T170A_DANRE
ID T170A_DANRE Reviewed; 145 AA.
AC A3KPL7; Q6PCR5;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Transmembrane protein 170A;
GN Name=tmem170a; Synonyms=tmem170; ORFNames=si:dkey-6e12.5, zgc:66371;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate membrane morphogenesis in the endoplasmic
CC reticulum (ER) by promoting ER sheet formation at the expense of ER
CC tubules. {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8WVE7}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH59199.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX088593; CAM56720.1; -; Genomic_DNA.
DR EMBL; BC059199; AAH59199.1; ALT_INIT; mRNA.
DR RefSeq; NP_956983.1; NM_200689.1.
DR AlphaFoldDB; A3KPL7; -.
DR STRING; 7955.ENSDARP00000073614; -.
DR PaxDb; A3KPL7; -.
DR Ensembl; ENSDART00000079158; ENSDARP00000073614; ENSDARG00000056628.
DR Ensembl; ENSDART00000191196; ENSDARP00000154851; ENSDARG00000111549.
DR GeneID; 393662; -.
DR KEGG; dre:393662; -.
DR CTD; 124491; -.
DR ZFIN; ZDB-GENE-040426-1622; tmem170a.
DR eggNOG; KOG4349; Eukaryota.
DR GeneTree; ENSGT00940000159189; -.
DR HOGENOM; CLU_149050_1_1_1; -.
DR InParanoid; A3KPL7; -.
DR OMA; AGKTMMS; -.
DR OrthoDB; 1545489at2759; -.
DR PhylomeDB; A3KPL7; -.
DR TreeFam; TF314615; -.
DR PRO; PR:A3KPL7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000056628; Expressed in mature ovarian follicle and 19 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR InterPro; IPR019334; Transmembrane_pr_170.
DR PANTHER; PTHR22779; PTHR22779; 1.
DR Pfam; PF10190; Tmemb_170; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..145
FT /note="Transmembrane protein 170A"
FT /id="PRO_0000291762"
FT TOPO_DOM 1..50
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..117
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 61
FT /note="I -> T (in Ref. 2; AAH59199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 145 AA; 15696 MW; FDC2FC9E3033280C CRC64;
MIEALIVGEM QDVQIGFVKQ ILSLNLVPRS NNTTCGNNTS LCDFSEMWYG VFLWAVVSSL
IFHLPAALLA LATLRRHKVA RFFPLGILLM GIIGPLFGGV LTSAAIAGVY KAAGKSMFSL
EALVFGVGQS LFIFIISFLR ILATL
