T170A_HUMAN
ID T170A_HUMAN Reviewed; 144 AA.
AC Q8WVE7; B2R4R3; B4DPS4; D3DUK2; Q7Z6F3;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Transmembrane protein 170A;
GN Name=TMEM170A; Synonyms=TMEM170;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Zhou G., Yu R., Li H., Shen C., Zhong G., Lin L., Yang S.;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, AND INTERACTION WITH RTN4.
RX PubMed=26906412; DOI=10.1242/jcs.175273;
RA Christodoulou A., Santarella-Mellwig R., Santama N., Mattaj I.W.;
RT "Transmembrane protein TMEM170A is a novel regulator of ER and NE
RT morphogenesis in human cells.";
RL J. Cell Sci. 129:1552-1565(2016).
CC -!- FUNCTION: Acts as a regulator of endoplasmic reticulum (ER) and nuclear
CC envelope (NE) morphogenesis. Affects the ratio between tubular ER and
CC ER sheets by promoting sheet formation at the expense of tubules.
CC Influences NE expansion, nuclear pore complex formation and proper
CC localization of inner nuclear membrane proteins (PubMed:26906412).
CC {ECO:0000269|PubMed:26906412}.
CC -!- SUBUNIT: Interacts with RTN4 (PubMed:26906412).
CC {ECO:0000269|PubMed:26906412}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:26906412}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:26906412}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WVE7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WVE7-2; Sequence=VSP_026229;
CC -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
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DR EMBL; AY302139; AAP57631.1; -; mRNA.
DR EMBL; AK298475; BAG60686.1; -; mRNA.
DR EMBL; AK311919; BAG34860.1; -; mRNA.
DR EMBL; BX648484; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC009163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471114; EAW95643.1; -; Genomic_DNA.
DR EMBL; CH471114; EAW95644.1; -; Genomic_DNA.
DR EMBL; BC018082; AAH18082.1; -; mRNA.
DR CCDS; CCDS10917.1; -. [Q8WVE7-1]
DR CCDS; CCDS76901.1; -. [Q8WVE7-2]
DR RefSeq; NP_001291925.1; NM_001304996.1. [Q8WVE7-2]
DR RefSeq; NP_660297.1; NM_145254.2. [Q8WVE7-1]
DR AlphaFoldDB; Q8WVE7; -.
DR BioGRID; 125868; 13.
DR STRING; 9606.ENSP00000454404; -.
DR TCDB; 8.A.70.1.1; the endomembrane morphogenesis tmem170a (tmem170a) family.
DR GlyGen; Q8WVE7; 2 sites.
DR iPTMnet; Q8WVE7; -.
DR PhosphoSitePlus; Q8WVE7; -.
DR BioMuta; TMEM170A; -.
DR DMDM; 74730840; -.
DR MassIVE; Q8WVE7; -.
DR PaxDb; Q8WVE7; -.
DR PeptideAtlas; Q8WVE7; -.
DR PRIDE; Q8WVE7; -.
DR Antibodypedia; 71565; 4 antibodies from 4 providers.
DR DNASU; 124491; -.
DR Ensembl; ENST00000357613.8; ENSP00000350230.4; ENSG00000166822.13. [Q8WVE7-2]
DR Ensembl; ENST00000561878.2; ENSP00000454404.1; ENSG00000166822.13. [Q8WVE7-1]
DR Ensembl; ENST00000568559.1; ENSP00000454552.1; ENSG00000166822.13. [Q8WVE7-2]
DR GeneID; 124491; -.
DR KEGG; hsa:124491; -.
DR MANE-Select; ENST00000561878.2; ENSP00000454404.1; NM_145254.3; NP_660297.1.
DR UCSC; uc002fec.4; human. [Q8WVE7-1]
DR CTD; 124491; -.
DR DisGeNET; 124491; -.
DR GeneCards; TMEM170A; -.
DR HGNC; HGNC:29577; TMEM170A.
DR HPA; ENSG00000166822; Low tissue specificity.
DR neXtProt; NX_Q8WVE7; -.
DR OpenTargets; ENSG00000166822; -.
DR PharmGKB; PA162405922; -.
DR VEuPathDB; HostDB:ENSG00000166822; -.
DR eggNOG; KOG4349; Eukaryota.
DR GeneTree; ENSGT00940000159189; -.
DR HOGENOM; CLU_149050_1_1_1; -.
DR InParanoid; Q8WVE7; -.
DR OMA; AGKTMMS; -.
DR OrthoDB; 1545489at2759; -.
DR PhylomeDB; Q8WVE7; -.
DR TreeFam; TF314615; -.
DR PathwayCommons; Q8WVE7; -.
DR BioGRID-ORCS; 124491; 13 hits in 1078 CRISPR screens.
DR ChiTaRS; TMEM170A; human.
DR GenomeRNAi; 124491; -.
DR Pharos; Q8WVE7; Tdark.
DR PRO; PR:Q8WVE7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8WVE7; protein.
DR Bgee; ENSG00000166822; Expressed in pancreatic ductal cell and 182 other tissues.
DR ExpressionAtlas; Q8WVE7; baseline and differential.
DR Genevisible; Q8WVE7; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:UniProtKB.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; IMP:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; IMP:UniProtKB.
DR GO; GO:0051292; P:nuclear pore complex assembly; IMP:UniProtKB.
DR InterPro; IPR019334; Transmembrane_pr_170.
DR PANTHER; PTHR22779; PTHR22779; 1.
DR Pfam; PF10190; Tmemb_170; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Nucleus; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..144
FT /note="Transmembrane protein 170A"
FT /id="PRO_0000291759"
FT TOPO_DOM 1..50
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:26906412"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:26906412"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..116
FT /note="Lumenal"
FT /evidence="ECO:0000305|PubMed:26906412"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:26906412"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 80..102
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:17974005, ECO:0000303|Ref.1"
FT /id="VSP_026229"
SQ SEQUENCE 144 AA; 15250 MW; C4ABBC85305CDCF0 CRC64;
MEREGSGGSG GSAGLLQQIL SLKVVPRVGN GTLCPNSTSL CSFPEMWYGV FLWALVSSLF
FHVPAGLLAL FTLRHHKYGR FMSVSILLMG IVGPITAGIL TSAAIAGVYR AAGKEMIPFE
ALTLGTGQTF CVLVVSFLRI LATL
