ID   T151A_MOUSE             Reviewed;         468 AA.
AC   Q6GQT5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Transmembrane protein 151A;
GN   Name=Tmem151a; Synonyms=Gm961, Tmem151;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Medulla oblongata;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 404-413, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM151 family. {ECO:0000305}.
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DR   EMBL; AK163651; BAE37438.1; -; mRNA.
DR   EMBL; BC072634; AAH72634.1; -; mRNA.
DR   CCDS; CCDS29449.1; -.
DR   RefSeq; NP_001001885.1; NM_001001885.1.
DR   AlphaFoldDB; Q6GQT5; -.
DR   STRING; 10090.ENSMUSP00000076321; -.
DR   iPTMnet; Q6GQT5; -.
DR   PhosphoSitePlus; Q6GQT5; -.
DR   SwissPalm; Q6GQT5; -.
DR   PaxDb; Q6GQT5; -.
DR   PeptideAtlas; Q6GQT5; -.
DR   PRIDE; Q6GQT5; -.
DR   ProteomicsDB; 254523; -.
DR   Antibodypedia; 52254; 20 antibodies from 11 providers.
DR   DNASU; 381199; -.
DR   Ensembl; ENSMUST00000077066; ENSMUSP00000076321; ENSMUSG00000061451.
DR   GeneID; 381199; -.
DR   KEGG; mmu:381199; -.
DR   UCSC; uc008gcc.1; mouse.
DR   CTD; 256472; -.
DR   MGI; MGI:2147713; Tmem151a.
DR   VEuPathDB; HostDB:ENSMUSG00000061451; -.
DR   eggNOG; ENOG502QSYQ; Eukaryota.
DR   GeneTree; ENSGT00390000013762; -.
DR   HOGENOM; CLU_023650_2_0_1; -.
DR   InParanoid; Q6GQT5; -.
DR   OMA; IHSCGAV; -.
DR   OrthoDB; 542596at2759; -.
DR   PhylomeDB; Q6GQT5; -.
DR   TreeFam; TF315223; -.
DR   BioGRID-ORCS; 381199; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Tmem151a; mouse.
DR   PRO; PR:Q6GQT5; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q6GQT5; protein.
DR   Bgee; ENSMUSG00000061451; Expressed in primary visual cortex and 128 other tissues.
DR   ExpressionAtlas; Q6GQT5; baseline and differential.
DR   Genevisible; Q6GQT5; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026767; Tmem151.
DR   PANTHER; PTHR31893; PTHR31893; 1.
DR   Pfam; PF14857; TMEM151; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..468
FT                   /note="Transmembrane protein 151A"
FT                   /id="PRO_0000282987"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   468 AA;  51312 MW;  0067ED7B07FAAF65 CRC64;
     MPEGEGGDCG EVPALVPDGE PLREEQRPLK QSLGGSLCRE SHWKCLLLTL LIHACGAVVA
     WCRLATVPRL VLGPEAALAR GAGGPPPTYP ASPCSDGYLY IPLAFVSLLY LLYLAECWHC
     HVRSCQAPRT DANTVLALIH RLQQAPPCVW WKATSYHYVR RTRQITRYRN GDAYTTTQVY
     HERADSRTAR GEFDYSAHGV RDVSKELVGL ADHAATRLRF TKCFSFGSAE AEASYLTQRA
     RFFSANEGLD DYLEAREGMH LKDVDFRESL MVFADPRSPP WYARAWVFWL VSAATLSWPL
     RVVAAYGTAH VHYQVEKLFG ASSPPPGAVP SGPPLSRVAT VDFTELEWHI CSNRQLVPSY
     SEAVVMGASS GAYLRGCQRC RRSVSSNSLP PARPSGPRLP FSRSRLSLGA GGRTTPGVFR
     SLSGGPLGRR GEDTEPLESP PCYEDALYFP VLIVHGDSGC RGDGQGAL