T161A_DANRE
ID T161A_DANRE Reviewed; 495 AA.
AC Q0V947; Q1LVH8; Q567V8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Transmembrane protein 161A;
DE Flags: Precursor;
GN Name=tmem161a; ORFNames=im:7149790, si:dkey-11n6.2, zgc:152766;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in protection against oxidative stress.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM161 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAK05125.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BX664610; CAK05125.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC121758; AAI21759.1; -; mRNA.
DR RefSeq; NP_001037782.1; NM_001044317.1.
DR AlphaFoldDB; Q0V947; -.
DR STRING; 7955.ENSDARP00000007148; -.
DR PaxDb; Q0V947; -.
DR Ensembl; ENSDART00000083879; ENSDARP00000078314; ENSDARG00000012790.
DR GeneID; 492692; -.
DR KEGG; dre:492692; -.
DR CTD; 54929; -.
DR ZFIN; ZDB-GENE-041111-267; tmem161a.
DR eggNOG; KOG3978; Eukaryota.
DR GeneTree; ENSGT00390000000672; -.
DR HOGENOM; CLU_027277_0_0_1; -.
DR InParanoid; Q0V947; -.
DR OrthoDB; 734854at2759; -.
DR PhylomeDB; Q0V947; -.
DR PRO; PR:Q0V947; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000012790; Expressed in mature ovarian follicle and 29 other tissues.
DR ExpressionAtlas; Q0V947; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019395; Transmembrane_161A/B.
DR PANTHER; PTHR13624; PTHR13624; 1.
DR Pfam; PF10268; Tmemb_161AB; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..495
FT /note="Transmembrane protein 161A"
FT /id="PRO_0000288086"
FT TOPO_DOM 29..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..167
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..367
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..465
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 487..495
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 325
FT /note="V -> F (in Ref. 2; AAI21759)"
FT /evidence="ECO:0000305"
FT CONFLICT 411
FT /note="T -> S (in Ref. 2; AAI21759)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 55650 MW; 2F84AC4ECC6C8D56 CRC64;
MALMGVQLVV SLLAVSIMQR MAPHLSFARW LLCNGSLLKF RHPSEGELCA LAGKQIPKTS
RRDRRQNGHG ESKPLTVPKD IDLHLESTPV NVMDALVLRF FVEYQWLIDF AVYATGIYLF
TEGYYSVVDA SKEVNIASIW CVLTVLFCLR TLYLLMSHYF LSEEGGERSV CLAFGFLSLL
IAMLVLVVRE DYLEFGLEPG FTSLFDNFEV FARKQGYEWS VPFTKLSVKL GLAVICAFIG
ALLAFPGLRL AQTHLDAVQM NADRPMIQIL LHMSFLSPLV IIVMWIKPIA RDFLGNAPMG
KTSVTLLSSS AFSSVRLWTI VVLCVLRLLL TRYHLQAYLN LAQKWVEQMK KEAGRIAAID
IQRKVTRIFC YLTVVTLQYL IPILLVLFST LALKSLGDFS WGLGAETPGV TPAPIIPSST
PPPVPGPEDD EDMEDMEEDI QATVAHLTEL FSALRALLTP IFFRGIFAFL TWWVAACQLI
SSLFGIYFHQ YLMHN
