ID   T176A_BOVIN             Reviewed;         241 AA.
AC   Q7YQI4; A3KMZ5;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Transmembrane protein 176A;
DE   AltName: Full=Corpus luteum protein 1;
GN   Name=TMEM176A; Synonyms=CL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Corpus luteum;
RA   Boensdorff T., Lingaas F., Roenningen K., Farstad W., Olsaker I.;
RT   "Characterization of a novel bovine gene expressed in the corpus luteum.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
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DR   EMBL; AY243098; AAP46091.1; -; mRNA.
DR   EMBL; AY243099; AAP46092.1; -; Genomic_DNA.
DR   EMBL; BC133443; AAI33444.1; -; mRNA.
DR   RefSeq; NP_991348.1; NM_205779.1.
DR   AlphaFoldDB; Q7YQI4; -.
DR   STRING; 9913.ENSBTAP00000016021; -.
DR   PaxDb; Q7YQI4; -.
DR   GeneID; 404082; -.
DR   KEGG; bta:404082; -.
DR   CTD; 55365; -.
DR   eggNOG; ENOG502SF8T; Eukaryota.
DR   HOGENOM; CLU_090530_1_0_1; -.
DR   InParanoid; Q7YQI4; -.
DR   OrthoDB; 1402262at2759; -.
DR   TreeFam; TF335389; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR009281; TMEM176A/TMEM176B.
DR   PANTHER; PTHR15756; PTHR15756; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..241
FT                   /note="Transmembrane protein 176A"
FT                   /id="PRO_0000279871"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         38
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DCS1"
SQ   SEQUENCE   241 AA;  26500 MW;  153B61E8FA0F8BD1 CRC64;
     METVDCGEAA PRAPQPASIQ VHFHHESGLA KLLLGGCSLL QPLLLPRPRA TSRALGRHRL
     LATSWVMQIV LGLLSGVLGG FLYIFSSTTL RNSGAPIWTG AVAVLAGAVA FIYEKRGGIY
     WALLRTLLAL AAFSTATAAT IIGAGRFYEY HFIFYKGICN VSPSWRPTGA PTLSPDLERL
     QQCTAYVNML KALFISINAM LLGVWVLLLL ASLLPLCLCC WRRYRRKEKR DLPLEETVRS
     E