T168A_DANRE
ID T168A_DANRE Reviewed; 681 AA.
AC Q1LUD1;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Transmembrane protein 168-A;
GN Name=tmem168a; ORFNames=si:dkey-192l17.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM168 family. {ECO:0000305}.
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DR EMBL; BX950217; CAK05342.1; -; Genomic_DNA.
DR RefSeq; NP_001076555.1; NM_001083086.1.
DR RefSeq; XP_005165052.1; XM_005164995.3.
DR AlphaFoldDB; Q1LUD1; -.
DR STRING; 7955.ENSDARP00000125427; -.
DR PaxDb; Q1LUD1; -.
DR Ensembl; ENSDART00000150389; ENSDARP00000125427; ENSDARG00000068705.
DR Ensembl; ENSDART00000184175; ENSDARP00000153111; ENSDARG00000068705.
DR GeneID; 100034546; -.
DR KEGG; dre:100034546; -.
DR CTD; 100034546; -.
DR ZFIN; ZDB-GENE-050419-97; tmem168a.
DR eggNOG; ENOG502QRB6; Eukaryota.
DR GeneTree; ENSGT00390000005941; -.
DR HOGENOM; CLU_032315_0_0_1; -.
DR InParanoid; Q1LUD1; -.
DR OMA; SMGKVWR; -.
DR OrthoDB; 619817at2759; -.
DR PhylomeDB; Q1LUD1; -.
DR TreeFam; TF328518; -.
DR PRO; PR:Q1LUD1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000068705; Expressed in mature ovarian follicle and 20 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029713; TMEM168.
DR PANTHER; PTHR14437; PTHR14437; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..681
FT /note="Transmembrane protein 168-A"
FT /id="PRO_0000284634"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 681 AA; 76577 MW; D97970144B20E488 CRC64;
MSGQEKSDKS VDMWSFLRCL GYLSSFNLLV AVCLGMYVRW EQTSEPMILV LFILGLFVSA
IACILYYYFS MESASLSLFH LWFGFLQGLL CFLNSPSLED EIKEQVTNYL LLSSVSIRTL
WALTERLCAN PKYKPVVITS SELLELLGFG VASISLVFDK SLAMIALTFA LTALIIDLRM
KSPLALPNLA CFSVIAAVTF FQSLKIQTNP FALSCYLGRL ICEPLLDVYF SSLTATERWK
QFLSAGRLWR RFSLFPLALV ELLFFVVCAF KLGNLKDWYL VIPGFCIFGL LWILCHMVFL
VTLWCFHTKL SECQKMWAAQ RLQTLNLDRI MASRGMRHFC LISERLVLFC LMSTIILGAV
SWQVANGLFM SVFLVVLPLE SLAHGLFHEL GNGLGGTCVG YAVVIPTCYS SADGQPVLLP
PGQVQELHST STLNAVQRLF SHHLIQTFGC DYSTSLSLET LLVKLRSFLE LCTAEGPRHD
TYILYYSGHT LPSGDWTLAG GDYLRMKQIL DMWREQNSSF SSRLILVLDT ENSAPWVKAV
RKVEGMYVAV QGAKLSPVQD AEGQDAPRLG DFTSEWVKYN CDPESGVQWS ERGRVISAIY
GVSKPWSDYA LHLPTGSDVA KHWKTHFPKT TYPLVAVANW CCGLNLLWLC SVCLRCVRRL
KLSWFPPSIL DTGQGIKLVR S
