T170A_XENLA
ID T170A_XENLA Reviewed; 142 AA.
AC Q6DF87;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Transmembrane protein 170A;
GN Name=tmem170a; Synonyms=tmem170;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate membrane morphogenesis in the endoplasmic
CC reticulum (ER) by promoting ER sheet formation at the expense of ER
CC tubules. {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8WVE7}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8WVE7}.
CC -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
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DR EMBL; BC076855; AAH76855.1; -; mRNA.
DR RefSeq; NP_001086596.1; NM_001093127.1.
DR AlphaFoldDB; Q6DF87; -.
DR DNASU; 446431; -.
DR GeneID; 446431; -.
DR KEGG; xla:446431; -.
DR CTD; 446431; -.
DR Xenbase; XB-GENE-6256227; tmem170a.S.
DR OMA; AGKTMMS; -.
DR OrthoDB; 1545489at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 446431; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR InterPro; IPR019334; Transmembrane_pr_170.
DR PANTHER; PTHR22779; PTHR22779; 1.
DR Pfam; PF10190; Tmemb_170; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Transmembrane protein 170A"
FT /id="PRO_0000291763"
FT TOPO_DOM 1..48
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..114
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 142 AA; 15128 MW; 67363F3DF9BA6DA8 CRC64;
MEGGGGGLGG EPGLLQQILS LRLVPRVGNV TDCQRATLCS FPEMWYGVFL WALVSSLFFH
IPAGLLALFT LRHHKYGRFM SVGIFLMGVL GPISAGILTS AAIAGVYKAA GKEMIPFEAL
VLGVGQTFCV LIVSFLRILA TL