ID   T176A_RAT               Reviewed;         243 AA.
AC   Q4G068;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 176A;
GN   Name=Tmem176a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
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DR   EMBL; BC098714; AAH98714.1; -; mRNA.
DR   RefSeq; NP_001034097.1; NM_001039008.1.
DR   AlphaFoldDB; Q4G068; -.
DR   STRING; 10116.ENSRNOP00000048649; -.
DR   PaxDb; Q4G068; -.
DR   PRIDE; Q4G068; -.
DR   Ensembl; ENSRNOT00000049891; ENSRNOP00000048649; ENSRNOG00000023708.
DR   GeneID; 297077; -.
DR   KEGG; rno:297077; -.
DR   CTD; 55365; -.
DR   RGD; 1310725; Tmem176a.
DR   eggNOG; ENOG502SF8T; Eukaryota.
DR   GeneTree; ENSGT00530000064074; -.
DR   HOGENOM; CLU_090530_1_0_1; -.
DR   InParanoid; Q4G068; -.
DR   OMA; TAFIYEK; -.
DR   OrthoDB; 1402262at2759; -.
DR   PhylomeDB; Q4G068; -.
DR   TreeFam; TF335389; -.
DR   PRO; PR:Q4G068; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000023708; Expressed in liver and 20 other tissues.
DR   Genevisible; Q4G068; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:2001199; P:negative regulation of dendritic cell differentiation; ISO:RGD.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR009281; TMEM176A/TMEM176B.
DR   PANTHER; PTHR15756; PTHR15756; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..243
FT                   /note="Transmembrane protein 176A"
FT                   /id="PRO_0000279874"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         42
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DCS1"
SQ   SEQUENCE   243 AA;  26613 MW;  BF14B3D916764F75 CRC64;
     MSTDMGTADV GEVDPEAPQP TNIEVHIHQE SVLAKLLLAG CSFLRVPASA STQSQGSSRV
     LVASWVVQIV LGILSVVLGG ILYICHYLAM NTQGAPFWTG IVAMLAGAVA FLQKKRGGTC
     WALMRILLVL ASFCTAVAAI VIGSREFNNY WYYLRDDVCK SDTSYRWSTM PSITPVPEEA
     NRIGLCKYYT SMLKTLLISL QAMLLGVWVL LLLASLIPVC VYLWKRFFTK AETEKKLLGA
     AVI