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T170A_XENLA
ID   T170A_XENLA             Reviewed;         142 AA.
AC   Q6DF87;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Transmembrane protein 170A;
GN   Name=tmem170a; Synonyms=tmem170;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate membrane morphogenesis in the endoplasmic
CC       reticulum (ER) by promoting ER sheet formation at the expense of ER
CC       tubules. {ECO:0000250|UniProtKB:Q8WVE7}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8WVE7}; Multi-pass membrane protein
CC       {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q8WVE7}.
CC   -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
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DR   EMBL; BC076855; AAH76855.1; -; mRNA.
DR   RefSeq; NP_001086596.1; NM_001093127.1.
DR   AlphaFoldDB; Q6DF87; -.
DR   DNASU; 446431; -.
DR   GeneID; 446431; -.
DR   KEGG; xla:446431; -.
DR   CTD; 446431; -.
DR   Xenbase; XB-GENE-6256227; tmem170a.S.
DR   OMA; AGKTMMS; -.
DR   OrthoDB; 1545489at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 446431; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0071786; P:endoplasmic reticulum tubular network organization; ISS:UniProtKB.
DR   InterPro; IPR019334; Transmembrane_pr_170.
DR   PANTHER; PTHR22779; PTHR22779; 1.
DR   Pfam; PF10190; Tmemb_170; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..142
FT                   /note="Transmembrane protein 170A"
FT                   /id="PRO_0000291763"
FT   TOPO_DOM        1..48
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..114
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..142
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVE7"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   142 AA;  15128 MW;  67363F3DF9BA6DA8 CRC64;
     MEGGGGGLGG EPGLLQQILS LRLVPRVGNV TDCQRATLCS FPEMWYGVFL WALVSSLFFH
     IPAGLLALFT LRHHKYGRFM SVGIFLMGVL GPISAGILTS AAIAGVYKAA GKEMIPFEAL
     VLGVGQTFCV LIVSFLRILA TL
 
 
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