ID   T170B_MOUSE             Reviewed;         132 AA.
AC   P86050;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Transmembrane protein 170B {ECO:0000312|MGI:MGI:3647046};
GN   Name=Tmem170b {ECO:0000312|MGI:MGI:3647046};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBUNIT: Interacts with CTNNB1. {ECO:0000250|UniProtKB:Q5T4T1}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5T4T1};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM170 family. {ECO:0000255}.
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DR   EMBL; AC133159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS49248.1; -.
DR   RefSeq; NP_001157044.1; NM_001163572.1.
DR   AlphaFoldDB; P86050; -.
DR   STRING; 10090.ENSMUSP00000131144; -.
DR   GlyGen; P86050; 1 site.
DR   PhosphoSitePlus; P86050; -.
DR   PaxDb; P86050; -.
DR   PRIDE; P86050; -.
DR   Antibodypedia; 71126; 5 antibodies from 5 providers.
DR   Ensembl; ENSMUST00000129449; ENSMUSP00000131144; ENSMUSG00000087370.
DR   GeneID; 621976; -.
DR   KEGG; mmu:621976; -.
DR   UCSC; uc011yyr.1; mouse.
DR   CTD; 100113407; -.
DR   MGI; MGI:3647046; Tmem170b.
DR   VEuPathDB; HostDB:ENSMUSG00000087370; -.
DR   eggNOG; KOG4349; Eukaryota.
DR   GeneTree; ENSGT00940000160424; -.
DR   HOGENOM; CLU_149050_0_0_1; -.
DR   InParanoid; P86050; -.
DR   OMA; LRQHKYG; -.
DR   OrthoDB; 1545489at2759; -.
DR   PhylomeDB; P86050; -.
DR   TreeFam; TF314615; -.
DR   BioGRID-ORCS; 621976; 3 hits in 71 CRISPR screens.
DR   PRO; PR:P86050; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; P86050; protein.
DR   Bgee; ENSMUSG00000087370; Expressed in otolith organ and 216 other tissues.
DR   ExpressionAtlas; P86050; baseline and differential.
DR   Genevisible; P86050; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019334; Transmembrane_pr_170.
DR   PANTHER; PTHR22779; PTHR22779; 1.
DR   Pfam; PF10190; Tmemb_170; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..132
FT                   /note="Transmembrane protein 170B"
FT                   /id="PRO_0000354976"
FT   TOPO_DOM        1..37
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..132
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        12
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  14416 MW;  D290011654AE49ED CRC64;
     MRAEGADHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH GAAGVLMFVM
     LQRHRQGRVI SIIAVSIGFL ASVTGAMITS AAVAGIYRVA GKNMAPLEAL VWGVGQTVLT
     LIISFSRILA TL