ID   T161A_XENLA             Reviewed;         489 AA.
AC   Q6GMB1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Transmembrane protein 161A;
DE   Flags: Precursor;
GN   Name=tmem161a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in protection against oxidative stress.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM161 family. {ECO:0000305}.
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DR   EMBL; BC074159; AAH74159.1; -; mRNA.
DR   RefSeq; NP_001086075.1; NM_001092606.1.
DR   AlphaFoldDB; Q6GMB1; -.
DR   DNASU; 444504; -.
DR   GeneID; 444504; -.
DR   KEGG; xla:444504; -.
DR   CTD; 444504; -.
DR   Xenbase; XB-GENE-6254899; tmem161a.L.
DR   OrthoDB; 734854at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 444504; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019395; Transmembrane_161A/B.
DR   PANTHER; PTHR13624; PTHR13624; 1.
DR   Pfam; PF10268; Tmemb_161AB; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..489
FT                   /note="Transmembrane protein 161A"
FT                   /id="PRO_0000288087"
FT   TOPO_DOM        24..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..166
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..304
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..370
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        392..459
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        481..489
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          413..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   489 AA;  56194 MW;  CC6989FDAC24C491 CRC64;
     MAVMGIQMVV TLLVASLMQR VSPHYSFGRW LLCNGSLFRY KHPTEEELRT LAGKQKPKAK
     KERRTNGVAE EKPLTVPKDI DLRLDTQPIN TMDALVLRYF LEYQWFIDFA LYSTIIYLFT
     EAYYCVVDAQ NEINIGVLWC LMSIIFSIKV LFTVMKHYFR SEEGGERSVC MTFAFFFLLI
     AMIVTIVRDE YLEFGLEPGL ASVCHNLENF LAQQGWQWSM PFVKLAFKIA LVALCAFLGG
     CLTFPGLRLA QTHLDALKMA ADRPMLQLLL HMSFLPPVIV VVLWIRPITR DFLLNAPMGK
     ESVELMSNSA YNTFRLWIIV LLCLLRFCLT RFHLQAYLCL ADRWVEQMKR EAGRISMLEI
     QRKISRIFCY LTVVALQYLA PVILTFHCVF MLKSLGDYSW GLYPEPPGFS PVVDSSPVQS
     HSPTSEEEED TEDVQAAVEQ IMGVLTSLRG LFTPLFFRGI FSFLTWWVSV CQIITSLFGL
     YFHQYLGAS