位置:首页 > 蛋白库 > T176B_PONAB
T176B_PONAB
ID   T176B_PONAB             Reviewed;         270 AA.
AC   Q5R8D6;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Transmembrane protein 176B;
GN   Name=TMEM176B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the process of maturation of dendritic
CC       cells. Required for the development of cerebellar granule cells (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR859817; CAH91974.1; -; mRNA.
DR   RefSeq; NP_001127489.1; NM_001134017.1.
DR   AlphaFoldDB; Q5R8D6; -.
DR   Ensembl; ENSPPYT00000037280; ENSPPYP00000042841; ENSPPYG00000018174.
DR   GeneID; 100174564; -.
DR   KEGG; pon:100174564; -.
DR   CTD; 28959; -.
DR   eggNOG; ENOG502SF8T; Eukaryota.
DR   GeneTree; ENSGT00530000064074; -.
DR   InParanoid; Q5R8D6; -.
DR   OrthoDB; 1300114at2759; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR   GO; GO:2001199; P:negative regulation of dendritic cell differentiation; IEA:Ensembl.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR009281; TMEM176A/TMEM176B.
DR   PANTHER; PTHR15756; PTHR15756; 1.
DR   Pfam; PF04103; CD20; 1.
PE   2: Evidence at transcript level;
KW   Differentiation; Membrane; Nucleus; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="Transmembrane protein 176B"
FT                   /id="PRO_0000279877"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          237..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         236
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3YBM2"
FT   MOD_RES         245
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3YBM2"
FT   MOD_RES         254
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q925D4"
FT   MOD_RES         258
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3YBM2"
SQ   SEQUENCE   270 AA;  29020 MW;  97EF22946F334C89 CRC64;
     MTQNTVIVNG VAMDSRPSQP THINVHIHQE SALTQLLKAG GSLKKFLFHP GDTVPSTARI
     GYEQLALGVT QILLGVLSCA LGVCLSLGPW TVLRASGCAF WAGSVAIAAG AGAIVHEKYP
     GKLAGYVSSL LTLAGFATVM AAVVLCVNSF IWQTEPFLYI DTVCDRSDPV IPTTGYGWMW
     RSEEIQRQKE ECRAYMQMLR KLFTAIRALF LAVCVLKVIV SLASLGVGLR NLCGQSSQPL
     NEEGSEKRLL GENSVPPSPS REQTSTAIVL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024