; -.
DR   BioGRID; 129169; 1.
DR   IntAct; Q8N4L1; 3.
DR   STRING; 9606.ENSP00000326244; -.
DR   iPTMnet; Q8N4L1; -.
DR   PhosphoSitePlus; Q8N4L1; -.
DR   BioMuta; TMEM151A; -.
DR   DMDM; 74728867; -.
DR   jPOST; Q8N4L1; -.
DR   MassIVE; Q8N4L1; -.
DR   PaxDb; Q8N4L1; -.
DR   PeptideAtlas; Q8N4L1; -.
DR   PRIDE; Q8N4L1; -.
DR   ProteomicsDB; 71938; -.
DR   Antibodypedia; 52254; 20 antibodies from 11 providers.
DR   DNASU; 256472; -.
DR   Ensembl; ENST00000327259.5; ENSP00000326244.4; ENSG00000179292.5.
DR   GeneID; 256472; -.
DR   KEGG; hsa:256472; -.
DR   MANE-Select; ENST00000327259.5; ENSP00000326244.4; NM_153266.4; NP_694998.1.
DR   UCSC; uc001ohl.4; human.
DR   CTD; 256472; -.
DR   DisGeNET; 256472; -.
DR   GeneCards; TMEM151A; -.
DR   HGNC; HGNC:28497; TMEM151A.
DR   HPA; ENSG00000179292; Tissue enriched (brain).
DR   neXtProt; NX_Q8N4L1; -.
DR   OpenTargets; ENSG00000179292; -.
DR   PharmGKB; PA162405898; -.
DR   VEuPathDB; HostDB:ENSG00000179292; -.
DR   eggNOG; ENOG502QSYQ; Eukaryota.
DR   GeneTree; ENSGT00390000013762; -.
DR   HOGENOM; CLU_023650_2_0_1; -.
DR   InParanoid; Q8N4L1; -.
DR   OMA; IHSCGAV; -.
DR   OrthoDB; 542596at2759; -.
DR   PhylomeDB; Q8N4L1; -.
DR   TreeFam; TF315223; -.
DR   PathwayCommons; Q8N4L1; -.
DR   SignaLink; Q8N4L1; -.
DR   BioGRID-ORCS; 256472; 23 hits in 1061 CRISPR screens.
DR   GenomeRNAi; 256472; -.
DR   Pharos; Q8N4L1; Tdark.
DR   PRO; PR:Q8N4L1; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8N4L1; protein.
DR   Bgee; ENSG00000179292; Expressed in C1 segment of cervical spinal cord and 100 other tissues.
DR   Genevisible; Q8N4L1; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026767; Tmem151.
DR   PANTHER; PTHR31893; PTHR31893; 1.
DR   Pfam; PF14857; TMEM151; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..468
FT                   /note="Transmembrane protein 151A"
FT                   /id="PRO_0000282986"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   468 AA;  51278 MW;  11CE5306819B222B CRC64;
     MPEDGAGDGG EVPALIPDGE PLREEQRPLK QSLGSSLCRE SHWKCLLLTL LIHACGAVVA
     WCRLATVPRL VLGPEAALAR GAGGPPPTYP ASPCSDGYLY IPLAFVSLLY LLYLAECWHC
     HVRSCQAPRT DAHTVLALIR RLQQAPPCVW WKATSYHYVR RTRQITRYRN GDAYTTTQVY
     HERADSRTAR GEFDYSAHGV RDVSKELVGL AEHAATRLRF TKCFSFGSAE AEASYLTQRA
     RFFSANEGLD DYLEAREGMH LKDVDFRESL MVFADPRSPP WYARAWVFWL VSAATLSWPL
     RVVAAYGTAH VHYQVEKLFG ASSPPPGAVP SGPPLSRVAT VDFTELEWHI CSNRQLVPSY
     SEAVVMGAGS GAYLRGCQRC RRSVSSNSLP PARPSGPRLP FSRSRLSLGA GGRATPGVFR
     SLSGGPLGRR GEDTEPLESP PCYEDALYFP VLIVHGDSGC QGDGQGAL