T170B_HUMAN
ID T170B_HUMAN Reviewed; 132 AA.
AC Q5T4T1;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 170B;
GN Name=TMEM170B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH
RP CTNNB1.
RX PubMed=29367600; DOI=10.1038/s41419-017-0128-y;
RA Li M., Han Y., Zhou H., Li X., Lin C., Zhang E., Chi X., Hu J., Xu H.;
RT "Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene
RT that inhibits the Wnt/beta-catenin pathway.";
RL Cell Death Dis. 9:91-91(2018).
CC -!- FUNCTION: Negatively regulates the canonical Wnt signaling in breast
CC cancer cells. Exerts an inhibitory effect on breast cancer growth by
CC inhibiting CTNNB1 stabilization and nucleus translocation, which
CC reduces the activity of Wnt targets (PubMed:29367600).
CC {ECO:0000269|PubMed:29367600}.
CC -!- SUBUNIT: Interacts with CTNNB1(PubMed:29367600).
CC {ECO:0000269|PubMed:29367600}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29367600};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in normal breast tissues. Down-regulated
CC in breast cancer cells (at protein level) (PubMed:29367600).
CC {ECO:0000269|PubMed:29367600}.
CC -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000305}.
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DR EMBL; AL357518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43425.1; -.
DR RefSeq; NP_001094299.1; NM_001100829.2.
DR AlphaFoldDB; Q5T4T1; -.
DR STRING; 9606.ENSP00000368737; -.
DR GlyGen; Q5T4T1; 1 site.
DR iPTMnet; Q5T4T1; -.
DR PhosphoSitePlus; Q5T4T1; -.
DR BioMuta; TMEM170B; -.
DR DMDM; 74744982; -.
DR PaxDb; Q5T4T1; -.
DR PeptideAtlas; Q5T4T1; -.
DR PRIDE; Q5T4T1; -.
DR Antibodypedia; 71126; 5 antibodies from 5 providers.
DR DNASU; 100113407; -.
DR Ensembl; ENST00000379426.2; ENSP00000368737.1; ENSG00000205269.6.
DR GeneID; 100113407; -.
DR KEGG; hsa:100113407; -.
DR MANE-Select; ENST00000379426.2; ENSP00000368737.1; NM_001100829.3; NP_001094299.1.
DR UCSC; uc010jpa.5; human.
DR CTD; 100113407; -.
DR DisGeNET; 100113407; -.
DR GeneCards; TMEM170B; -.
DR HGNC; HGNC:34244; TMEM170B.
DR HPA; ENSG00000205269; Tissue enhanced (bone).
DR neXtProt; NX_Q5T4T1; -.
DR OpenTargets; ENSG00000205269; -.
DR PharmGKB; PA162405923; -.
DR VEuPathDB; HostDB:ENSG00000205269; -.
DR eggNOG; KOG4349; Eukaryota.
DR GeneTree; ENSGT00940000160424; -.
DR HOGENOM; CLU_149050_0_0_1; -.
DR InParanoid; Q5T4T1; -.
DR OMA; LRQHKYG; -.
DR OrthoDB; 1545489at2759; -.
DR PhylomeDB; Q5T4T1; -.
DR TreeFam; TF314615; -.
DR PathwayCommons; Q5T4T1; -.
DR SignaLink; Q5T4T1; -.
DR BioGRID-ORCS; 100113407; 35 hits in 1070 CRISPR screens.
DR Pharos; Q5T4T1; Tdark.
DR PRO; PR:Q5T4T1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5T4T1; protein.
DR Bgee; ENSG00000205269; Expressed in Brodmann (1909) area 23 and 166 other tissues.
DR Genevisible; Q5T4T1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR019334; Transmembrane_pr_170.
DR PANTHER; PTHR22779; PTHR22779; 1.
DR Pfam; PF10190; Tmemb_170; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Wnt signaling pathway.
FT CHAIN 1..132
FT /note="Transmembrane protein 170B"
FT /id="PRO_0000342267"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 132 AA; 14360 MW; DA9D091B59214A52 CRC64;
MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH GAAGVLMFVM
LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA GKNMAPLEAL VWGVGQTVLT
LIISFSRILA TL
