T151B_HUMAN
ID T151B_HUMAN Reviewed; 566 AA.
AC Q8IW70; Q5T9V7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transmembrane protein 151B;
DE AltName: Full=Transmembrane protein 193;
GN Name=TMEM151B; Synonyms=C6orf137, TMEM193;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 22-222 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IW70-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IW70-2; Sequence=VSP_028639, VSP_028640;
CC -!- SIMILARITY: Belongs to the TMEM151 family. {ECO:0000305}.
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DR EMBL; AL139392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC040881; AAH40881.1; -; mRNA.
DR CCDS; CCDS47437.1; -. [Q8IW70-1]
DR RefSeq; NP_001131032.1; NM_001137560.1. [Q8IW70-1]
DR AlphaFoldDB; Q8IW70; -.
DR BioGRID; 137212; 1.
DR IntAct; Q8IW70; 2.
DR STRING; 9606.ENSP00000393161; -.
DR iPTMnet; Q8IW70; -.
DR PhosphoSitePlus; Q8IW70; -.
DR BioMuta; TMEM151B; -.
DR DMDM; 160017491; -.
DR jPOST; Q8IW70; -.
DR MassIVE; Q8IW70; -.
DR PaxDb; Q8IW70; -.
DR PeptideAtlas; Q8IW70; -.
DR PRIDE; Q8IW70; -.
DR ProteomicsDB; 70819; -. [Q8IW70-1]
DR Antibodypedia; 65189; 71 antibodies from 15 providers.
DR DNASU; 441151; -.
DR Ensembl; ENST00000438774.2; ENSP00000409337.2; ENSG00000178233.18. [Q8IW70-2]
DR Ensembl; ENST00000451188.7; ENSP00000393161.2; ENSG00000178233.18. [Q8IW70-1]
DR GeneID; 441151; -.
DR KEGG; hsa:441151; -.
DR MANE-Select; ENST00000451188.7; ENSP00000393161.2; NM_001137560.2; NP_001131032.1.
DR UCSC; uc003oxf.3; human. [Q8IW70-1]
DR CTD; 441151; -.
DR DisGeNET; 441151; -.
DR GeneCards; TMEM151B; -.
DR HGNC; HGNC:21315; TMEM151B.
DR HPA; ENSG00000178233; Tissue enriched (brain).
DR neXtProt; NX_Q8IW70; -.
DR OpenTargets; ENSG00000178233; -.
DR PharmGKB; PA162405899; -.
DR VEuPathDB; HostDB:ENSG00000178233; -.
DR eggNOG; ENOG502QSYQ; Eukaryota.
DR GeneTree; ENSGT00390000013762; -.
DR HOGENOM; CLU_023650_2_0_1; -.
DR InParanoid; Q8IW70; -.
DR OMA; CRHIPRV; -.
DR OrthoDB; 542596at2759; -.
DR PhylomeDB; Q8IW70; -.
DR TreeFam; TF315223; -.
DR PathwayCommons; Q8IW70; -.
DR BioGRID-ORCS; 441151; 13 hits in 1074 CRISPR screens.
DR ChiTaRS; TMEM151B; human.
DR GenomeRNAi; 441151; -.
DR Pharos; Q8IW70; Tdark.
DR PRO; PR:Q8IW70; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8IW70; protein.
DR Bgee; ENSG00000178233; Expressed in paraflocculus and 150 other tissues.
DR Genevisible; Q8IW70; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026767; Tmem151.
DR PANTHER; PTHR31893; PTHR31893; 1.
DR Pfam; PF14857; TMEM151; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..566
FT /note="Transmembrane protein 151B"
FT /id="PRO_0000307220"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 194..222
FT /note="YHERVNTHVAEAEFDYARCGVRDVSKTLV -> PGCLGSQVVPLRSPWRNAQ
FT LDAGSDEEPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028639"
FT VAR_SEQ 223..566
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028640"
SQ SEQUENCE 566 AA; 61506 MW; 0E55F9D545DC5022 CRC64;
MSPPGSAAGE SAAGGGGGGG GPGVSEELTA AAAAAAADEG PAREEQRPIQ PSFTKSLCRE
SHWKCLLLSL LMYGCLGAVA WCHVTTVTRL TFSSAYQGNS LMYHDSPCSN GYVYIPLAFL
LMLYAVYLVE CWHCQARHEL QHRVDVSSVR ERVGRMQQAT PCIWWKAISY HYVRRTRQVT
RYRNGDAYTT TQVYHERVNT HVAEAEFDYA RCGVRDVSKT LVGLEGAPAT RLRFTKCFSF
ASVEAENAYL CQRARFFAEN EGLDDYMEAR EGMHLKNVDF REFMVAFPDP ARPPWYACSS
AFWAAALLTL SWPLRVLAEY RTAYAHYHVE KLFGLEGPGS ASSAGGGLSP SDELLPPLTH
RLPRVNTVDS TELEWHIRSN QQLVPSYSEA VLMDLAGLGT RCGGAGGGYA PSCRYGGVGG
PGAAGVAPYR RSCEHCQRAV SSSSIFSRSA LSICASPRAG PGPGGGAGCG GSRFSLGRLY
GSRRSCLWRS RSGSVNEASC PTEQTRLSSQ ASMGDDEDDD EEEAGPPPPY HDALYFPVLI
VHRQEGCLGH SHRPLHRHGS CVETSL
