T170A_MOUSE
ID T170A_MOUSE Reviewed; 144 AA.
AC Q9D342; A6H6Q8;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Transmembrane protein 170A;
GN Name=Tmem170a; Synonyms=D8Bwg1414e, Tmem170;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a regulator of endoplasmic reticulum (ER) and nuclear
CC envelope (NE) morphogenesis. Affects the ratio between tubular ER and
CC ER sheets by promoting sheet formation at the expense of tubules.
CC Influences NE expansion, nuclear pore complex formation and proper
CC localization of inner nuclear membrane proteins.
CC {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SUBUNIT: Interacts with RTN4. {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8WVE7}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
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DR EMBL; AK018496; BAB31240.1; -; mRNA.
DR EMBL; BC139377; AAI39378.1; -; mRNA.
DR EMBL; BC145964; AAI45965.1; -; mRNA.
DR CCDS; CCDS22681.1; -.
DR RefSeq; NP_080057.1; NM_025781.2.
DR AlphaFoldDB; Q9D342; -.
DR STRING; 10090.ENSMUSP00000034431; -.
DR GlyGen; Q9D342; 2 sites.
DR PhosphoSitePlus; Q9D342; -.
DR PaxDb; Q9D342; -.
DR PRIDE; Q9D342; -.
DR ProteomicsDB; 263221; -.
DR Antibodypedia; 71565; 4 antibodies from 4 providers.
DR DNASU; 66817; -.
DR Ensembl; ENSMUST00000034431; ENSMUSP00000034431; ENSMUSG00000031953.
DR GeneID; 66817; -.
DR KEGG; mmu:66817; -.
DR UCSC; uc009nmy.1; mouse.
DR CTD; 66817; -.
DR MGI; MGI:106426; Tmem170.
DR VEuPathDB; HostDB:ENSMUSG00000031953; -.
DR eggNOG; KOG4349; Eukaryota.
DR GeneTree; ENSGT00940000159189; -.
DR HOGENOM; CLU_149050_1_1_1; -.
DR InParanoid; Q9D342; -.
DR OMA; AGKTMMS; -.
DR OrthoDB; 1545489at2759; -.
DR PhylomeDB; Q9D342; -.
DR TreeFam; TF314615; -.
DR BioGRID-ORCS; 66817; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tmem170; mouse.
DR PRO; PR:Q9D342; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D342; protein.
DR Bgee; ENSMUSG00000031953; Expressed in metanephric cortical collecting duct and 216 other tissues.
DR Genevisible; Q9D342; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR GO; GO:0006998; P:nuclear envelope organization; ISS:UniProtKB.
DR GO; GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
DR InterPro; IPR019334; Transmembrane_pr_170.
DR PANTHER; PTHR22779; PTHR22779; 1.
DR Pfam; PF10190; Tmemb_170; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..144
FT /note="Transmembrane protein 170A"
FT /id="PRO_0000291760"
FT TOPO_DOM 1..50
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..116
FT /note="Extracellular"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 144 AA; 15224 MW; 4E8BE3927BD7E346 CRC64;
MEREGSGGGG GSAGLLQQIL SLKLVPRVGN GTLCPNSTSL CSFPEMWYGV FLWALMSSVF
FHVPAGLLAL FTLRHHKYGR FMSVSILLMG IVGPITAGIL TSAAIAGVYR AAGKEMIPFE
ALTLGTGQTF CVVVVSFLRV LATL
