T161B_HUMAN
ID T161B_HUMAN Reviewed; 487 AA.
AC Q8NDZ6; Q5CZH7; Q6UWQ6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transmembrane protein 161B;
GN Name=TMEM161B; ORFNames=UNQ679/PRO1313;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Essential for maintaining normal cardiac rhythm in the
CC developing heart and for neonatal survival (By similarity). Inhibits
CC potassium and calcium currents in the cardiomyocytes, this assists in
CC timely action potential repolarization and thereby maintains normal
CC cardiac rhythm (By similarity). {ECO:0000250|UniProtKB:Q8C2L6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7SY10};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NDZ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDZ6-2; Sequence=VSP_025649, VSP_025650;
CC Name=3;
CC IsoId=Q8NDZ6-3; Sequence=VSP_025647, VSP_025648;
CC -!- SIMILARITY: Belongs to the TMEM161 family. {ECO:0000305}.
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DR EMBL; AY358693; AAQ89056.1; -; mRNA.
DR EMBL; BX648757; CAI56713.1; -; mRNA.
DR EMBL; BC037287; AAH37287.1; -; mRNA.
DR CCDS; CCDS4065.1; -. [Q8NDZ6-1]
DR RefSeq; NP_699185.1; NM_153354.4. [Q8NDZ6-1]
DR AlphaFoldDB; Q8NDZ6; -.
DR BioGRID; 127493; 65.
DR IntAct; Q8NDZ6; 6.
DR STRING; 9606.ENSP00000426354; -.
DR GlyGen; Q8NDZ6; 3 sites.
DR iPTMnet; Q8NDZ6; -.
DR PhosphoSitePlus; Q8NDZ6; -.
DR BioMuta; TMEM161B; -.
DR DMDM; 74730190; -.
DR EPD; Q8NDZ6; -.
DR jPOST; Q8NDZ6; -.
DR MassIVE; Q8NDZ6; -.
DR MaxQB; Q8NDZ6; -.
DR PaxDb; Q8NDZ6; -.
DR PeptideAtlas; Q8NDZ6; -.
DR PRIDE; Q8NDZ6; -.
DR ProteomicsDB; 73102; -. [Q8NDZ6-1]
DR ProteomicsDB; 73103; -. [Q8NDZ6-2]
DR ProteomicsDB; 73104; -. [Q8NDZ6-3]
DR Antibodypedia; 50472; 75 antibodies from 15 providers.
DR DNASU; 153396; -.
DR Ensembl; ENST00000296595.11; ENSP00000296595.6; ENSG00000164180.14. [Q8NDZ6-1]
DR Ensembl; ENST00000510089.5; ENSP00000423380.1; ENSG00000164180.14. [Q8NDZ6-3]
DR GeneID; 153396; -.
DR KEGG; hsa:153396; -.
DR MANE-Select; ENST00000296595.11; ENSP00000296595.6; NM_153354.5; NP_699185.1.
DR UCSC; uc003kjc.5; human. [Q8NDZ6-1]
DR CTD; 153396; -.
DR DisGeNET; 153396; -.
DR GeneCards; TMEM161B; -.
DR HGNC; HGNC:28483; TMEM161B.
DR HPA; ENSG00000164180; Low tissue specificity.
DR neXtProt; NX_Q8NDZ6; -.
DR OpenTargets; ENSG00000164180; -.
DR PharmGKB; PA145147987; -.
DR VEuPathDB; HostDB:ENSG00000164180; -.
DR eggNOG; KOG0017; Eukaryota.
DR eggNOG; KOG3978; Eukaryota.
DR GeneTree; ENSGT00390000000672; -.
DR HOGENOM; CLU_027277_0_0_1; -.
DR InParanoid; Q8NDZ6; -.
DR OMA; RFALMPI; -.
DR OrthoDB; 734854at2759; -.
DR PhylomeDB; Q8NDZ6; -.
DR TreeFam; TF314570; -.
DR PathwayCommons; Q8NDZ6; -.
DR SignaLink; Q8NDZ6; -.
DR BioGRID-ORCS; 153396; 18 hits in 1076 CRISPR screens.
DR ChiTaRS; TMEM161B; human.
DR GenomeRNAi; 153396; -.
DR Pharos; Q8NDZ6; Tbio.
DR PRO; PR:Q8NDZ6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8NDZ6; protein.
DR Bgee; ENSG00000164180; Expressed in epithelial cell of pancreas and 178 other tissues.
DR ExpressionAtlas; Q8NDZ6; baseline and differential.
DR Genevisible; Q8NDZ6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0098901; P:regulation of cardiac muscle cell action potential; ISS:UniProtKB.
DR GO; GO:0002027; P:regulation of heart rate; ISS:UniProtKB.
DR InterPro; IPR019395; Transmembrane_161A/B.
DR PANTHER; PTHR13624; PTHR13624; 1.
DR Pfam; PF10268; Tmemb_161AB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..487
FT /note="Transmembrane protein 161B"
FT /id="PRO_0000288089"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..127
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_025647"
FT VAR_SEQ 268..487
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_025648"
FT VAR_SEQ 302..307
FT /note="SIPLMT -> ISPSGR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_025649"
FT VAR_SEQ 308..487
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_025650"
SQ SEQUENCE 487 AA; 55482 MW; 18A1D716F7F87369 CRC64;
MGVIGIQLVV TMVMASVMQK IIPHYSLARW LLCNGSLRWY QHPTEEELRI LAGKQQKGKT
KKDRKYNGHI ESKPLTIPKD IDLHLETKSV TEVDTLALHY FPEYQWLVDF TVAATVVYLV
TEVYYNFMKP TQEMNISLVW CLLVLSFAIK VLFSLTTHYF KVEDGGERSV CVTFGFFFFV
KAMAVLIVTE NYLEFGLETG FTNFSDSAMQ FLEKQGLESQ SPVSKLTFKF FLAIFCSFIG
AFLTFPGLRL AQMHLDALNL ATEKITQTLL HINFLAPLFM VLLWVKPITK DYIMNPPLGK
ESIPLMTEAT FDTLRLWLII LLCALRLAMM RSHLQAYLNL AQKCVDQMKK EAGRISTVEL
QKMVARVFYY LCVIALQYVA PLVMLLHTTL LLKTLGNHSW GIYPESISTL PVDNSLLSNS
VYSELPSAEG KMKVTVTQIT VALSSLKNIF TPLLFRGLLS FLTWWIAACL FSTSLFGLFY
HQYLTVA
