ID   T178A_RAT               Reviewed;         297 AA.
AC   Q68FV0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Transmembrane protein 178A;
DE   Flags: Precursor;
GN   Name=Tmem178a; Synonyms=Tmem178;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as a negative regulator of osteoclast differentiation in
CC       basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+)
CC       fluxes, thereby controlling the induction of NFATC1.
CC       {ECO:0000250|UniProtKB:Q9CZ16}.
CC   -!- SUBUNIT: Interacts with STIM1. {ECO:0000250|UniProtKB:Q9CZ16}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9CZ16}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM178 family. {ECO:0000305}.
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DR   EMBL; BC079338; AAH79338.1; -; mRNA.
DR   RefSeq; NP_001004282.1; NM_001004282.1.
DR   AlphaFoldDB; Q68FV0; -.
DR   STRING; 10116.ENSRNOP00000010927; -.
DR   GlyGen; Q68FV0; 1 site.
DR   PaxDb; Q68FV0; -.
DR   Ensembl; ENSRNOT00000010927; ENSRNOP00000010927; ENSRNOG00000007907.
DR   GeneID; 362691; -.
DR   KEGG; rno:362691; -.
DR   UCSC; RGD:1303057; rat.
DR   CTD; 130733; -.
DR   RGD; 1303057; Tmem178a.
DR   eggNOG; ENOG502R2WV; Eukaryota.
DR   InParanoid; Q68FV0; -.
DR   OrthoDB; 1336222at2759; -.
DR   PhylomeDB; Q68FV0; -.
DR   TreeFam; TF331307; -.
DR   PRO; PR:Q68FV0; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR039625; T178A/B.
DR   PANTHER; PTHR32005; PTHR32005; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..297
FT                   /note="Transmembrane protein 178A"
FT                   /id="PRO_0000287282"
FT   TOPO_DOM        26..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..208
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..297
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          41..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  33080 MW;  476C75629798E664 CRC64;
     MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA DPPDQKNRLM
     PLSHLPLRDS PPLGRRLLPG GPGRSDPESW RSLLGLGGLD AECGRPLFAT YSGLWRKCYF
     LGIDRDIDTL ILKGIAQRCT AVKYHFSQPI RLRNIPFNLT KIIQQDEWHL LHLRRITAGF
     LGMAVAVLLC GCIVATVSFF WEESLTQHVA GLLFLMTGIF CTISLCTYAA SVSYDLNRVP
     KLIYSLPHDV EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAHLK SGRDSTV