ID   T161A_XENTR             Reviewed;         489 AA.
AC   Q28FG4; Q6NVP1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Transmembrane protein 161A;
DE   Flags: Precursor;
GN   Name=tmem161; ORFNames=TEgg031b04.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in protection against oxidative stress.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28FG4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28FG4-2; Sequence=VSP_025646;
CC   -!- SIMILARITY: Belongs to the TMEM161 family. {ECO:0000305}.
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DR   EMBL; CR761984; CAJ81447.1; -; mRNA.
DR   EMBL; BC067964; AAH67964.1; -; mRNA.
DR   RefSeq; NP_001001896.2; NM_001001896.2. [Q28FG4-1]
DR   AlphaFoldDB; Q28FG4; -.
DR   STRING; 8364.ENSXETP00000031352; -.
DR   PaxDb; Q28FG4; -.
DR   DNASU; 431674; -.
DR   Ensembl; ENSXETT00000031352; ENSXETP00000031352; ENSXETG00000014335.
DR   GeneID; 431674; -.
DR   KEGG; xtr:431674; -.
DR   CTD; 54929; -.
DR   Xenbase; XB-GENE-1004051; tmem161a.
DR   eggNOG; KOG3978; Eukaryota.
DR   HOGENOM; CLU_027277_0_0_1; -.
DR   InParanoid; Q28FG4; -.
DR   OMA; VCAYIGS; -.
DR   OrthoDB; 734854at2759; -.
DR   PhylomeDB; Q28FG4; -.
DR   TreeFam; TF314570; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014335; Expressed in ovary and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR019395; Transmembrane_161A/B.
DR   PANTHER; PTHR13624; PTHR13624; 1.
DR   Pfam; PF10268; Tmemb_161AB; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..489
FT                   /note="Transmembrane protein 161A"
FT                   /id="PRO_0000288088"
FT   TOPO_DOM        24..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        156..166
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..224
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        246..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..304
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..366
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        388..459
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        460..480
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        481..489
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          51..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          413..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         96..198
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_025646"
SQ   SEQUENCE   489 AA;  56149 MW;  16264B69BF1332DA CRC64;
     MAIMGVQMVV TLLVASIMQR VSPHYSFGRW LLCNGSLFRF KHPTEEELRT LAGKQKPKAK
     RERRTNGVTD EKPLTVPKDI DLRLDTQPIT TIDALVLRYF LEYQWFIDFA LYSTIIYLFT
     EAYYCVVDAQ NEINIGVLWC LMSIIFSIKV LFTVMKHYFR SEEGGERSVC LTFAFFFLLI
     AMIVMVVRDE YLEFGLEPGL ASVCHNLENF LAQRGWQWSM PFVKLAFKIA LVALCAFLGG
     CLTFPGLRLA QTHLDALKMA ADRPMLQLLL HMSFLPPVIV VVLWIRPITR DFLLNAPMGK
     ESVELMSNSA YNTFRLWIIV VLCLLRFCLT RFHLQAYLCL ADRWVEQMKR EAGRISMLEI
     QRKISRIFCY LTVVALQYLA PIVLTFHCVL MLKSLGDYSW GLYPEPTGFT PVVDSSPVQS
     HSPTSEEEED TEDVQAAVEQ IMGAMSSLRG LFTPLFFRGL FSFLTWWVSV CQIVTSLFGL
     YFHQYLGAS