T176B_PONAB
ID T176B_PONAB Reviewed; 270 AA.
AC Q5R8D6;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Transmembrane protein 176B;
GN Name=TMEM176B;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in the process of maturation of dendritic
CC cells. Required for the development of cerebellar granule cells (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
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DR EMBL; CR859817; CAH91974.1; -; mRNA.
DR RefSeq; NP_001127489.1; NM_001134017.1.
DR AlphaFoldDB; Q5R8D6; -.
DR Ensembl; ENSPPYT00000037280; ENSPPYP00000042841; ENSPPYG00000018174.
DR GeneID; 100174564; -.
DR KEGG; pon:100174564; -.
DR CTD; 28959; -.
DR eggNOG; ENOG502SF8T; Eukaryota.
DR GeneTree; ENSGT00530000064074; -.
DR InParanoid; Q5R8D6; -.
DR OrthoDB; 1300114at2759; -.
DR Proteomes; UP000001595; Chromosome 7.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR009281; TMEM176A/TMEM176B.
DR PANTHER; PTHR15756; PTHR15756; 1.
DR Pfam; PF04103; CD20; 1.
PE 2: Evidence at transcript level;
KW Differentiation; Membrane; Nucleus; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..270
FT /note="Transmembrane protein 176B"
FT /id="PRO_0000279877"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 237..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3YBM2"
FT MOD_RES 245
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3YBM2"
FT MOD_RES 254
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q925D4"
FT MOD_RES 258
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3YBM2"
SQ SEQUENCE 270 AA; 29020 MW; 97EF22946F334C89 CRC64;
MTQNTVIVNG VAMDSRPSQP THINVHIHQE SALTQLLKAG GSLKKFLFHP GDTVPSTARI
GYEQLALGVT QILLGVLSCA LGVCLSLGPW TVLRASGCAF WAGSVAIAAG AGAIVHEKYP
GKLAGYVSSL LTLAGFATVM AAVVLCVNSF IWQTEPFLYI DTVCDRSDPV IPTTGYGWMW
RSEEIQRQKE ECRAYMQMLR KLFTAIRALF LAVCVLKVIV SLASLGVGLR NLCGQSSQPL
NEEGSEKRLL GENSVPPSPS REQTSTAIVL