T176A_HUMAN
ID T176A_HUMAN Reviewed; 235 AA.
AC Q96HP8; D3DX00; Q9NYC7;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Transmembrane protein 176A;
DE AltName: Full=Hepatocellular carcinoma-associated antigen 112;
GN Name=TMEM176A; Synonyms=HCA112;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-122 AND ALA-208.
RC TISSUE=Hepatoma;
RX PubMed=12097419; DOI=10.4049/jimmunol.169.2.1102;
RA Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y.,
RA Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W.,
RA Chen W.-F.;
RT "Large scale identification of human hepatocellular carcinoma-associated
RT antigens by autoantibodies.";
RL J. Immunol. 169:1102-1109(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96HP8; P11912: CD79A; NbExp=3; IntAct=EBI-2800645, EBI-7797864;
CC Q96HP8; Q9HA82: CERS4; NbExp=3; IntAct=EBI-2800645, EBI-2622997;
CC Q96HP8; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-2800645, EBI-712073;
CC Q96HP8; O95279: KCNK5; NbExp=3; IntAct=EBI-2800645, EBI-3934936;
CC Q96HP8; Q99732: LITAF; NbExp=3; IntAct=EBI-2800645, EBI-725647;
CC Q96HP8; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-2800645, EBI-373355;
CC Q96HP8; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-2800645, EBI-3923617;
CC Q96HP8; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-2800645, EBI-10192441;
CC Q96HP8; Q9BSN4: SCD5; NbExp=3; IntAct=EBI-2800645, EBI-13385260;
CC Q96HP8; O95470: SGPL1; NbExp=3; IntAct=EBI-2800645, EBI-1046170;
CC Q96HP8; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-2800645, EBI-6268651;
CC Q96HP8; Q3YBM2: TMEM176B; NbExp=3; IntAct=EBI-2800645, EBI-2821479;
CC Q96HP8; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2800645, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
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DR EMBL; AF258340; AAF68667.1; -; mRNA.
DR EMBL; AC006479; AAP21884.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54089.1; -; Genomic_DNA.
DR EMBL; CH471173; EAW54091.1; -; Genomic_DNA.
DR EMBL; BC008303; AAH08303.1; -; mRNA.
DR CCDS; CCDS5909.1; -.
DR RefSeq; NP_060957.2; NM_018487.2.
DR AlphaFoldDB; Q96HP8; -.
DR BioGRID; 120643; 20.
DR IntAct; Q96HP8; 17.
DR STRING; 9606.ENSP00000417626; -.
DR TCDB; 1.A.37.8.2; the cd20 ca(2+) channel (cd20) family.
DR GlyGen; Q96HP8; 1 site, 2 O-linked glycans (1 site).
DR iPTMnet; Q96HP8; -.
DR PhosphoSitePlus; Q96HP8; -.
DR BioMuta; TMEM176A; -.
DR DMDM; 74731960; -.
DR jPOST; Q96HP8; -.
DR MassIVE; Q96HP8; -.
DR PaxDb; Q96HP8; -.
DR PeptideAtlas; Q96HP8; -.
DR PRIDE; Q96HP8; -.
DR ProteomicsDB; 76773; -.
DR Antibodypedia; 2112; 114 antibodies from 23 providers.
DR DNASU; 55365; -.
DR Ensembl; ENST00000004103.8; ENSP00000004103.3; ENSG00000002933.9.
DR Ensembl; ENST00000484928.5; ENSP00000417626.1; ENSG00000002933.9.
DR GeneID; 55365; -.
DR KEGG; hsa:55365; -.
DR MANE-Select; ENST00000004103.8; ENSP00000004103.3; NM_018487.3; NP_060957.2.
DR UCSC; uc003whx.2; human.
DR CTD; 55365; -.
DR DisGeNET; 55365; -.
DR GeneCards; TMEM176A; -.
DR HGNC; HGNC:24930; TMEM176A.
DR HPA; ENSG00000002933; Tissue enhanced (kidney, liver).
DR MIM; 610334; gene.
DR neXtProt; NX_Q96HP8; -.
DR OpenTargets; ENSG00000002933; -.
DR PharmGKB; PA162405947; -.
DR VEuPathDB; HostDB:ENSG00000002933; -.
DR eggNOG; ENOG502SF8T; Eukaryota.
DR GeneTree; ENSGT00530000064074; -.
DR HOGENOM; CLU_090530_1_0_1; -.
DR InParanoid; Q96HP8; -.
DR OMA; TAFIYEK; -.
DR OrthoDB; 1402262at2759; -.
DR PhylomeDB; Q96HP8; -.
DR TreeFam; TF335389; -.
DR PathwayCommons; Q96HP8; -.
DR SignaLink; Q96HP8; -.
DR BioGRID-ORCS; 55365; 8 hits in 1073 CRISPR screens.
DR ChiTaRS; TMEM176A; human.
DR GenomeRNAi; 55365; -.
DR Pharos; Q96HP8; Tbio.
DR PRO; PR:Q96HP8; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96HP8; protein.
DR Bgee; ENSG00000002933; Expressed in right lobe of liver and 174 other tissues.
DR ExpressionAtlas; Q96HP8; baseline and differential.
DR Genevisible; Q96HP8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IBA:GO_Central.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR009281; TMEM176A/TMEM176B.
DR PANTHER; PTHR15756; PTHR15756; 1.
DR Pfam; PF04103; CD20; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..235
FT /note="Transmembrane protein 176A"
FT /id="PRO_0000279872"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9DCS1"
FT VARIANT 122
FT /note="T -> A (in dbSNP:rs741064)"
FT /evidence="ECO:0000269|PubMed:12097419"
FT /id="VAR_031032"
FT VARIANT 187
FT /note="L -> F (in dbSNP:rs10378)"
FT /id="VAR_031033"
FT VARIANT 208
FT /note="T -> A (in dbSNP:rs9088)"
FT /evidence="ECO:0000269|PubMed:12097419"
FT /id="VAR_031034"
SQ SEQUENCE 235 AA; 26116 MW; F44045DC0FEA5C82 CRC64;
MGTADSDEMA PEAPQHTHID VHIHQESALA KLLLTCCSAL RPRATQARGS SRLLVASWVM
QIVLGILSAV LGGFFYIRDY TLLVTSGAAI WTGAVAVLAG AAAFIYEKRG GTYWALLRTL
LTLAAFSTAI AALKLWNEDF RYGYSYYNSA CRISSSSDWN TPAPTQSPEE VRRLHLCTSF
MDMLKALFRT LQAMLLGVWI LLLLASLTPL WLYCWRMFPT KGKRDQKEML EVSGI
