T176B_RAT
ID T176B_RAT Reviewed; 263 AA.
AC Q925D4;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Transmembrane protein 176B;
DE AltName: Full=Protein LR8;
DE AltName: Full=Tolerance-related and induced transcript protein;
GN Name=Tmem176b; Synonyms=Lr8, Torid;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RC STRAIN=Lewis;
RX PubMed=16095493; DOI=10.1111/j.1600-6143.2005.01007.x;
RA Louvet C., Chiffoleau E., Heslan M., Tesson L., Heslan J.-M., Brion R.,
RA Beriou G., Guillonneau C., Khalife J., Anegon I., Cuturi M.-C.;
RT "Identification of a new member of the CD20/FcepsilonRIbeta family
RT overexpressed in tolerated allografts.";
RL Am. J. Transplant. 5:2143-2153(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249 AND SER-253, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Required for the development of cerebellar granule cells (By
CC similarity). May play a role in the process of maturation of dendritic
CC cells. {ECO:0000250, ECO:0000269|PubMed:16095493}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:16095493};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16095493}.
CC -!- TISSUE SPECIFICITY: Expressed in spleen by a variety of myeloid cells
CC including macrophages and dendritic cells (at protein level).
CC Ubiquitously expressed with higher expression in lymphoid tissues.
CC {ECO:0000269|PubMed:16095493}.
CC -!- INDUCTION: Up-regulated in tolerated allografts. Down-regulated in
CC activated macrophages. {ECO:0000269|PubMed:16095493}.
CC -!- MISCELLANEOUS: Overexpression of Tmem176b alters maturation of bone
CC marrow-derived dendritic cells.
CC -!- SIMILARITY: Belongs to the TMEM176 family. {ECO:0000305}.
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DR EMBL; AF370882; AAK51554.1; -; mRNA.
DR EMBL; BC059116; AAH59116.1; -; mRNA.
DR RefSeq; NP_001257518.1; NM_001270589.1.
DR RefSeq; NP_001257519.1; NM_001270590.1.
DR RefSeq; NP_001257520.1; NM_001270591.1.
DR RefSeq; NP_001257521.1; NM_001270592.1.
DR RefSeq; NP_001257522.1; NM_001270593.1.
DR RefSeq; NP_001257523.1; NM_001270594.1.
DR RefSeq; NP_599217.1; NM_134390.3.
DR RefSeq; XP_006236517.1; XM_006236455.3.
DR RefSeq; XP_017447913.1; XM_017592424.1.
DR AlphaFoldDB; Q925D4; -.
DR BioGRID; 251237; 1.
DR IntAct; Q925D4; 3.
DR STRING; 10116.ENSRNOP00000011327; -.
DR iPTMnet; Q925D4; -.
DR PhosphoSitePlus; Q925D4; -.
DR PaxDb; Q925D4; -.
DR PRIDE; Q925D4; -.
DR Ensembl; ENSRNOT00000011327; ENSRNOP00000011327; ENSRNOG00000008465.
DR GeneID; 171411; -.
DR KEGG; rno:171411; -.
DR UCSC; RGD:708403; rat.
DR CTD; 28959; -.
DR RGD; 708403; Tmem176b.
DR eggNOG; ENOG502SF8T; Eukaryota.
DR GeneTree; ENSGT00530000064074; -.
DR InParanoid; Q925D4; -.
DR OMA; WEEDRCR; -.
DR OrthoDB; 1300114at2759; -.
DR PhylomeDB; Q925D4; -.
DR TreeFam; TF335389; -.
DR PRO; PR:Q925D4; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000008465; Expressed in ovary and 20 other tissues.
DR Genevisible; Q925D4; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:2001199; P:negative regulation of dendritic cell differentiation; ISO:RGD.
DR InterPro; IPR007237; CD20-like.
DR InterPro; IPR009281; TMEM176A/TMEM176B.
DR PANTHER; PTHR15756; PTHR15756; 1.
DR Pfam; PF04103; CD20; 1.
PE 1: Evidence at protein level;
KW Differentiation; Membrane; Nucleus; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..263
FT /note="Transmembrane protein 176B"
FT /id="PRO_0000279878"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 242..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 249
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 253
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 263 AA; 28485 MW; 49F231E020A2DE31 CRC64;
MAQATVTVDG VKVTSTRPQS AQISIHIHHK SALEQLLGAM GSLKKFLSYP QARIHYGQLS
LGVTQILLGL VSCVLGVCLY FGPWTELCAS GCAFWSGSVA ILAGVGIVIH EMGQGKLSGH
ISRLLLLACS ATAAAATVMG VKSLIWQTSA SYYFEISSTC DSLQPSIVDR FRSVRFTDDS
DWRTERCREY LRMMMNLFLA FCILFTVICI LKIVVSVASL GLSLRSMCGR NSQVLNDEET
EKKLLGGDSA PASPTKEKIP VTP
