ID   T178A_DANRE             Reviewed;         301 AA.
AC   Q08CE6;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Transmembrane protein 178A;
DE   Flags: Precursor;
GN   Name=tmem178a; Synonyms=tmem178; ORFNames=zgc:153181;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a negative regulator of osteoclast
CC       differentiation. {ECO:0000250|UniProtKB:Q9CZ16}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9CZ16}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR   EMBL; BC124270; AAI24271.1; -; mRNA.
DR   RefSeq; NP_001070108.1; NM_001076640.1.
DR   AlphaFoldDB; Q08CE6; -.
DR   STRING; 7955.ENSDARP00000027372; -.
DR   PaxDb; Q08CE6; -.
DR   GeneID; 767702; -.
DR   KEGG; dre:767702; -.
DR   CTD; 130733; -.
DR   ZFIN; ZDB-GENE-060929-756; tmem178.
DR   eggNOG; ENOG502R2WV; Eukaryota.
DR   InParanoid; Q08CE6; -.
DR   OrthoDB; 1336222at2759; -.
DR   PhylomeDB; Q08CE6; -.
DR   PRO; PR:Q08CE6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039625; T178A/B.
DR   PANTHER; PTHR32005; PTHR32005; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..301
FT                   /note="Transmembrane protein 178A"
FT                   /id="PRO_0000287283"
FT   TOPO_DOM        26..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        237..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..301
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   301 AA;  33992 MW;  C9385CB327C6D3BF CRC64;
     MEKRALVTAI SLSMSLLALM LLVTAIFTDH WYETDTRRHK ENCDQYGSES NDQKNREMPI
     YHLPLVDSGN AKRNLALMKP IHVGSREEEL LENWRAILGM GILETECGRP LFSTYSGLWR
     KCYFQGMDRD IDKLILKGIA ERCTSVKYHF SQPIRLRNIP LNLTRTIQQD EWHLLHLRRI
     TAGFLGMAAA VMLCGSIVAA VGFFWEESLT QHVSGLLFLM AGIFCTISLC TYAASVSYDL
     SRNPPFIYGL PSDVDHGYGW SIFCAWVSLG LTVASGCICT TYPFLSRTKA LRSKTARESS
     V