T170A_CHICK
ID T170A_CHICK Reviewed; 138 AA.
AC Q5ZM31; Q5ZM01;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Transmembrane protein 170A;
GN Name=TMEM170A; Synonyms=TMEM170; ORFNames=RCJMB04_3f9, RCJMB04_4c23;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: May regulate membrane morphogenesis in the endoplasmic
CC reticulum (ER) by promoting ER sheet formation at the expense of ER
CC tubules. {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8WVE7}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG31242.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ719553; CAG31212.1; -; mRNA.
DR EMBL; AJ719583; CAG31242.1; ALT_INIT; mRNA.
DR RefSeq; NP_001074349.1; NM_001080880.1.
DR AlphaFoldDB; Q5ZM31; -.
DR STRING; 9031.ENSGALP00000004506; -.
DR PaxDb; Q5ZM31; -.
DR GeneID; 770531; -.
DR KEGG; gga:770531; -.
DR CTD; 124491; -.
DR VEuPathDB; HostDB:geneid_770531; -.
DR eggNOG; KOG4349; Eukaryota.
DR InParanoid; Q5ZM31; -.
DR OrthoDB; 1545489at2759; -.
DR PhylomeDB; Q5ZM31; -.
DR PRO; PR:Q5ZM31; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR InterPro; IPR019334; Transmembrane_pr_170.
DR PANTHER; PTHR22779; PTHR22779; 1.
DR Pfam; PF10190; Tmemb_170; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..138
FT /note="Transmembrane protein 170A"
FT /id="PRO_0000291761"
FT TOPO_DOM 1..44
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..110
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 53
FT /note="L -> P (in Ref. 1; CAG31242)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="E -> G (in Ref. 1; CAG31242)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 138 AA; 14791 MW; 042481BC804489BF CRC64;
MEGSEAGGGG LLQQILSLRL VPRVGNGTTY SSPLSTFPEM WYGVFLWALV SSLSFHVPAA
LLALFTLRHH KYGRFMSVSL LLMGIVGPIT AGILTSAAIA GVYRAAGKKM IPFEALIFEV
GQTFCVVVVS FLRILATL
